Property Summary

NCBI Gene PubMed Count 3,120
PubMed Score 4846.77
PubTator Score 5901.32

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (7)

Disease Target Count
Hyperhomocysteinemia 34
Cleft Lip 91
Male infertility 170
Rheumatoid Arthritis 1170
Acute kidney injury 65
Adverse reaction to drug 54
Alopecia 55
Alzheimer's disease 644
Anemia 252
Arsenic Poisoning 59
Atrial Fibrillation 110
Autistic Disorder 320
Bipolar Disorder 266
Bladder Neoplasm 109
Blood Coagulation Disorders, Inherited 1
Blood pressure finding 56
Brain Ischemia 87
Cardiovascular Diseases 50
Cerebrovascular accident 44
Cervical Intraepithelial Neoplasia 2
Colonic Neoplasms 126
Colorectal Neoplasms 217
Congenital Heart Defects 37
Congenital clubfoot 4
Coronary Restenosis 8
Coronary heart disease 59
Depressive disorder 48
Dermatologic disorders 65
Diabetic Angiopathies 7
Drug Eruptions 18
Drug-Induced Liver Injury 118
Endometrial Neoplasms 50
Female infertility 28
Gastrointestinal Diseases 12
Gastrointestinal Stromal Tumors 8
Graft-vs-Host Disease 5
HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY 1
Hearing Loss, Sudden 1
Hematological Disease 8
Hypersensitivity 63
Inflammatory disease of mucous membrane 8
Kidney Diseases 86
Leukoencephalopathies 7
Leukopenia 42
Liver diseases 66
Lung Neoplasms 171
Lymphoma 57
Lymphoma, Follicular 20
Lymphoma, Non-Hodgkin 22
Malnutrition 3
Mammary Neoplasms 410
Maxillofacial Abnormalities 1
Meningomyelocele 4
Methylenetetrahydrofolate reductase deficiency 1
Microsatellite Instability 12
Mthfr Deficiency, Thermolabile Type 1
Necrosis 51
Neoplasm Metastasis 138
Neural Tube Defects 31
Neural tube defect, folate-sensitive 4
Neutropenia 78
OROFACIAL CLEFT 1 2
Peripheral Neuropathy 303
Precursor Cell Lymphoblastic Leukemia Lymphoma 42
Prostatic Neoplasms 471
Sinus Thrombosis, Intracranial 2
Spinal Cord Diseases 3
Stomach Neoplasms 282
Systemic arterial pressure 56
Thrombocytopenia 105
Thyrotoxicosis 38
Uterine Cervical Neoplasm 21
Vascular Diseases 16
Venous Thrombosis 21
chronic lymphocytic leukemia 244
nervous system disorder 53
Disease Target Count Z-score Confidence
Homocystinuria 23 5.887 2.9
spina bifida 1064 4.842 2.4

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma 2.233 4.2e-06
non-small cell lung cancer -1.037 1.3e-11
intraductal papillary-mucinous adenoma (... 1.200 2.6e-02
ovarian cancer -1.100 2.8e-06

 GO Component (2)

Protein-protein Interaction (1)

Gene RIF (3877)

PMID Text
27089387 MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms are associated with Geographical and Ethnic differences.
27068821 Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
27062459 In this study population, no evidence of main or joint effects of polymorphisms and DNA methylation in the MTHFR gene on affecting colorectal adenoma risk was observed.
27017713 we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs
26990189 MTHFR C677T is a potential risk factor for CHD in our local residents of Shandong province in China. HRM is a fast, sensitive, specific and reliable method for clinical application of genotyping
26983014 MTHFR 677 C>T polymorphism does not affect PCOS risk in India. The association seen in the meta-analysis is due to an outlier study and studies showing deviation from the Hardy Weinberg equilibrium
26928923 Mutations in the MTHFR gene were not found to be significantly more frequent in JIA patients intolerant to MTX.
26926955 MTHFR epimutations are likely to contribute to the increased genomic instability observed in cells from mothers of Down syndrome individuals.
26926881 The MTHFR 677 T allele codes a thermolabile and less active enzyme, which is associated with decreased folate and increased homocysteine levels.
26857559 The combination of MTHFR, DRD3 and MDR1 polymorphisms associated with a slow ATV metabolizer phenotype
26854451 Asian populations but not in Caucasian populations, which suggested ethnicity differences between MTHFR A1298C polymorphisms and risk of chronic myelogenous leukemia
26843177 Patients with rheumatoid arthritis, in particular those with ischemic heart disease, show a decreased expression of the MTHFR gene.
26839351 MTHFR C677T is associated with MRI scan-confirmed lacunar stroke, but not large artery or cardioembolic stroke.
26833750 MTHFR G1793A single nucleotide polymorphism showed association with dietary folate intake and gastric cancer in Korea.
26828698 MTHFR C667T loci polymorphism may affect atherosclerosis by regulating genome methylation level.
26813460 MTHFR C677T polymorphism is associated with rheumatic heart disease in patients with mitral valve lesions, perhaps via an homocysteine-mediated cytokine effect.
26806866 the T allele of rs1801133 variant and A-T haplotype of rs1801131-rs1801133 in the MTHFR gene may decrease the risk of developing PD in Chinese Han population from mainland China.
26782572 The association between the MTHFR A1298C CC genotype and prostate cancer risk may vary within different populations. (Meta-analysis)
26780389 The risks of neural tube defects in infants are discussed; the level of erythrocyte folate, folic acid intake, and MTHFR genotype are considered.
26745044 No significant association was found between the MTHFR C677T polymorphism and colorectal cancer.
26728177 Data show that methylenetetrahydrofolate reductase (MTHFR) rs1801133 polymorphism did not affect academic achievement.
26717388 C677T polymorphism as risk factor of early renal damage in hypertension in Chinese Han population
26710543 The data presented in this study support the relationship between MTHFR 677C>T polymorphism and risk in mothers with antecedent of NTD (Neural tube defects) offspring.
26689687 Single nucleotide polymorphisms in MTHFR gene individually and jointly influence susceptibility to age-related cataract by affecting MTHFR enzyme activity and homocysteine levels in Chinese Han Population.
26678951 The rs1801133 polymorphism could be capable of increasing ischemic stroke susceptibility in Asian, male and young-middle populations.
26677583 Women carriers of the mutated variants of both, 677C>T and 1298A>C polymorphisms of the MTHFR gene should receive special perinatal care in order to prevent fetal defects and thrombosis-related complications during pregnancy
26662439 the results of our study indicated that the MTHFR C677T gene polymorphism could play a role in the development of breast cancer.
26662389 Our results suggest that the MTHFR A1298C polymorphism might be related to increased risk of HCC in Asians.
26654251 Findings indicate that the homozygous mutant for 677TT of methylenetetrahydrofolate reductase (MTHFR) gene is associated with the risk of hypertension in Morocco.
