| Tclin | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]
This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]
Comments
| Disease | Target Count |
|---|---|
| Diabetes mellitus type 2 | 69 |
| Treatment Refractory Type 2 Diabetes Mellitus | 53 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.9e-05 |
| glioblastoma | 5792 | 7.3e-05 |
| Multiple myeloma | 1332 | 1.1e-02 |
| astrocytic glioma | 2597 | 1.4e-02 |
| Breast cancer | 3578 | 3.3e-02 |
| ependymoma | 4679 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hemochromatosis | 54 | 4.844 | 2.4 |
| Congenital adrenal hyperplasia | 73 | 4.269 | 2.1 |
| Lown-Ganong-Levine syndrome | 3 | 3.772 | 1.9 |
| Immunoglobulin alpha deficiency | 11 | 3.522 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.400 | 1.4e-02 |
| Breast cancer | 2.700 | 3.3e-02 |
| ependymoma | -1.500 | 4.0e-02 |
| glioblastoma | -1.200 | 7.3e-05 |
| Multiple myeloma | 1.039 | 1.1e-02 |
| ovarian cancer | 1.400 | 3.9e-05 |
