Tbio NAA35 N-alpha-acetyltransferase 35, NatC auxiliary subunit

Protein Summary

Description

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.

Uniprot Accession IDs

• Q5VZE5
• Q5VZE6
• Q9H631
• Q9H703

Gene Name

• NAA35

Ensembl ID

• ENST00000361671
• ENSP00000354972
• ENSG00000135040
• ENST00000376040
• ENSP00000365208

Symbol

• EGAP
• MAK10
• EGAP
• MAK10
• MAK10P
• bA379P1.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
transcription factor perturbation	0.94
disease perturbation	0.9
kinase perturbation	0.66
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 35, Natc Auxiliary Subunit

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 35, Natc Auxiliary Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.67   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.67   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0