Tdark NIPAL1 Magnesium transporter NIPA3

Protein Summary

Description

Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).

Uniprot Accession IDs

• Q6NVV3
• B3KTB0
• Q68DA9

Gene Name

• NIPAL1

Ensembl ID

• ENST00000295461
• ENSP00000295461
• ENSG00000163293

Symbol

• NIPA3
• NPAL1
• NPAL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.9
histone modification site profile	0.87
tissue sample	0.61
cell type or tissue	0.6
virus perturbation	0.59

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc57 Nipa-like Magnesium Transporter Family / Magnesium Transporter Nipa3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0