26620113 Our study substantiates the involvement of the monoamine oxidase A and 5,10-methylenetetrahydrofolate reductase polymorphisms in climacteric depression.
26596059 The MTHFR C677T genotype is associated with increased risk of Diabetic angiopathy of lower extremities in smoking men.
26564107 Both parameters indicate a better tumor prognosis when the MTHFR 677T variant is present
26561410 Folate status was lower in the MTHFR 677TT and SLC19A1 80AA genotypes compared with corresponding reference genotypes. Low folate status risk associated with the MTHFR 677TT genotype varied depending on its combination with other polymorphisms.
26549413 Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population
26548935 Esophageal cancer risk was significantly increased in people with TT/CT genotype of MTHFR gene.
26540672 In Asian populations, a decreased risk of NSCL/P was observed in patients presenting the C677T variant at MTHFR gene.
26537580 This article suggests that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism was significantly associated with breast cancer risk in Chinese population.
26535623 we propose that MTHFR C677T may represent a putative biomarker for radiotherapy prognosis in la-ryngeal SCC patients.
26522268 The MTHFR mutation c.677C>T was present in 17.3% of 400 ischemic stroke patients in Sri Lanka. It is the predominant mutation and the only mutation that had patients with the homozygous mutant genotype.
26522108 meta-analysis is consistent with MTHFR C677T and MTHFR A1298C polymorphisms not being significantly associated with an increased risk of endometrial cancer
26505368 results indicated that the MTHFR 3'-UTR rs55763075 polymorphism might modify the susceptibility to male infertility with idiopathic azoospermia
26485042 No association was observed between average DNA methylation of MTHFR and colorectal adenoma risk.
26456456 MTHFR C677T might be correlated with the tumor response to preoperative chemoradiotherapy
26439908 there is no association of MTHFR C677T polymorphism with preterm delivery or placental abruption (Meta-Analysis)
26421712 The presence of variant alleles regarding the MTHFR C677T polymorphism interfered with vitamin B6 and ox-LDL cholesterol concentrations
26401555 Cohort study observed prevalence (92.5%) of MTHFR gene mutations in elderly Alzheimer's Disease patients
26399758 Identification of MTHFR C677T mutation would have some implication for primary prevention of RPL[Recurrent pregnancy loss] and screening of high-risk individuals in China.
26380869 significant association of MTHFR-Ala222Val with risk of male infertility, especially in Asian populations
26345936 polymorphisms in MTHFR affect the susceptibility to gastric tumors in the Brazilian population and may be a factor causing poor prognosis in such patients.
26345779 We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes.
26345746 this meta-analysis suggests that the A1298C polymorphism in the MTHFR gene may be not associated with susceptibility to ovarian cancer.
26337056 Low folate status and homocysteine metabolism gene polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) may have a synergistic effect towards increasing the incidence of dyslipidemia in Chinese hypertensive population.
26323926 Chinese Han people with TT/CT genotype of MTHFR gene may have increased risk of developing breast cancer (meta-analysis).
26315791 The C677 T polymorphism of the MTHFR did not associate with acquired-risk factors so it can be suppose that it is an independent risk factor.
26314492 C677T polymorphism in the MTHFR gene is involved in MTX monotherapy discontinuation in a multicentre European patient cohort.
26307085 The most marked loss of DNA methylation was found in sperm from patients homozygous for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism
26282718 Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels
26266420 interactions among homocysteine metabolism gene polymorphisms in MTHFR, MTR and MTRR lead to dramatic elevations in the folate deficiency risk
26261642 Gene type TT of MTHFR C677T polymorphism might make premature delivery risk rise while gene type CC of A1298C polymorphism might have protective influence on premature delivery.
26261166 GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively).
26259392 Suggest alleles specific variation of MTHFR C677T and A1298C associated "risk factor" for the development of ovarian cancer.
26238013 MTHFR C677T mutation was the most common cause of primary Budd-Chiari syndrome.
26231982 The MTHFR c.677C>T polymorphism is associated with reduced BMD in lumbar spine.
26217949 Methylenetetrahydrofolate reductase gene polymorphisms play a role Turner Syndrome in Egyptian patients
26214484 Patients with pre-eclampsia have hypermethylation in the MTHFR gene promoter, which may be one of its causes.
26196053 c.1298A > C polymorphism associated with an increased risk of non-obstructive azoospermia
26191297 APOE, VHL and MTHFR gene polymorphisms were related to the risk of renal cell carcinoma
26187788 The present study suggests that the genotypes and haplotypes of MTHFR 677C>T are potential serum biomarkers in the pathophysiological processes of ischemic stroke.
26177556 results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
26163632 Genetic polymorphism of MTHFR C677T may modulate the risk of breast cancer especially in the 41-60 year age group.
26161693 the MTHFR C677T T allele or TT genotype might be a significant genetic molecular marker to determine the risk of diabetic nephropathy in patients with type 2 diabetes (meta-analysis)
26156333 MTHFR A1298C polymorphism is associated with increased cervical cancer and lymphoma risk in Asians.
26154858 polymorphisms of the MTHFR, MTRR, and MTR enzymes are well documented as folate deficiency-related disorders. The aim of this study was to compare the genotypic distribution of these gene polymorphisms between patients with acromegaly and controls.
26150166 Meta-analysis evaluating the associations between multiple sclerosis and polymorphisms of MTHFR, GSTM1, GSTT1, and GSTP1
26142939 Individuals with the variant MTHFR (C677T) genotypes seem to have greater predisposition to homocysteine concentration increase during Anti-Epileptic Drug treatment.
26137654 Individuals with B12 deficiency with TT MTHFR genotype have higher frequency of hyperhomocysteinemia and vascular dysfunction.
26137554 Both polymorphisms of MTHFR may be involved in the morphological specification of primary varicose veins and contribute to the development of complicated disease.
26135458 The present data showed that FVL, MTHFR polymorphisms also combined with thrombophilic gene mutations have a strong association with recurrent pregnancy loss.
26118060 The C677T MTHFR gene polymorphism is significantly associated with unipolar depression.
26115054 Data (including data from case-control, genetic association studies) suggest that MTHFR mutation C677T is not associated with genetic predisposition for venous thromboembolism or thrombophilia in pregnancy. [META-ANALYSIS, REVIEW]
26111049 MTHFR C677T and A1298C are associated with prognosis in CRC patients undergoing 5-FU-based chemotherapy.
26107198 MTHFR C677T polymorphism does not contribute to the risk of prostate cancer.
26095803 Data suggest that the higher frequency of the methylenetetrahydrofolate reductase (MTHFR) 677 variant allele in South African Indians may be a contributing factor to the higher risk profile for the development of premature coronary artery disease (CAD).
