Tchem NEK7 Serine/threonine-protein kinase Nek7

Protein Summary

Description

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

Uniprot Accession IDs

• Q8TDX7
• A6NGT8

Gene Name

• NEK7

Ensembl ID

• ENST00000367383
• ENSP00000356353
• ENSG00000151414
• ENST00000367385
• ENSP00000356355
• ENST00000538004
• ENSP00000444621

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.93
disease perturbation	0.9
transcription factor binding site profile	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine-protein Kinase Nek7

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nek Family / Serine/threonine-protein Kinase Nek7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.08   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1