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Tdark Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]

 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 1.55
PubTator Score 2.03

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count
Alcoholic Intoxication, Chronic 289
Disease Target Count P-value
ependymoma 4679 1.3e-15
Astrocytoma, Pilocytic 3081 1.5e-09
adrenocortical carcinoma 1428 1.7e-06
Breast cancer 3578 1.0e-05
osteosarcoma 7950 3.5e-05
breast carcinoma 1638 8.5e-04
group 3 medulloblastoma 4104 2.3e-02
Disease Target Count Z-score Confidence
Alcohol dependence 107 3.597 1.8

Expression

  Differential Expression (7)

Disease log2 FC p
adrenocortical carcinoma -2.190 1.7e-06
Astrocytoma, Pilocytic -1.600 1.5e-09
Breast cancer 1.300 1.0e-05
breast carcinoma 2.300 8.5e-04
ependymoma -1.500 1.3e-15
group 3 medulloblastoma 1.200 2.3e-02
osteosarcoma 1.414 3.5e-05

Synonym

Accession Q4KMZ8 A2VDJ3 B7Z5F5 B7Z5W9 Q9H9M7 Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Symbols FAM77C

Gene

NKAIN1

  Ortholog (11)

Species Source Disease
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (9)

 GO Function (1)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (9)

 HCA RNA Cell Line (53)

See all...

Protein-protein Interaction (66)

TRPM7   ATP12A   PIGO   SLC12A9   ATP13A2   ADGRL1   SLC4A2   SLC15A4   SNX14   RETSAT   PNPLA6   DNAJC16   GHDC   SLC27A2   SLC29A1   C1orf43   ATP11C   FADS1   PLPPR3   ABCD4   SMPD2   FZD2   GJA1   EPHX1   TAP2   LRRC8D   MACO1   TRPM4   GPR89A   CYB5R1   TMEM219   FZD6   SLC12A4   SLC12A6   CNNM1   SLC27A6   CGRRF1   LRRC8E   LRRC8A   LRRC8C   TMEM63B   ZDHHC9   SLC44A1   COA1   ABCA3   LCLAT1   KCNJ8   ST7   DHRS3   TMEM39B   LPAR3   ADGRE5   FAM189B   PARP16   SLC27A3   ABCC10   PXMP2   MBTPS2   GP1BB   ADCY6   SLC47A1   CLCN7   TMEM63A   TUSC3   ANO6   BTN2A2  

Gene RIF (1)

AA Sequence 

MGKCSGRCTLVAFCCLQLVAALERQIFDFLGYQWAPILANFLHIMAVILGIFGTVQYRSRYLILYAAWLV      1 - 70
LWVGWNAFIICFYLEVGQLSQDRDFIMTFNTSLHRSWWMENGPGCLVTPVLNSRLALEDHHVISVTGCLL     71 - 140
DYPYIEALSSALQIFLALFGFVFACYVSKVFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPLYTSG       141 - 207
//

Text Mined References (6)

PMID Year Title