Tbio MTSS1L MTSS1-like protein

Protein Summary

Description

Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation (PubMed:14752106). May function in actin bundling (PubMed:14752106).

Uniprot Accession IDs

• Q765P7
• A6NJI7
• Q9BUA8

Gene Name

• MTSS1L

Ensembl ID

• ENST00000338779
• ENSP00000341171
• ENSG00000132613

Symbol

• ABBA
• ABBA1
• ABBA-1
• MTSS1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.8
microRNA	0.74
tissue sample	0.7
cell line	0.67
small molecule perturbation	0.67

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Mtss1-like Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Mtss1-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.76   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0