NEK4
Serine/threonine-protein kinase Nek4
Protein Summary
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]
- ENST00000233027
- ENSP00000233027
- ENSG00000114904
- ENST00000383721
- ENSP00000373227
- ENST00000535191
- ENSP00000437703
- STK2
- NRK2
- STK2
- pp12301
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
histone modification site profile | 0.9 | ||
protein domain | 0.73 | ||
tissue | 0.7 | ||
tissue sample | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.42 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0