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Tbio
MYH2
Myosin-2

Protein Summary
Description
Muscle contraction. Required for cytoskeleton organization (By similarity). Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245503
  • ENSP00000245503
  • ENSG00000125414
  • ENST00000397183
  • ENSP00000380367
  • ENST00000532183
  • ENSP00000433944
  • ENST00000622564
  • ENSP00000482463

Symbol
  • MYHSA2
  • IBM3
  • MYH2A
  • MYPOP
  • MYHSA2
  • MYHas8
  • MyHC-2A
  • MyHC-IIa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
gene perturbation
0.95
co-expressed gene
0.89
protein domain
0.85
cellular component
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.11   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.11   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0