| Tchem | Nuclear receptor corepressor 1 |
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Comments
| Disease | Target Count |
|---|---|
| Bladder Neoplasm | 109 |
| Carcinoma, Transitional Cell | 31 |
| Endometriosis | 535 |
| Mammary Neoplasms | 410 |
| glioblastoma | 5572 |
| Disease | Target Count |
|---|---|
| Peripheral T-cell lymphoma | 24 |
| Primary cutaneous T-cell lymphoma | 29 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8492 | 1.19743268486506E-6 |
| malignant mesothelioma | 3163 | 1.60831754537679E-6 |
| Pick disease | 1893 | 3.77671354072124E-5 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 1.96056494576436E-4 |
| Breast cancer | 3099 | 3.12989840496985E-4 |
| psoriasis | 6685 | 6.47646463175906E-4 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00149572128377452 |
| osteosarcoma | 7933 | 0.00197540055036544 |
| oligodendroglioma | 2849 | 0.00506748500275812 |
| astrocytic glioma | 2241 | 0.00810990994352304 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 0.00819589988704515 |
| subependymal giant cell astrocytoma | 2287 | 0.0102599380381391 |
| ependymoma | 2514 | 0.0163194502802677 |
| acute myeloid leukemia | 785 | 0.0412136906670177 |
| pituitary cancer | 1972 | 0.0415012551920076 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | 1.300 | 0.000 |
| astrocytic glioma | 1.600 | 0.008 |
| ependymoma | 1.500 | 0.016 |
| oligodendroglioma | 1.800 | 0.005 |
| psoriasis | -1.500 | 0.001 |
| osteosarcoma | 2.062 | 0.002 |
| pancreatic ductal adenocarcinoma liver m... | 1.258 | 0.008 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 0.001 |
| subependymal giant cell astrocytoma | -1.086 | 0.010 |
| Pick disease | 1.900 | 0.000 |
| acute myeloid leukemia | 1.600 | 0.041 |
| ovarian cancer | -1.500 | 0.000 |
| Breast cancer | -1.100 | 0.000 |
| pituitary cancer | -1.300 | 0.042 |
| Species | Source |
|---|---|
| Macaque | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Horse | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA Inparanoid |
| Chicken | OMA Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| Fruitfly | EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26729869 | NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential. |
| 26663086 | Data suggest that complexes of HDAC3-H1.3 with NCOR1 and NCOR2/SMRT accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 is activated via phosphorylation of Ser-424 by CK2 only in mitosis. |
| 25928846 | The co-localization of AML1-ETO with the N-CoR co-repressor to be primarily on genomic regions distal to transcriptional start sites. (NcoR1) |
| 25823659 | loss of nuclear NCoR results in upregulation of a specific cancer-related genetic signature, and is significantly associated with malignant melanoma progression. |
| 24840043 | Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1) contribute toward transcriptional repression of repeats, presumably increasing genome stability. |
| 24335696 | Low NCoR expression is associated with glioblastoma. |
| 24315104 | Study shows that NCoR1 is a key target of proteolysis and physically interacts with the transcription factor CREB, the genome-wide map described here ties proteolysis in mammalian cells to active enhancers and to promoters of specific gene families. |
| 23940660 | Site directed mutagenic analysis of N-CoR identified serine 1450 as the crucial residue whose phosphorylation by Akt was essential for the misfolding and loss of N-CoR protein. |
| 23428870 | NCOR1 and HDAC3 are instrumental in the repression of glucocorticoid receptor gene transcription. |
| 23295231 | The aberrant cytoplasmic expression of NCoR1 in retinoblastoma appears to be associated with the proliferative and/or dedifferentiated properties of retinoblastoma. |
| More... |
MSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPS 1 - 70 LLSEFHPGSDRPQERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRAS 71 - 140 ADAKKDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLE 141 - 210 EEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIK 211 - 280 TNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIR 281 - 350 KQREQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINM 351 - 420 NGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKAL 421 - 490 VRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKEKDKIDGTAEE 491 - 560 TEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTE 561 - 630 EEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKTSRKPREERDVSQCE 631 - 700 SVASTVSAQEDEDIEASNEEENPEDSEVEAVKPSEDSPENATSRGNTEPAVELEPTTETAPSTSPSLAVP 701 - 770 STKPAEDESVETQVNDSISAETAEQMDVDQQEHSAEEGSVCDPPPATKADSVDVEVRVPENHASKVEGDN 771 - 840 TKERDLDRASEKVEPRDEDLVVAQQINAQRPEPQSDNDSSATCSADEDVDGEPERQRMFPMDSKPSLLNP 841 - 910 TGSILVSSPLKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIGTPVSGYALYQRHIKAMHESALLEEQRQRQ 911 - 980 EQIDLECRSSTSPCGTSKSPNREWEVLQPAPHQVITNLPEGVRLPTTRPTRPPPPLIPSSKTTVASEKPS 981 - 1050 FIMGGSISQGTPGTYLTSHNQASYTQETPKPSVGSISLGLPRQQESAKSATLPYIKQEEFSPRSQNSQPE 1051 - 1120 GLLVRAQHEGVVRGTAGAIQEGSITRGTPTSKISVESIPSLRGSITQGTPALPQTGIPTEALVKGSISRM 1121 - 1190 PIEDSSPEKGREEAASKGHVIYEGKSGHILSYDNIKNAREGTRSPRTAHEISLKRSYESVEGNIKQGMSM 1191 - 1260 RESPVSAPLEGLICRALPRGSPHSDLKERTVLSGSIMQGTPRATTESFEDGLKYPKQIKRESPPIRAFEG 1261 - 1330 AITKGKPYDGITTIKEMGRSIHEIPRQDILTQESRKTPEVVQSTRPIIEGSISQGTPIKFDNNSGQSAIK 1331 - 1400 HNVKSLITGPSKLSRGMPPLEIVPENIKVVERGKYEDVKAGETVRSRHTSVVSSGPSVLRSTLHEAPKAQ 1401 - 1470 LSPGIYDDTSARRTPVSYQNTMSRGSPMMNRTSDVTISSNKSTNHERKSTLTPTQRESIPAKSPVPGVDP 1471 - 1540 VVSHSPFDPHHRGSTAGEVYRSHLPTHLDPAMPFHRALDPAAAAYLFQRQLSPTPGYPSQYQLYAMENTR 1541 - 1610 QTILNDYITSQQMQVNLRPDVARGLSPREQPLGLPYPATRGIIDLTNMPPTILVPHPGGTSTPPMDRITY 1611 - 1680 IPGTQITFPPRPYNSASMSPGHPTHLAAAASAEREREREREKERERERIAAASSDLYLRPGSEQPGRPGS 1681 - 1750 HGYVRSPSPSVRTQETMLQQRPSVFQGTNGTSVITPLDPTAQLRIMPLPAGGPSISQGLPASRYNTAADA 1751 - 1820 LAALVDAAASAPQMDVSKTKESKHEAARLEENLRSRSAAVSEQQQLEQKTLEVEKRSVQCLYTSSAFPSG 1821 - 1890 KPQPHSSVVYSEAGKDKGPPPKSRYEEELRTRGKTTITAANFIDVIITRQIASDKDARERGSQSSDSSSS 1891 - 1960 LSSHRYETPSDAIEVISPASSPAPPQEKLQTYQPEVVKANQAENDPTRQYEGPLHHYRPQQESPSPQQQL 1961 - 2030 PPSSQAEGMGQVPRTHRLITLADHICQIITQDFARNQVSSQTPQQPPTSTFQNSPSALVSTPVRTKTSNR 2031 - 2100 YSPESQAQSVHHQRPGSRVSPENLVDKSRGSRPGKSPERSHVSSEPYEPISPPQVPVVHEKQDSLLLLSQ 2101 - 2170 RGAEPAEQRNDARSPGSISYLPSFFTKLENTSPMVKSKKQEIFRKLNSSGGGDSDMAAAQPGTEIFNLPA 2171 - 2240 VTTSGSVSSRGHSFADPASNLGLEDIIRKALMGSFDDKVEDHGVVMSQPMGVVPGTANTSVVTSGETRRE 2241 - 2310 EGDPSPHSGGVCKPKLISKSNSRKSKSPIPGQGYLGTERPSSVSSVHSEGDYHRQTPGWAWEDRPSSTGS 2311 - 2380 TQFPYNPLTMRMLSSTPPTPIACAPSAVNQAAPHQQNRIWEREPAPLLSAQYETLSDSDD 2381 - 2440 //
| PMID | Year | Title |
|---|---|---|
| 26729869 | 2016 | Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis. |
| 26663086 | 2016 | Mitotic Activation of a Novel Histone Deacetylase 3-Linker Histone H1.3 Protein Complex by Protein Kinase CK2. |
| 26120082 | 2015 | Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. |
| 25928846 | 2015 | Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells. |
| 25823659 | 2015 | Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance. |
| 25772364 | 2015 | SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. |
| 25303530 | 2014 | Enhancer activation requires trans-recruitment of a mega transcription factor complex. |
| 25218447 | 2014 | Uncovering global SUMOylation signaling networks in a site-specific manner. |
| 25114211 | 2014 | Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. |
| 24840043 | 2014 | Holocarboxylase synthetase interacts physically with nuclear receptor co-repressor, histone deacetylase 1 and a novel splicing variant of histone deacetylase 1 to repress repeats. |
| More... |
