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Tbio
NFATC4
Nuclear factor of activated T-cells, cytoplasmic 4

Protein Summary
Description
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible express ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250373
  • ENSP00000250373
  • ENSG00000100968
  • ENST00000413692
  • ENSP00000388910
  • ENST00000422617
  • ENSP00000396788
  • ENST00000424781
  • ENSP00000388668
  • ENST00000539237
  • ENSP00000439350
  • ENST00000553469
  • ENSP00000451502
  • ENST00000553708
  • ENSP00000450590
  • ENST00000553879
  • ENSP00000452349
  • ENST00000554050
  • ENSP00000451151
  • ENST00000554344
  • ENSP00000450469
  • ENST00000554473
  • ENSP00000450810
  • ENST00000554591
  • ENSP00000452039
  • ENST00000554661
  • ENSP00000450733
  • ENST00000554966
  • ENSP00000450644
  • ENST00000555167
  • ENSP00000451395
  • ENST00000555393
  • ENSP00000451801
  • ENST00000555453
  • ENSP00000450686
  • ENST00000555590
  • ENSP00000451224
  • ENST00000555802
  • ENSP00000451590
  • ENST00000556169
  • ENSP00000451454
  • ENST00000556279
  • ENSP00000452270
  • ENST00000556759
  • ENSP00000451183
  • ENST00000557451
  • ENSP00000451284
  • ENST00000557767
  • ENSP00000451496
  • ENST00000642182
  • ENSP00000495011
  • ENSG00000285485
  • ENST00000642302
  • ENSP00000494405
  • ENST00000642423
  • ENSP00000495052
  • ENST00000642571
  • ENSP00000493808
  • ENST00000642650
  • ENSP00000495758
  • ENST00000643468
  • ENSP00000494577
  • ENST00000643679
  • ENSP00000493557
  • ENST00000643941
  • ENSP00000493733
  • ENST00000644025
  • ENSP00000494705
  • ENST00000644166
  • ENSP00000496192
  • ENST00000644182
  • ENSP00000495766
  • ENST00000644376
  • ENSP00000493885
  • ENST00000644583
  • ENSP00000496733
  • ENST00000644758
  • ENSP00000495684
  • ENST00000645116
  • ENSP00000493851
  • ENST00000645397
  • ENSP00000493943
  • ENST00000645587
  • ENSP00000495213
  • ENST00000645795
  • ENSP00000495926
  • ENST00000646023
  • ENSP00000494993
  • ENST00000646364
  • ENSP00000496579
  • ENST00000646650
  • ENSP00000496777
  • ENST00000646652
  • ENSP00000496108
  • ENST00000647017
  • ENSP00000496558
  • ENST00000647345
  • ENSP00000493614

Symbol
  • NFAT3
  • NFAT3
  • NF-AT3
  • NF-ATC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
kinase
0.94
molecular function
0.93
transcription factor
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.75   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.75   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0