26090795 Variation in MTHFR, MTR, and MTRR were significantly associated with percent LINE-1 methylation.DNA methylation of LINE-1 elements in histologically normal breast tissues is influenced by polymorphisms in genes in the one-carbon metabolism pathway
26083986 The methylenetetrahydrofolate reductase 677TT genotype is not linked with cerebral venous thrombosis, but is a determinant of elevated plasma homocysteine levels.
26081619 this meta-analysis suggests that MTHFR C677T polymorphism is breast cancer, gastric cancer, and hepatocellular cancer risk in Asians
26072975 Review/Meta-analysis: MTHFR C677T variants may influence diabetic nephropathy risk in Chinese population.
26063524 MTHFR genetic polymorphisms are risk factor for predicting cardiovascular manifestations in Marfan syndrome.
26060483 MTHFR gene mutations were associated with a 0.573 (95% CI: 0.228-1.441) fold risk of having >/=3 abortions when compared to having 2 abortions
26046315 MTHFR polymorphisms are associated with colorectal cancer susceptibility.
26037361 MTHFR gene C677T polymorphism is associated with polycystic ovary syndrome.
26037359 The MTHFR 677T and MTRR 66G represent a risk factor for Down syndrome while MTHFR 677T represents a risk factor for Edwards syndrome gestation for Chinese Han females.
26036716 The frequency of the TT mutant genotype of the C677T polymorphism of MTHFR is higher in the placenta of pregnancies complicated with preeclampsia.
26035704 the results of the present study suggest that Homozygous TT alleles of MTHFR C677T polymorphism might be a risk factor for HNC among individuals who have a heavy drinking history.
26031974 Studied MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease; determined increased Hcy levels and increased prevalence of homozygote MTHFR 677C/T and MTHFR 1298A/C mutations in patients with NAFLD compared with healthy controls.
26022785 This meta-analysis suggested that MTHFR polymorphisms were not associated with multiple myeloma risk.
26022245 Data suggest that single nucleotide polymorphism of methylenetetrahydrofolate reductase (MTHFR) rs13306560 may be part of the observed hypertension process in Mexican-Mestizo populations.
26021967 Transcriptional analyses highlighted a strong correlation between the mRNA levels of MTHFR in fibroblasts and COMT genotypes whereas no significant association with MDD was found.
26016497 Results from the case-control study and meta-analysis suggest that both of the two polymorphisms MTHFR C677T and MTRR A66G Polymorphisms are not associated with being overweight/obesity.
25998065 rs114673809, which is located at the miR-214 binding site in the 3'-UTR of MTHFR, may play an important role in the development of gastric cancer in a Chinese Han population.
25987440 thrombo and fibro-genetic mechanisms of PAI-1 4G-4G and MTHFR 677TT, could have a role in the development of liver cirrhosis.
25987236 CYP1B1, KRAS and MTHFR variants are associated with shorter telomere length in postmenopausal women
25981594 MTHFR, TGFbeta1, and TNFB polymorphisms are not significantly associated with the risk of osteoporosis in rheumatoid arthritis.
25981563 For the 5,10-methylenetetrahydrofolate (MTHFR) A1298C polymorphism, the CC variant homozygote genotype was associated with a significantly increased risk of Conotruncal heart defects (CTHDS).
25977387 MTHFR and prothrombin mutations in thrombophilia may predispose for cerebrovascular Aneurysms.
25966188 the A1298C polymorphism and the haplotypes C-677-C-1298 and T-677-C-1298 in MTHFR might modulate the risk of ischemic stroke in the Eastern Chinese Han population.
25966157 this meta-analysis indicates that MTHFR 677C/T polymorphism may not be associated with psoriasis risk
25921104 Genetic polymorphism of MTHFR is associated with lung cancer.
25909872 An association was found in the MTHFR gene variant, rs1801133, with sporadic Parkinson's disease.
25887077 The results might suggest that MTHFR polymorphisms are significantly associated with acute myeloid leukemia risk.
25855559 Single nucleotide polymorphisms in nNOS, renalase, MTHFR, CELSR1 and XYLB genes were found significantly associated with ischemic stroke in Chinese patients.
25855017 SNPs in MTHFR were associated with susceptibility to neural tube defects-affected pregnancy in China.
25846884 Association between MTHFR polymorphisms and alcohol consumption in patients with hyperhomocysteinaemia in an Indian population.
25846410 An SNP in MTHFR gene (C677T polymorphism) has a main genetic effect on the occurrence of obstructive heart defects.
25841988 The meta-analysis suggested that the homozygote TT of MTHFR C677T should be viewed as a protective effect against prostate cancer risk for clinical practice with the consideration of different gene backgrounds, study design and specific controls.
25839940 The meta-analysis suggests that MTHFR C677T gene polymorphism may be associated with premature coronary artery disease.
25835425 This study identified that MTHRF C677T associated with Vascular Dementia
25829992 A strongly significant risk of premature birth was detected in association with MTHFR A1298C polymorphisms.
25824380 Findings showed that there are associations of ACE I/D polymorphism with the susceptibility of a person for development of fibromyalgia syndrome (FM); also, it is determined an association between MTHFR C677T polymorphism and dry eye which are among the clinical characteristics of FM.
25823789 The product of the MTHFR gene plays a significant role in susceptibility to colorectal cancer (CRC) and response to treatment.
25808365 rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
25808073 A significant correlation found between MTHFR C677T polymorphism and neural tube defect (NTD) risk was found in NTD patients and in their mother.
25803740 MTHFR 677C>T polymorphism does not appear to influence the risk of breast cancer.
25802478 Meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of head and neck cancer.
25801727 Analysis of expression level of MTHFR gene showed no statistically significant difference in the pre-eclampsia group as compared to the control group.
25801246 the MTHFR gene and its protein could act as potential predictive biomarkers of BC, especially TNBC among the high altitude Ecuadorian mestizo population.
25796308 genetic polymorphism is associated with allergic rhinitis in children
25793509 MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease.
25793386 the MTHFR polymorphism is associated with an increased risk of male infertility.
25778468 patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR) 677C allele was associated with higher degree of liver toxicity
25761797 The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in acute lymphoblastic leukemia susceptibility.
25758986 MTHFR C677T genotype is associated with increased risk for preeclampsia.
25754229 association between gene polymorphisms of folate cycle (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, and MTRR 66 A>G) and the risk of pulmonary embolism (PE)
25744938 Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II.
25700330 Females with MTHFR 677 TT genotype had a significantly higher risk of NEW-ONSET DIABETES, particularly those with higher BMI or low HDL-C levels
25693213 Also, statistically reliable difference in genotypes distribution by C677T MTHFR gene polymorphism in dependence on homocysteine plasma level and clinical course of ACS severity were established.
