| Tbio | Nucleus accumbens-associated protein 2 |
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.8e-11 |
| group 3 medulloblastoma | 4104 | 1.6e-08 |
| psoriasis | 6694 | 1.0e-07 |
| acute quadriplegic myopathy | 1158 | 4.0e-07 |
| tuberculosis | 2010 | 5.0e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-05 |
| medulloblastoma, large-cell | 6241 | 1.6e-05 |
| ovarian cancer | 8520 | 1.1e-04 |
| dermatomyositis | 966 | 2.0e-04 |
| osteosarcoma | 7950 | 9.5e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.7e-03 |
| invasive ductal carcinoma | 2951 | 6.9e-03 |
| astrocytoma | 1146 | 1.2e-02 |
| non primary Sjogren syndrome sicca | 891 | 1.4e-02 |
| gastric carcinoma | 807 | 2.8e-02 |
| primitive neuroectodermal tumor | 3035 | 3.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| fiedler's myocarditis | 5 | 4.947 | 2.5 |
| Atrioventricular block | 35 | 4.179 | 2.1 |
| Sick sinus syndrome | 15 | 4.171 | 2.1 |
| Right bundle branch block | 17 | 3.518 | 1.8 |
| Mediastinitis | 7 | 3.344 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.233 | 4.0e-07 |
| astrocytoma | 2.000 | 1.2e-02 |
| Astrocytoma, Pilocytic | 1.100 | 1.3e-05 |
| atypical teratoid / rhabdoid tumor | -1.100 | 4.7e-03 |
| dermatomyositis | 1.700 | 2.0e-04 |
| gastric carcinoma | 1.100 | 2.8e-02 |
| group 3 medulloblastoma | -3.500 | 1.6e-08 |
| invasive ductal carcinoma | -1.700 | 6.9e-03 |
| medulloblastoma, large-cell | -4.900 | 1.6e-05 |
| non primary Sjogren syndrome sicca | 1.400 | 1.4e-02 |
| non-small cell lung cancer | -1.093 | 1.8e-11 |
| osteosarcoma | -1.904 | 9.5e-04 |
| ovarian cancer | -2.100 | 1.1e-04 |
| primitive neuroectodermal tumor | -1.300 | 3.6e-02 |
| psoriasis | -1.300 | 1.0e-07 |
| tuberculosis | 2.300 | 5.0e-06 |
MSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELP 1 - 70 GSVPPACFQQILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGS 71 - 140 EPQSPCNQLQPAAAAAAPYVVSPSVPIPLLTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVA 141 - 210 AGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVE 211 - 280 EQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELVA 281 - 350 GSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRNTLANSCGTGIRSSTSDPSRKPLDSRVLNAVKLY 351 - 420 CQNFAPSFKESEMNVIAADMCTNARRVRKRWLPKIKSMLPEGVEMYRTVMGSAAASVPLDPEFPPAAAQV 421 - 490 FEQRIYAERRGDAATIVALRTDAVNVDLSAAANPAFDAGEEVDGAGSVIQEVAAPEPLPADGQSPPQPFE 491 - 560 QGGGGPSRPQTPAAAARRPEGTYAGTL 561 - 587 //
