| Tclin | Melatonin receptor type 1B |
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 646 |
| NCBI Gene PubMed Count | 139 |
| PubMed Score | 100.57 |
| PubTator Score | 153.09 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autism spectrum disorder | 101 | 0.0 | 0.0 |
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Autism Spectrum Disorders | 75 |
| Diabetes Mellitus, Non-Insulin-Dependent | 145 |
| Schizophrenia | 1160 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 3.0 |
| Cardiovascular system disease | 246 | 0.0 | 3.0 |
| Disease of mental health | 36 | 0.0 | 1.0 |
| Metabolic syndrome X | 52 | 0.0 | 3.0 |
| Type 2 diabetes mellitus | 272 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Gestational diabetes | 26 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Idiopathic scoliosis | 31 | 4.953 | 2.5 |
| diabetes mellitus | 1728 | 4.652 | 2.3 |
| Disease | Target Count |
|---|---|
| Diabetes Mellitus, Noninsulin-Dependent | 31 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG |
tasimelteon
pKi 9.80
ramelteon
pKi 10.39
agomelatine
pKi 10.00
melatonin
pEC50 9.70
ramelteon
- 10.00
tasimelteon
pKi 10.20
CHEMBL366115
pIC50 7.00
CHEMBL359561
pKi 7.01
CHEMBL456646
pIC50 7.01
CHEMBL241928
pKi 7.02
CHEMBL3109562
pKi 7.02
CHEMBL183846
pKi 7.02
CHEMBL19503
pIC50 7.03
CHEMBL1813322
pKi 7.03
CHEMBL3260987
pKi 7.04
CHEMBL364835
pKi 7.05
CHEMBL126005
pKi 7.05
CHEMBL361854
pKi 7.05
CHEMBL181457
pKi 7.05
CHEMBL362097
pKi 7.05
CHEMBL209711
pKi 7.05
CHEMBL19442
pIC50 7.05
CHEMBL3260986
pKi 7.06
CHEMBL123973
pKi 7.06
CHEMBL365249
pKi 7.07
CHEMBL1095522
pKi 7.07
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRK 1 - 70 LRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYC 71 - 140 YICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFL 141 - 210 LPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQE 211 - 280 MAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAP 281 - 350 PIIGVQHQADAL 351 - 362 //
