Tchem NEK6 Serine/threonine-protein kinase Nek6

Protein Summary

Description

Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361). The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9HC98
• B7Z2D9
• Q5TBG3
• Q5TBG9
• Q6FG86
• Q6IAR3
• Q96E83
• Q9ULX2

Gene Name

• NEK6

Ensembl ID

• ENST00000320246
• ENSP00000319734
• ENSG00000119408
• ENST00000373600
• ENSP00000362702
• ENST00000373603
• ENSP00000362705
• ENST00000394199
• ENSP00000377749
• ENST00000539416
• ENSP00000439651
• ENST00000540326
• ENSP00000441469
• ENST00000545174
• ENSP00000442636
• ENST00000546191
• ENSP00000441426

Symbol

• SID6-1512

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.99
molecular function	0.99
kinase perturbation	0.98
transcription factor	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine-protein Kinase Nek6

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Nek Family / Serine/threonine-protein Kinase Nek6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.6   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.6   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1