Tbio | Putative N-acetyltransferase 8B |
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
osteosarcoma | 7950 | 5.4e-04 |
diabetes mellitus | 1728 | 1.1e-03 |
active ulcerative colitis | 764 | 5.8e-03 |
active Crohn's disease | 922 | 3.1e-02 |
nephrosclerosis | 333 | 4.9e-02 |
Disease | log2 FC | p |
---|---|---|
active Crohn's disease | -1.320 | 3.1e-02 |
active ulcerative colitis | -1.851 | 5.8e-03 |
diabetes mellitus | 1.100 | 1.1e-03 |
nephrosclerosis | -1.281 | 4.9e-02 |
osteosarcoma | -1.156 | 5.4e-04 |