Protein Summary
Isoform 1: May be involved in RNA splicing. Isoform 2: Functions as an apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:15004034). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (PubMed:15509781). Negatively regulates oxidative stress-induced apoptosi ...more
- ENST00000268605
- ENSP00000268605
- ENSG00000140939
- ENST00000564053
- ENSP00000457243
- ENST00000568146
- ENSP00000454598
- ARC
- NOP
- ARC
- FCM
- MYP
- NOP
- NOP30
- MYOCL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
biological process | 0.94 | ||
molecular function | 0.84 | ||
virus perturbation | 0.83 | ||
histone modification site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.01 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 349 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.01 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 349 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0