| Tchem | Nuclear receptor corepressor 1 |
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Comments
Property Summary
| Ligand Count | 2 |
| NCBI Gene PubMed Count | 152 |
| PubMed Score | 305.93 |
| PubTator Score | 241.48 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Carcinoma, Transitional Cell | 32 | 0.0 | 0.0 |
| Endometriosis | 540 | 0.0 | 0.0 |
| Hyperbilirubinemia, Neonatal | 5 | 0.0 | 0.0 |
| Liver neoplasms | 130 | 0.0 | 0.0 |
| Urinary Bladder Neoplasms | 114 | 0.0 | 0.0 |
| glioblastoma | 5792 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Bladder Neoplasm | 112 |
| Mammary Neoplasms | 425 |
| Disease | Target Count |
|---|---|
| Peripheral T-cell lymphoma | 25 |
| Primary cutaneous T-cell lymphoma | 29 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.2e-06 |
| malignant mesothelioma | 3232 | 1.6e-06 |
| Pick disease | 1894 | 3.8e-05 |
| osteosarcoma | 7950 | 1.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.0e-04 |
| Breast cancer | 3578 | 3.1e-04 |
| psoriasis | 6694 | 5.0e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.5e-03 |
| oligodendroglioma | 2850 | 5.1e-03 |
| astrocytic glioma | 2597 | 8.1e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 8.2e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.0e-02 |
| ependymoma | 4679 | 1.6e-02 |
| acute myeloid leukemia | 783 | 4.1e-02 |
| pituitary cancer | 1972 | 4.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.100 | 3.1e-04 |
| acute myeloid leukemia | 1.600 | 4.1e-02 |
| astrocytic glioma | 1.600 | 8.1e-03 |
| ependymoma | 1.500 | 1.6e-02 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 2.0e-04 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 1.5e-03 |
| malignant mesothelioma | 1.300 | 1.6e-06 |
| oligodendroglioma | 1.800 | 5.1e-03 |
| osteosarcoma | -1.683 | 1.5e-04 |
| ovarian cancer | -1.500 | 1.2e-06 |
| pancreatic ductal adenocarcinoma liver m... | 1.258 | 8.2e-03 |
| Pick disease | 1.900 | 3.8e-05 |
| pituitary cancer | -1.300 | 4.2e-02 |
| psoriasis | -1.300 | 5.0e-04 |
| subependymal giant cell astrocytoma | -1.086 | 1.0e-02 |
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPS 1 - 70 LLSEFHPGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRAS 71 - 140 ADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLE 141 - 210 EEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIK 211 - 280 TNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIR 281 - 350 KQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINM 351 - 420 NGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKAL 421 - 490 VRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKEKDKIDGTAEE 491 - 560 TEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTE 561 - 630 EEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCE 631 - 700 SVASTVSAQEDEDIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVP 701 - 770 STKPAEDESVETQVNDSISAETAEQMDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDN 771 - 840 TKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGEPERQRMFPMDSKPSLLNP 841 - 910 TGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQ 911 - 980 EQIDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPS 981 - 1050 FIMGGSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPE 1051 - 1120 GLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRM 1121 - 1190 PIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM 1191 - 1260 RESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEG 1261 - 1330 AITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIK 1331 - 1400 HNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQ 1401 - 1470 LSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDP 1471 - 1540 VVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTR 1541 - 1610 QTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITY 1611 - 1680 IPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGS 1681 - 1750 HGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADA 1751 - 1820 LAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSG 1821 - 1890 KPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSS 1891 - 1960 LSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQL 1961 - 2030 PPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNR 2031 - 2100 YSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQ 2101 - 2170 RGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPA 2171 - 2240 VTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRRE 2241 - 2310 EGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGS 2311 - 2380 TQFPYNPLTMRMLSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD 2381 - 2440 //
