Property Summary

NCBI Gene PubMed Count 13
PubMed Score 76.16
PubTator Score 12.33

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
Multiple myeloma 1.196 4.7e-03
glioblastoma 1.300 9.4e-04
adrenocortical carcinoma 1.257 1.3e-03
intraductal papillary-mucinous carcinoma... 1.300 1.2e-04
intraductal papillary-mucinous neoplasm ... 1.300 1.7e-03
diabetes mellitus -1.100 2.5e-02
ovarian cancer 2.800 1.4e-08
pituitary cancer -1.800 1.0e-07

Protein-protein Interaction (2)

Gene RIF (3)

PMID Text
20800603 Observational study of gene-disease association. (HuGE Navigator)
16597820 The structure of the C-terminal antifreeze-like domain of human sialic acid synthase was determined. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins.
16274664 sialic acid synthases kinetics and preliminary mutagenesis experiments reveal the importance of C-terminal antifreeze protein domain

AA Sequence

MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERP      1 - 70
YTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNF     71 - 140
PYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDVNLRVISEYQKLFPDI    141 - 210
PIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQL    211 - 280
LPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELV    281 - 350
DNHGKKIKS                                                                 351 - 359
//

Text Mined References (17)

PMID Year Title
27213289 2016 NANS-mediated synthesis of sialic acid is required for brain and skeletal development.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
21269460 2011 Initial characterization of the human central proteome.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
16597820 2006 Solution structure of the antifreeze-like domain of human sialic acid synthase.
16274664 2005 Cloning, expression, and characterization of sialic acid synthases.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15164053 2004 DNA sequence and analysis of human chromosome 9.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10873658 2000 Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
10749855 2000 Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.
693772 1978 Event-related slow brain potentials, cognitive processes, and alexithymia.