Tclin | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mitochondrial complex I deficiency | 46 | 0.0 | 5.0 |
Weight Gain | 100 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Diabetes mellitus type 2 | 69 |
Treatment Refractory Type 2 Diabetes Mellitus | 53 |
Disease | Target Count | P-value |
---|---|---|
Breast cancer | 3578 | 3.2e-04 |
ovarian cancer | 8520 | 6.6e-04 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Osgood-Schlatter's disease | 6 | 3.911 | 2.0 |
Toxoplasmosis | 17 | 3.253 | 1.6 |
Disease | Target Count |
---|---|
Mitochondrial Complex 1 Deficiency | 28 |
Disease | log2 FC | p |
---|---|---|
Breast cancer | 1.100 | 3.2e-04 |
ovarian cancer | 1.800 | 6.6e-04 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG |