| Tbio | Magnesium transporter NIPA4 |
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 6 | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Congenital Nonbullous Ichthyosiform Erythroderma | 16 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 8.5e-31 |
| ovarian cancer | 8520 | 1.5e-14 |
| osteosarcoma | 7950 | 5.1e-05 |
| interstitial cystitis | 2312 | 5.7e-04 |
| medulloblastoma, large-cell | 6241 | 6.5e-04 |
| urothelial carcinoma | 318 | 4.8e-02 |
| Disease | Target Count |
|---|---|
| Congenital ichthyosiform erythroderma | 28 |
| Congenital non-bullous ichthyosiform erythroderma | 7 |
| Disease | log2 FC | p |
|---|---|---|
| interstitial cystitis | -1.900 | 5.7e-04 |
| medulloblastoma, large-cell | 1.300 | 6.5e-04 |
| osteosarcoma | 1.124 | 5.1e-05 |
| ovarian cancer | 1.300 | 1.5e-14 |
| psoriasis | 1.100 | 8.5e-31 |
| urothelial carcinoma | -1.300 | 4.8e-02 |
MPGDSSPGTLPLWDASLSPPLGPDPGGFSRASHAGDKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSNT 1 - 70 SCENGSLLHLYCSSQEVLCQIVNDLSPEVPSNATFHSWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKK 71 - 140 KGLLRLVATGATRAVDGGFGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSY 141 - 210 FLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPR 211 - 280 YGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDI 281 - 350 FNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASLPHM 351 - 420 HKNPPPSPAPEPTVIRLEDKNVLVDNIELASTSSPEEKPKVFIIHS 421 - 466 //
