Tbio NIPA2 Magnesium transporter NIPA2

Protein Summary

Description

Acts as a selective Mg(2+) transporter. This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q8N8Q9
• F8W7Y8
• Q96F03
• Q9BVS2

Gene Name

• NIPA2

Ensembl ID

• ENST00000337451
• ENSP00000337618
• ENSG00000140157
• ENST00000359727
• ENSP00000352762
• ENST00000398013
• ENSP00000381095
• ENST00000398014
• ENSP00000381096
• ENST00000539711
• ENSP00000437746

Symbol

• SLC57A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.84
disease perturbation	0.74
histone modification site profile	0.69
virus perturbation	0.68

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc57 Nipa-like Magnesium Transporter Family / Magnesium Transporter Nipa2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.92   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.92   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0