Tbio | Magnesium transporter NIPA4 |
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6 | 1 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Congenital Nonbullous Ichthyosiform Erythroderma | 16 |
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6694 | 8.5e-31 |
ovarian cancer | 8520 | 1.5e-14 |
osteosarcoma | 7950 | 5.1e-05 |
interstitial cystitis | 2312 | 5.7e-04 |
medulloblastoma, large-cell | 6241 | 6.5e-04 |
urothelial carcinoma | 318 | 4.8e-02 |
Disease | Target Count |
---|---|
Congenital ichthyosiform erythroderma | 28 |
Congenital non-bullous ichthyosiform erythroderma | 7 |
Disease | log2 FC | p |
---|---|---|
interstitial cystitis | -1.900 | 5.7e-04 |
medulloblastoma, large-cell | 1.300 | 6.5e-04 |
osteosarcoma | 1.124 | 5.1e-05 |
ovarian cancer | 1.300 | 1.5e-14 |
psoriasis | 1.100 | 8.5e-31 |
urothelial carcinoma | -1.300 | 4.8e-02 |
Species | Source | Disease |
---|---|---|
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
MPGDSSPGTLPLWDASLSPPLGPDPGGFSRASHAGDKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSNT 1 - 70 SCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKK 71 - 140 KGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSY 141 - 210 FLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPR 211 - 280 YGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDI 281 - 350 FNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHM 351 - 420 HKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS 421 - 466 //