Tbio NDNF Protein NDNF

Protein Summary

Description

Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).

Uniprot Accession IDs

• Q8TB73
• A8K0Q0
• Q6UWE5
• Q9H5P7

Gene Name

• NDNF

Ensembl ID

• ENST00000379692
• ENSP00000369014
• ENSG00000173376

Symbol

• C4orf31
• NORD
• C4orf31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.69
histone modification site profile	0.66
biological process	0.63
transcription factor perturbation	0.61
tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.84   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.84   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0