Tbio | Multivesicular body subunit 12A |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Comments
Disease | Target Count | P-value |
---|---|---|
astrocytoma | 1146 | 4.3e-25 |
ependymoma | 4679 | 4.2e-14 |
Astrocytoma, Pilocytic | 3081 | 2.7e-09 |
glioblastoma | 5792 | 2.5e-08 |
atypical teratoid / rhabdoid tumor | 5112 | 3.0e-07 |
tuberculosis | 2010 | 1.4e-06 |
primitive neuroectodermal tumor | 3035 | 6.2e-05 |
adult high grade glioma | 3801 | 8.7e-05 |
ovarian cancer | 8520 | 3.0e-04 |
group 3 medulloblastoma | 4104 | 4.1e-04 |
oligodendroglioma | 2850 | 1.4e-02 |
subependymal giant cell astrocytoma | 2287 | 1.6e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Autosomal recessive Robinow syndrome | 27 | 3.195 | 1.6 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | 1.400 | 8.7e-05 |
astrocytoma | 1.300 | 4.3e-25 |
Astrocytoma, Pilocytic | 1.500 | 2.7e-09 |
atypical teratoid / rhabdoid tumor | 1.500 | 3.0e-07 |
ependymoma | 1.600 | 4.2e-14 |
glioblastoma | 1.800 | 2.5e-08 |
group 3 medulloblastoma | 1.100 | 4.1e-04 |
oligodendroglioma | 1.300 | 1.4e-02 |
ovarian cancer | 1.700 | 3.0e-04 |
primitive neuroectodermal tumor | 1.300 | 6.2e-05 |
subependymal giant cell astrocytoma | 1.258 | 1.6e-02 |
tuberculosis | 1.200 | 1.4e-06 |
MDPVPGTDSAPLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKSFAQKSGYFLCLSSLGSLENPQENVV 1 - 70 ADIQIVVDKSPLPLGFSPVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVPGYLRIGDM 71 - 140 GGFAIWCKKAKAPRPVPKPRGLSRDMQGLSLDAASQPSKGGLLERTASRLGSRASTLRRNDSIYEASSLY 141 - 210 GISAMDGVPFTLHPRFEGKSCSPLAFSAFGDLTIKSLADIEEEYNYGFVVEKTAAARLPPSVS 211 - 273 //