Property Summary

NCBI Gene PubMed Count 20
PubMed Score 33.64
PubTator Score 41.67

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
osteosarcoma -2.386 8.9e-04
glioblastoma 2.100 1.0e-04
sonic hedgehog group medulloblastoma 2.400 1.5e-07
atypical teratoid / rhabdoid tumor 1.900 5.1e-08
medulloblastoma, large-cell 2.300 3.0e-05
primitive neuroectodermal tumor 2.000 8.9e-04
intraductal papillary-mucinous neoplasm ... 1.100 6.5e-03
lung cancer 4.100 7.5e-06
lung adenocarcinoma 1.500 9.4e-08
pediatric high grade glioma 1.800 3.7e-06
Breast cancer 1.800 1.8e-12
invasive ductal carcinoma 1.200 6.5e-03
ovarian cancer 1.400 3.3e-05
psoriasis 1.200 8.1e-46

Gene RIF (11)

PMID Text
25703835 NEIL3 rs12645561 SNP TT genotype was associated with increased risk of myocardial infarction.
24005813 Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM.
23926102 one role for Neil3 and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
23755964 Results show that the base excision and strand incision activities of NEIL3 exhibited a non-concerted action, indicating that NEIL3 mainly operates as a monofunctional DNA glycosylase.
22569481 Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Delta324), as well as the glycosylase domain of human Neil3 (NEIL3Delta324).
22365498 both the transcription and protein levels of hNEIL3 fluctuated during the cell cycle
19170771 NEIL3 partially rescues an E. coli nth nei mutant from hydrogen peroxide sensitivity. Taken together, repair of certain base damage including base loss in ssDNA may be mediated by NEIL3.
18976975 Knockdown of nei endonuclease VIII-like 3 (NEIL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells
18515411 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
12433996 hFPG1 and hFPG2 repair 8-oxoguanine and other DNA oxidation products. (hFPG1 and hFPG2)

AA Sequence

MVEGPGCTLNGEKIRARVLPGQAVTGVRGSALRSLQGRALRLAASTVVVSPQAAALNNDSSQNVLSLFNG      1 - 70
YVYSGVETLGKELFMYFGPKALRIHFGMKGFIMINPLEYKYKNGASPVLEVQLTKDLICFFDSSVELRNS     71 - 140
MESQQRIRMMKELDVCSPEFSFLRAESEVKKQKGRMLGDVLMDQNVLPGVGNIIKNEALFDSGLHPAVKV    141 - 210
CQLTDEQIHHLMKMIRDFSILFYRCRKAGLALSKHYKVYKRPNCGQCHCRITVCRFGDNNRMTYFCPHCQ    211 - 280
KENPQHVDICKLPTRNTIISWTSSRVDHVMDSVARKSEEHWTCVVCTLINKPSSKACDACLTSRPIDSVL    281 - 350
KSEENSTVFSHLMKYPCNTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSP    351 - 420
PASVCLNDIQHPSKKTTNDITQPSSKVNISPTISSESKLFSPAHKKPKTAQYSSPELKSCNPGYSNSELQ    421 - 490
INMTDGPRTLNPDSPRCSKHNRLCILRVVGKDGENKGRQFYACPLPREAQCGFFEWADLSFPFCNHGKRS    491 - 560
TMKTVLKIGPNNGKNFFVCPLGKEKQCNFFQWAENGPGIKIIPGC                             561 - 605
//

Text Mined References (24)

PMID Year Title
25703835 2015 Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study.
24005813 2013 Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population.
23926102 2013 Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.
23755964 2013 Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22569481 2012 Expression and purification of active mouse and human NEIL3 proteins.
22365498 2012 Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway.
19426544 2009 Expression patterns of Neil3 during embryonic brain development and neoplasia.
19170771 2009 Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant.
19121397 2009 Expression and purification of NEIL3, a human DNA glycosylase homolog.
18515411 2008 Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.
18270339 2008 Comprehensive analysis of DNA repair gene variants and risk of meningioma.
17903306 2007 Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study.
16428305 2005 Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15146197 2004 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12713815 2003 The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.
12509226 2002 A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12433996 2002 Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA.
12200441 2002 A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.