Property Summary

NCBI Gene PubMed Count 19
PubMed Score 12.62
PubTator Score 12.95

Knowledge Summary


No data available


  Disease (2)

Disease Target Count
Adenoid Cystic Carcinoma 99
Disease Target Count P-value
posterior fossa group B ependymoma 1530 1.1e-07


  Differential Expression (1)

Disease log2 FC p
posterior fossa group B ependymoma 1.300 1.1e-07

Gene RIF (9)

22050566 c-Myc expression is reduced in pterygium compared with normal conjunctiva.
20562918 miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities.
20544396 Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17595061 An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration.
16866877 AMY-1 coordinates ADP-Ribosylation Factors-mediated membrane trafficking and signaling pathways.
12414807 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits enzyme acdtivity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex
12223483 identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm
11483602 AMY-1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggest that AMY-1 plays a role in spermatogenesis

AA Sequence

EMKEKYEAIVEENKKLKAKLAQYEPPQEEKRAE                                          71 - 103

Text Mined References (22)

PMID Year Title
22050566 2011 Downregulation of c-Myc in pterygium and cultured pterygial cells.
20562918 2010 Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein.
20544396 2010 PinX1 inhibits telomerase activity in gastric cancer cells through Mad1/c-Myc pathway.
20500816 2010 Genomic profiling of tumor initiating prostatospheres.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19054851 2008 Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17595061 2007 c-myc promoter binding protein regulates the cellular response to an altered glucose concentration.
16866877 2006 AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15979100 2005 Identification of MYCBP as a beta-catenin/LEF-1 target using DNA microarray analysis.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12665801 2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12522145 2003 Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12414807 2002 AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex.
12223483 2002 AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase.
12151104 2002 AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis.
11483602 2001 AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase.
9797456 1998 AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.