Tbio MUC17 Mucin-17

Protein Summary

Description

Probably plays a role in maintaining homeostasis on mucosal surfaces. The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q685J3
• O14761
• Q685J2
• Q8TDH7
• MUC-17

Gene Name

• MUC17

Ensembl ID

• ENST00000306151
• ENSP00000302716
• ENSG00000169876

Symbol

• MUC3
• MUC3
• MUC-3
• MUC-17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.63
cell line	0.56
cellular component	0.55
cell type or tissue	0.44
biological term	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.1   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.1   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0