Tbio NIF3L1 NIF3-like protein 1

Protein Summary

Description

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.

Uniprot Accession IDs

• Q9GZT8
• Q53TX4
• Q6X735
• Q9H2D2
• Q9HC18

Gene Name

• NIF3L1

Ensembl ID

• ENST00000359683
• ENSP00000352711
• ENSG00000196290
• ENST00000409020
• ENSP00000386394
• ENST00000409357
• ENSP00000387315
• ENST00000409588
• ENSP00000387021

Symbol

• ALS2CR1
• CALS-7
• MDS015
• ALS2CR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.88
transcription factor binding site profile	0.84
interacting protein	0.83
kinase perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 274   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0