25688352 Review of gene association studies of Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 and osteonecrosis of the femoral head (ONFH).
25634595 genetic association study in population in Shaanxi Province, China: Data suggest that a genetic polymorphism in MTHFR (677C>T) is associated with hyperhomocysteinemia in the population studied.
25629981 MTHFR C677T and A1298C polymorphisms are unlikely to affect the development of childhood ALL in an Egyptian population from Delta.
25625218 genetic polymorphism of HCY metabolizing enzymes is correlated to the occurrence of mild cognitive impairment in the Xinjiang Uygur population
25618758 Data show greater ability of rheumatoid arthritis patients with 677CC-1298CC and 677TT-1298AA genotypes to respond to methotrexate treatment.
25598270 The results of this study that in individuals with the CC genotype for the MTHFR C677T variant, migraine frequency was significantly linked to FA consumption.
25591425 Meta-analysis results suggest that MTHFR C677T genetic polymorphism is a probable risk of ischemic stroke
25586317 combination of FVL and MTHFR mutation related to the risk of recurrent fetal death and habitual abortion
25578539 We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility
25566964 MTHFR rs9651118 CC genotype was significantly associated with survival in breast cancer cases (adjusted hazard ratio (HR) = 0.63, 95 % CI 0.40-0.99). But none of the SNPs in the MTHFR gene was associated with serum folate level in healthy controls.
25564416 methylenetetrahydrofolate reductase gene C667T may confer Parkinson's disease susceptibility in Europeans
25560468 The MTHFR 1298A>C polymorphism was associated with gemcitabine chemosensitivity, which require further functional analysis with co-expressed genes
25558689 Carriage of the rare allele of MTHFR-677 2-fold increased risk of adverse pregnancy outcomes.
25551113 Genes encoding 5,10 methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), cystathionine beta-synthase, and folate receptor genes might play a critical role in the formation of the neural tube.
25549181 A higher incidence of MTHFR C677T polymorphism was seen in the Slovak patient group compared to controls. The MTHFR A1298C polymorphism did not differ between patients and controls. Neither polymorphism was associated with complications in the Roma group.
25547204 MTHFR 1298C allele is a risk factor for conotruncal heart disease.
25544674 MTHFR genes were found to be risk factors for unexplained recurrent pregnancy loss.
25544260 This meta-analysis provides evidence that MTHFR C677T polymorphism may contribute to lung cancer development in North China.
25537992 This study suggests that MTHFR gene polymorphisms can not be used as a marker for the assessment of cardiovascular risk in type 2 diabetes mellitus patients.
25536437 The frequency of the MTHFR rs1801133 (C677T) variant alleles was 27.6% and 27.3% for neuroblastoma and nephroblastoma, respectively.
25520092 MTHFR gene polymorphism is not associated with childhood acute lymphoblastic leukemia.
25518505 MTHFR C677T may act as a risk factor of prothrombotic changes in adolescents with Essential Hypertension, by increasing the risk of thrombotic events at an old age.
25510667 Our study shows that the MTHFR 677 C>T polymorphism is significantly associated with the risk of CML in Romanian patients.
25509247 The patient was found to be homozygous for the C677T mutation of the methylenetetrahydrofolate reductase gene, cause of cerebral infarction.
25494855 Results from this study indicate that the MTHFR c.1625A>C genetic variant influences the risk of CHD in the studied population.
25492850 677 TT genotype frequency of MTHFR was higher in rheumatoid arthritis patients (15.1%) compared to the healthy control group
25489783 MTHFR C677T polymorphism is positively correlated with an increased risk of hypertension through an increase in HCY levels
25486592 MTHFR C677T polymorphism may be a risk factor for AD in Asians, APOE 4 carriers, and late-onset AD.
25480409 MTHFR A1298C polymorphism was associated with PE [preeclampsia ]
25472665 MTHFR A1298C polymorphism plays an important role in the development of adult stroke. Genotype CC of MTHFR-1298A/C could increase the risk of stroke and may act as a predictor for clinical evaluation, especially in the Asian population. [Meta-Analysis]
25472587 The MTHFR -677T allele as a susceptibility factor for CHD.
25464772 MTHFR C677 allele was associated with low myocardial growth and high physical performance of athletes.
25458833 This meta-analysis supports that MTHFR C677T polymorphism plays a role in developing essential hypertension--{review}
25453894 A meta-analysis of 38 studies showed that the carriers of the MTHFR 677C-->T variation were more likely to increase the risk of ischemic stroke susceptibility in all-over pooled population, including Asian and European, but not in African populations.
25450284 Asian children with TT genotype of MTHFR gene may have less risk of developing ALL.
25449138 MTHFR C677T polymorphism: epidemiology, metabolism and the associated diseases
25447701 Association of MTHFR genetic variants C677T and A1298C on predisposition to spontaneous abortion in Slavonic population.
25440348 the A1298C polymorphism of the MTHFR gene is not related to ischemic stroke in children
25429430 The MTHFR 677T allele may contribute to an increased risk of metabolic syndrome (MetS] in the northern Chinese Han population. The MTRR A66G polymorphism is not associated with MetS.
25428700 The MTHFR c.677TT genotype may be a genetic risk factor for oligozoospermic infertile male patients who live in the Trakya region of Turkey.
25428529 There was some evidence that plasma tHcy is associated with an increased risk of RVO. There was no evidence to suggest an association between homozygosity for the MTHFR C677T genotype and RVO.
25427015 The studied variants in the MTHFR gene (c.C677T and c.A1298C) do not constitute risk factors for myelomeningocele in this sample of Chilean patients and their parents.
25422209 MTHFR C677T polymorphism is significantly associated with lung cancer in Asians.
25392189 The maternal MTHFR C677T genotype, as a determinant of folate status and 1-C metabolism, is associated with variations in the epigenome of a selection of genes in newborns.
25376315 Increased blood levels of homocysteine related to mutation of the MTHFR gene increase the risk of a thrombotic episode, triggering the development of spinal cord infarction
25375269 This meta-analysis presented a significant association between the MTHFR gene C677T polymorphism and IS, the T allele might be a risk factor for IS in the Chinese
25366783 Data show no significant effect of the 5,10-methylenetetrahydrofolate reductase (MTHFR) A1298C and methionine synthase (MTR) A2756G on the risk of breast cancer, but that MTHFR C667T polymorphism is associated with the risk of breast cancer.
25359311 We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
25342508 Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations. [review]
25341694 Genetic association study of MTHFR C677T polymorphism in oral squamous cell carcinoma (OSCC) risk showed no association with OSCC development.
25339013 MTHFR C667 polymorphism is associated with reduced colon cancer risk.
25331073 MTHFR-rs1801131 is a prognostic factor.
25324196 Results indicate that specific gene variants in ICAM1, PPARGC1A and MTHFR are associated with different non-proliferative diabetic retinopathy phenotypes, being likely candidates to explain different disease mechanisms underlying the different phenotypes.
25317717 In conclusion, based on 13 eligible studies, the result provided strong evidences that MTHFR Ala222Val polymorphism is not associated with POAG.
25316230 The results suggest that polymorphisms of the MTHFR gene may be used as predictors of the response to fluorouracil-based chemotherapy for gastric cancer patients in Chinese population.
25306598 Homozygous variants of genes polymorphisms of MTHFR correlate with the presence of urinary symptoms and recurrence of the rash in children with Henoch-Schoenlein Purpura in the Republic of Buryatia.
25306137 MTHFR 1298C allele is associated with increased skin cancer risk.
25304246 Variants in methylenetetrahydrofolate reductase are common in the general population and in patients with pulmonary hypertension.
25303291 In the title.
25302494 This study provides the first evidence that the MTHFR 677CT/TT genotype-associated lower degree of PBMC L1 methylation increases the risk of CIN 2+ in women in the US post-FA fortification era.
25299110 results indicated significant differences in the frequencies of the MTHFR C677T and A1298C polymorphisms between the two ethnic groups and the Mestizo population of the State of Guerrero
25297611 dietary folate intake was positively associated with plasma folate among those with the CC or CT genotypes and inversely associated with total homocysteine among those with the CC genotype, but associations not clear among those with higher levels tHcy.
25292054 Methylenetetrahydrofolate reductase gene germ-line C677T and A1298C polymorphisms are associated with colorectal cancer risk.
25283235 MTHFR gene variations are not associated with fetrility treatment helping women achieve pregnancy.
25277375 results suggest that 5,10-methylenetetrahydrofolate reductase in the extravillous trophoblast is associated with extratrophoblast invasion
25270516 study found a significant interaction between FGFR2 rs2981582 and MTHFR rs1801133 on breast cancer risk
25265565 maternal MTHFR C677T polymorphism is a risk factor for Down syndrome-affected pregnancy (Meta-Analysis)
25256053 In the maternal analysis, the MTHFR C677T polymorphism was significantly associated with CHD risk (OR = 1.52; 95 % CI = 1.09-2.11; p = 0.01) with significant heterogeneity (I(2) = 63 %).
25246386 genetic polymorphism is not associated with differences in disease control rate and progression-free survival in malignant pleural mesothelioma patients
25232254 Conclude that serum folic acid and MTHFR polymorphisms are not associated with an increased risk of oesophageal adenocarcinoma, although cancers with unstable TT genotype may indicate a more aggressive disease course.
25229416 MTHFR C677T allelic variant is not associated with plasma and cerebrospinal fluid homocysteine in amyotrophic lateral sclerosis
25222234 this meta-analysis suggests that MTHFR C677T polymorphism may not be associated with susceptibility to osteoporotic fracture in postmenopausal women.
25217320 This case-control study found that the MTHFR C677T and MTR A2756G polymorphisms are associated with risk of breast cancer, and folate, vitamin B6, and vitamin B12 intakes influence these associations.
25213548 Using computational biology and online genomic databases, the authors identified two CpG islets that may be important for transcription factor binding and MTHFR gene regulation.
25203152 These results showed that T allele of C677T polymorphism of MTHFR was associated with multiple sclerosis susceptibility in Turkish population.
25176448 The MTHFR 677Tallele is associated with increased total plasma homocysteine concentrations only in males.
25170232 MTHFR C677T polymorphism is a risk factor for gastric cancer, and the A1298C polymorphism may be a protective factor against GC in eastern populations.
25165408 C allele of rs9651118 had significant decreased risk of T2DM. MTHFR rs1801133 was significantly associated with serum levels of tHcy in healthy controls.
25165067 C677T polymorphism significantly affects diastolic blood pressure in Israeli women, independently of blood lipids
25149317 Review/Meta-analysis: data support the associations of MTHFR C677T polymorphism with venous thromboembolism risk in the Chinese population.
25146845 This meta-analysis indicated that C677T polymorphism was associated with altered NHL susceptibility for Caucasians, Asians and FL.
25140779 the SNPs in folate metabolism genes (MTRR and MTHFR) are associated with complex congenital abnormalities and related to ectoderm, mesoderm or endoderm development.
25139692 Results show that individuals with the 5,10-methylenetetrahydrofolate reductase (MTHFR)677TT genotype had a higher risk of acute myeloid leukemia (AML) compared to those with the 677CC genotype.
25124664 the epistasis effects of COMT and MTHFR on inter-individual differences in mental health are consistent with the ''inverted U-shaped'' prefrontal dopamine model
25124382 the MTHFR rs1801133 C/T polymorphism is associated with Coronary artery disease development.
25122721 PAI-1 and MTHFR C677T and A1298C polymorphisms were not associated risk factors in patients who had myocardial infarction with ST-segment elevation and planned to have coronary artery bypass grafting.
25115547 Carrying the T variant of the 677C>T polymorphism of MTHFR.
25115513 an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult Acute lymphoblastic leukemia (Meta-Analysis)
25107455 association between MTHFR rs1801133 polymorphism and susceptibility to stroke
25104092 Methylenetetrahydrofolate reductase polymorphisms are associated with response to chemptherapy in non-small cell lung cancer.
25101272 The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia.
25098357 The MTHFR 677C>T and 1298A>C polymorphisms have restricted roles in the Korean moyamoya disease population
25095657 The risk of rapidly progressing lupus nephritis in systemic lupus (SLE) patients with antiphospholipid syndrome may be associated with MTHFR gene mutation.
25084201 MTHFR, DHFR and ATIC genetic variants can be considered as pharmacogenetic markers of outcome in RA patients under MTX monotherapy.
25081713 The present meta-analysis strongly suggested a significant association between the MTHFR C677T polymorphism and risk of breast cancer in Asian populations.
25080853 The findings provide evidence that C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase are risk factors for chronic myeloid leukemia
25078601 MTHFR C677T polymorphism and folate intake are associated with risk of breast cancer.
25075036 MTHFR C677T T allele was associated with increased risk of breast cancer in Taiwan.
25074646 MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of type 2 diabetes in Han Chinese.
25070812 There was significant association between MTHFR C677T polymorphism and thyroid cancer risk.
25060515 Our findings suggest that there is an association of the MTHFR gene C677T polymorphism with the susceptibility of a person for development of AS.
25055800 epistasis study indicated significant association between ApoE and MTHFR polymorphisms and hypertension
25054348 The present investigation on MTHFR C677T and glaucoma reveals that the TT genotype and T allele of this polymorphism are significant risk factors for Primary Open Angle Glaucoma but not for Primary Angle Closure Glaucoma in North Indian population.
25052622 Maternal risk genotype at rs1801133 predicted higher homocysteine concentration; and lower birthweight
25050994 The MTHFR 677C>T polymorphism may be associated with an elevated risk for cardiovascular disease in end-stage renal disease patients. [Meta-analysis]
25047451 The results of this meta-analysis suggested that MTHFR 677T allele might be a risk genetic factor of type 2 diabetes mellitus in the Chinese Han population.
25041994 there was a trend toward worse DFS among patients with the variant allele of MTHFR C677T compared with wild-type, particularly in treatment arm 2, in which patients with the MTHFR C677T TT genotype had worse overall survival
25036859 By regulating the plasma homocysteine level, the MTHFR C677T gene polymorphism and folic acid level might be involved in the occurrence of the coronary slow flow phenomenon.
25036376 Our results demonstrate that 677T and 1298C alleles are both associated with an increased risk of chronic myeloid leukemia in Algeria.
25031284 The MTHFR C677T polymorphism was not related to small-vessel disease and large-vessel disease, although the TT genotype was an important determinant of hyperhomocysteinemia
25028118 combined analysis of TS VNTR and MTHFR 677C>T SNP revealed shortening of progression-free survival in synchronous carriers of polymorphic tandem repeat sequence allele in TS and two C alleles in MTHFR
25012704 MTHFR gene C677T polymorphism is significantly associated with increased risk of sudden sensorineural hearing loss in European populations, but no statistically significant association was found between the MTHFR C677T gene mutation and the disease in Asian (Meta-Analysis)
25012419 investigated key 1-C-components including the possible effects of antidepressant medication and depressive state, could provide more insight in the possible association between the MTHFR-polymorphism and recurrent MDD
25007516 There is a relationship between the frequency of MTHFR gene C(677)->T polymorphism genotypes and the risk of ischemic stroke in the Ukrainian population.
25007377 meta-analysis suggests that there is a significant association between MTHFR C677T polymorphism and thyroid cancer risk in Caucasians
24990354 interaction of COMT and MTHFR was associated with an increased risk of neural tube defects, especially anencephaly, in a Chinese population
24980946 SELE rs3917412 and MTHFR rs1801133 SNPs could serve as pharmacogenetic predictors of tumor recurrence in patients with early-stage colon cancer treated with oxaliplatin-based adjuvant chemotherapy
24974211 Our data confirmed a high incidence of cerebral abnormalities in neonates born to women with C677T homozygous mutation in the MTHFR gene.
24973876 The findings suggest that the MTHFR C677T polymorphism but not A1298C, and some variants on their combined genotypes or haplotypes may be involved with the development of breast cancer.[meta-analysis]
24970119 The MTHFR A1298C polymorphism is not associated with recurrent pregnancy loss.
24968810 MTHFR C677T genotypes correlate with serum lipids and longevity in a Chinese cohort.
24967362 study suggests that MTHFR C677T and ATIC T675C genotyping combined with clinicopathological data may help to identify patients whom will not benefit from MTX treatment and, therefore, assist clinicians in personalizing RA treatment
24966971 MTHFR 677TT and 1298CC polymorphisms have been associated with risk of chronic myeloid leukemia and higher risk of resistance to therapy.
24945727 The results of this meta-analysis suggest that 677 C>T polymorphism in the MTHFR gene may contribute to breast cancer development
24938371 This study demonstrated that Subgroup analysis by ethnicity indicated that the significant association with schizophrenia and bipolar disorder existed among Asian and African populations, but not for the white.
24932671 The distribution of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in a transhumant (Gaddi) tribal population of Himachal Pradesh dwelling at high and middle altitude and exposed to strong ultraviolet radiation was investigated
24919644 The 677T allele was found protective (odds ratio (OR) 0.21, 95% confidence interval (CI) 0.04-0.94), whereas 1298C allele led to an increase in risk (OR 4.44, 95% CI 2.19-8.99) of childhood acute lymphoblastic leukemia (Meta-Analysis)
24919337 This study found a weak association between T allele in 677 C>T polymorphism in MTHFR and recurrent embryonic loss development.
24913031 Our meta-analysis showed a significant association between MTHFR C677T polymorphism and maternal risk for Down syndrome.[meta-analysis, Review]
24908438 Polymorphism of MTHFR rs1801133 C>T is associated with response to therapy in acute lymphoblastic leukemia.
24906854 elevated tHcy is related to homozygosity for the C677T mutation in the MTHFR enzyme, we explored the MTHFR C677T genotype in the Chinese population.
24903192 a significantly increased risk of cervical artery dissection in individuals with the MTHFR C677T polymorphism by both the recessive model
24898880 MTHFR C677T polymorphism was associated with pre-eclampsia in Asian and white population, but it may not hold true for all populations. [meta-analysis]
24894669 The meta-analysis has indicated a possible association between the CC genotype of methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP rs1801131) and myeloid leukemia in Asian populations.
24864467 No significant differences were found in the distribution of the alleles and genotypes of the NOS3 and MTHFR genes between the groups of chronic hepatitis C patients with slowly and rapidly progressive fibrosis.
24853127 MTHFR rs1801133 and rs1801131 were associated with ischemic stroke risk and MTHFR rs1801133 and rs9651118 may affect serum tHcy levels.
24841934 There is no major role for periconceptional folic acid use and its interaction with the MTHFR C677T polymorphism in the etiology of congenital anorectal malformations.
24839819 Chinese patients with both MTHFR 677TT and MTHFR 1298CC genotypes show increased susceptibility to myeloid leukemia.
24838050 genetic association studies in Han populations in China: Data suggest that an SNP in MTHFR (C677T) is associated with vascular complications in subjects with type 2 diabetes in the populations studied. [META-ANALYSIS]
24828322 A1298C polymorphism has a significant association with diabetes in Asian population but not Caucasians [meta-analysis]
24805831 MTHFR C677T polymorphism is associated with thyroid cancer both in Caucasians and Asians
24798045 MTHFR 677TT genotype and elevated homocysteine levels (even in the upper limits of the normal range of 5-15 mumol/L) are significantly associated with hypertension particularly in the present population, regardless of age and gender.
24797049 The homozygous (TT) genotype of MTHFR gene mutation may be a crucial hereditary risk factor in abdominal aortic aneurysms.
24794492 the MTHFR C677T and A1298C polymorphisms are associated with methotrexate toxicity in rheumatoid arthritis patients [meta-analysis]
24793554 The present study demonstrated an association between plasma homocysteine levels and the severity of coronary heart disease estimated with the Framingham coronary risk score, and this association appeared to be independent on the genotype of MTHFR.
24785111 MTHFR and HFE, but not preproghrelin and LBP, polymorphisms as risk factors for all-cause end-stage renal disease development.
24769206 CDK1/Cyclin B1 phosphorylates MTHFR on T34 and MTHFR plays a role in the heterochromatin maintenance at the centromeric region
24751310 Individuals with the genotype COMT Met/Val and MTHFR C/T have more probability of suffering from MDD
24746944 Polymorphisms within the MTHFR gene are not associated with normal fertilization, good-quality embryo or clinical pregnancy rates.
24744129 There is an association between the MTHFR C677T polymorphism and increased risk of esophageal and stomach cancer, especially among Asians.
24737678 suggest that germline genetic variation in TPMT and MTHFR do not significantly alter SOS risk in patients exposed to thioguanine
24737513 The MTHFR C677T and MTHFR A1298C polymorphisms had additive effects on male infertility.
24737468 mothers who were homozygous for the MTHFR 677TT polymorphism and at risk of abnormal carbohydrate metabolism were more likely to have offspring with spina bifida and high levels of homocysteine, compared to the control group.
24737431 the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.
24725652 This study found suggest an effect of the C677T polymorphism in FEP patients and changes in weight and cholesterol levels. Further investigations in a larger sample are required.
24720776 MTHFR c.382A>G and c.1129C>T genetic polymorphisms...are related with the risk of congenital heart disease in Chinese Han population
24720627 The C677T polymorphism of the MTHFR gene is associated with the susceptibility of ovarian cancer in Asian population, suggesting that TT genotype may serve as a risk factor of ovarian cancer among Asian but not Caucasians
24715181 When Padua score included PAI-1 4G/5G and MTHFR C677T polymorphisms, the sensitivity increased at 71.7%.
24711158 Suggest effects of Italian-style Mediterranean diet/Italian Mediterranean organic diet in chronic kidney patients are influenced by MTHFR genotypes.
24687778 MTHFR polymorphisms are associated with esophageal squamous cell carcinoma.
24678913 A1298C gene polymorphism not associated with type 2 diabetic nephropathy risk [review]
24668238 Genetic study revealed a double heterozygote status in the methylenetetrahydrofolate reductase gene including C677T and A1298C.
24658649 The MTHFR 677T allele is associated with an increased risk of NSCL/P in Asian populations.
24646728 ethnicity modifies the relationship between polymorphisms in the methylenetetrahydrofolate reductase gene and non-Hodgkin lymphoma
24637499 The findings confirm that the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism could be considered as a good marker of the pediatric ALL relapse risk.
24628244 We showed that the C677T polymorphism in MTHFR gene was associated with decreased Parkinson's disease susceptibility in a Han Chinese population from mainland China
24624915 Polymorphisms of the FTO, LEPR and MTHFR genes may play a role in MS.
24624914 MTHFR SNPs rs1801131 and rs1801133 are unlikely to have a clinically meaningful effect on the first 6 months of MTX treatment in early RA.
24616178 We suggest that mild MTHFR deficiency protects against malarial infection and that this phenomenon may have led to the high frequency of the 677C>T/c.665C>T variant in human populations.
24615072 The study suggests a protective role of MTHFR 677TT genotype and high folate intake against gastric cancer.
24611457 MTHFR genetic polymorphisms may be screened to predict the clinical responses to irinotecan-based chemotherapy in CRC patients
24605633 MTHFR 677-TT genotype was associated with the development of pseudarthrosis and increase the proportion of people with hyperhomocysteinemia, high content of inflammatory mediators.
24603976 This meta-analysis found that MTHFR gene C677T polymorphism is significantly associated with increased risk of cerebrovascular disease.
24592886 MTHFR 677C>T polymorphism (CT + TT) was significantly overrepresented among cases with hepatic toxicity (OR = 15.6; 95% CI, 2.6-81.3; P = 0.001).
24588777 it is not necessary for Japanese women to undergo genetic screening C677T mutation of the MTHFR gene as a predictive marker for spina bifida prior to pregnancy, because the TT genotype is not a risk factor for having an affected infant
24586405 Meta-analysis provides evidence that MTHFR polymorphisms are not associated with acute myeloid leukemia risk.
24583625 MTHFR C677T/A1298C genotyping could be useful when using high-dose busalfan for myeloablation.
24577139 Results are the first suggesting a possible association between T833C polymorphism (rs5742905) of the CBS gene and bipolar disorder; data were unable to confirm an association between bipolar disorder and C677T polymorphism (rs1801133) of the MTHFR gene
24569626 the FII G20210A and the MTHFR C677T mutations resulted significantly higher in patients than in controls; in contrast, thrombophilic mutation of FV, ACE, and PAI-1 genes was not statistically correlated with RVO
24566197 the MTHFR A1298C polymorphism is associated with isolated PDA in Taiwan.
24556013 Meta-analysis results indicated that MTHFR C677T polymorphism was associated with an increased risk of epilepsy
24535549 A significant association between the MTHFR C677T polymorphism and schizophrenia.
24535271 These findings suggest that polymorphisms of the MTHFR C677T, GSTM1 and GSTT1 genotypes do not contribute to the development of PTC susceptibility in the Korean population.
24533714 Different MTHFR variants may exist in different tissues to maintain physiological functions and may have implications for disease susceptibility
24532105 Mutation analyses were conducted using the real-time polymerase chain reaction method to screen six common mutations (Factor V G1691A, PT G20210A, Factor XIII V34L, MTHFR A1298C and C677T and PAI-1 -675 4G/5G) found in CVD panel
24532086 The low-penetrance MTHFR 677 C>T mutation reinforces the importance of folate intake to prevent depression.
24522021 In sample of 192 schizophrenics and 213 healthy controls an increasing risk of schizophrenia associated with MTHFR 677 CT+TT genotype was found.
24510388 A population specific variation of MTHFR and hCLOCK genes also highlights ethnicity specific risk management.
24506394 There was no statistical difference in the frequency of the C677T polymorphism OF human MTHFR between homozygous genotype in normal weight and obese
24505291 This meta-analysis suggests that the MTHFR C677T rather than A1298C polymorphism may be associated with H & HIP, especially among East Asians and Caucasians.
24498831 MTHFR val/val genotype has direct effect on increasing plasma homosteine levels but it may not be independent risk factor for late-onset coronary artery disease.
24491881 C-to-T MTHFR mutation contributes only modestly to the hyperhomocysteinemia.
24490800 study found MTHFR A1298C polymorphisms was an independent prognostic factor in patients with neoadjuvantly treated gastric adenocarcinomas but not in adenocarcinoma of the edsophagus nor in primarily resected patients
24488901 MTHFR1298AC gene heterozygous polymorphisms can be weakly predictive for NAFLD severity.
24488626 suggest that MTHFR C677T polymorphism may play a role in oral cancer carcinogenesis in Asian population and heavy drinkers
24484533 C667T polymorphism not associated with recurrent miscarriage
24476575 The MTHFR A1298C polymorphism is associated with susceptibility to childhood acute lymphoblastic leukemia in the Chinese population.
24474455 The MTHFR/p53 genetic combinations AA/ArgArg and AA/ArgPro are associated genetic risk factors for ICC and CIN in Mexican HPV-infected women.
24472005 The data presented here suggest that MTHFR gene polymorphisms may play a vital role in genetic susceptibility to vitiligo
24460828 results indicate that maternal FA intake and the TT genotype of the MTHFR C677T polymorphism in children independently reduced the risk of NSCL/P in our population.
24459043 Predicting Hyperhomocysteinemia by Methylenetetrahydrofolate Reductase C677T Polymorphism in Chinese Patients With Hypertension.
24458267 Individuals with the MTHFR TT genotype had a higher risk of ischemic heart disease, but this association was not modified by folate status.
24456105 The 1298AA genotype in MTHFR gene raises the risk of varicocele approximately 2.3 times more compared with men carrying other genotypes.
24452036 The MTHFR 1298 CC, AC and ACE DD genotypes were associated with diabetic retinopathy and diabetic polyneuropathy.
24449370 C677T seemed to have acquired adaptive developmental plasticity among South Indians due to environmental influences thus contributing to hyperhomocysteinemia and its associated complications.
24447348 Rheumatoid arthritis subjects taking methotrexate may have decreased time-to-SigAE with >/= 1 copy of the minor allele in MTHFR rs1801131.
24440586 Association of methylenetetrahydrofolate reductase (A1298C and C677T) polymorphisms with retinal vein occlusion
24439532 677C/T polymorphism not associated with susceptibility to polycystic ovary syndrome [review]
24424705 The study data indicated that carriage of the MTHFR rs1801131 C allele was associated with body mass index reduction in schizophrenia patients following switching of antipsychotics to aripiprazole and ziprasidone.
24418373 Our study showed that among patients undergoing periprocedural myocardial infarction, MTHFR polymorphism is associated to higher homocysteine levels, but does not influence the risk of periprocedural myocardial infarction.
24393513 examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions and esophageal squamous cell carcinoma
24391036 A meta-analysis supported that the MTHFR A1298C polymorphism could be capable of increasing stroke susceptibility in Asian, but not in Caucasian, populations.
24387084 The MTHFR c.1333C > T genetic polymorphism influences congenital heart disease risk.
24385382 findings from our meta-analysis support the associations of MTHFR C677T and A1298C polymorphisms with hepatocellular carcinoma risk in Chinese population.
24380661 results do not support the hypothesis, that variants in the MTHFR gene confer a risk for NSCL/P in the South Indian population
24379141 meta-analysis shows that the C allele of MTHFR A1298C may be associated with a decreased risk in adult chronic myelogenous leukemia (CML), especially among Asians, while MTHFR C677T may not be associated with adult CML risk
24377532 The MTHFR C677T genotype is associated with risk of ALL in Caucasians.
24373005 The results suggest no major effect of COMT or MTHFR on cognitive function alone. However, an interaction of COMT Val158Met and MTHFR C677T polymorphisms may be associated with cognitive function.
24366618 We found an association of single nucleotide polymorphism C677T in the MTHFR gene polymorphism with male infertility and that it may be a genetic risk factor for male infertility in North Indian population.
24365028 The methylation patterns of the promoters of MTHFR and SNRPN are associated with changes in sperm motility and morphology, which could lead to male infertility.
24363223 Data generated from this study suggest the possible involvement of MTHFR promoter methylation in the pathogenesis of End-stage renal disease and support a new dimension of MTHFR inactivation.
24341140 Mutations of the MTHFR gene have been associated with an increased risk of cerebrovascular disease.
24338416 The maternal MTHFR C677T polymorphism is a risk factor for congenital heart defects in the Chinese Han population. [Meta-analysis]
24338217 single nucleotide polymorphisms in both MTHFR and ABCG2 may have a role in response to FOLFOX/XELOX or FOLFIRI antineoplastic regimens in patients with colorectal cancer
24338216 MTHFR 677-TT homozygous variant, but not -C677T or -A1298C polymorphisms, may have a role in disease progression in chronic myeloid leukemia in Egyptian patients
24337054 The presence of the MTHFR-C677T mutation in fetal blood was consistent with a higher risk of CNS malformations, both in the heterozygous and homozygous forms
24334125 MTHFR C677T polymorphism is associated with male infertility in Jordanians.
24326202 This study found that MTHFR 677C > T genotype, especially in case of no folate supplementation and gestational diabetes mellitus , promoted neural tube defects occurrence.
24320691 There is an association of the MTHFR 677 C>T polymorphism and risk of type 2 diabetes
24316043 Homozygous carriers of MTHFR C677T mutation are more susceptible to hepatocellular carcinoma, but homozygous mutations of MTHFR A1298C may play a protective role for developing HCC.
24310797 study found the frequency of the 1793A allele in the test group was similar to what was found in the control individuals;there was no correlation between G1793A polymorphism and occurrences of early coronary artery disease in this population
24308218 Diabetic nephropathy is influenced by multiple risk factors which can modify the importance of MTHFR polymorphism in its development.
24301776 These data suggest that, in combination with a negative folate balance in glioma patients, T/T genotypes in MTHFR C677T may be associated with MGMT demethylation.
24295761 In Koreans, MTHFR single nucleotide polymorphism confers a genetic predisposition to autism spectrum disorders.
24277487 The results show high frequency of 5,10-Methylenetetrahydrofolate reductase allele associated with high level of Hcy and low levels of folate in an Italian southern population.
24276031 Polymorphisms in methylenetetrahydrofolate reductase gene is associated with secondary mixed phenotype acute leukemia.
24268703 This meta-analysis reveals an association between male infertility and MTHFR C677T polymorphism.
24264431 Significant association between methylenetetrahydrofolate reductase genotype and groups with venous thrombosis, peripheral arterial thrombosis and myocardial infarction. [Meta-analysis]
24254627 MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population.
24242286 The mutant homozygous genotype of MTHFR C677T, was more prevalent in diabetic hypertensive MI patients than it was among non-diabetic normotensive MI patients.
24237708 A significant association was detected between the MTHFR A1298C/ RFC G80A genotype and a nonpredisposition to acute lymphoblastic leukemia.
24229535 These results suggest that the 677C/T MTHFR polymorphism might, along with the -759C/T HTR2C polymorphism and other genetic factors, provide a useful marker for the important and limiting side effect of antipsychotic drug-induced weight gain.
24223459 MTHFR 677C>T polymorphism-especially the presence of one copy of the T allele-appears to confer a potential risk for the development of AD.
24218123 Investigated whether MTHFR C677T mutation is associated with the development of hyperlipoproteinemia and obesity in coronary heart disease. Study was carried out in 82 diabetic and 112 nondiabetic patients with CHD and in 138 CHD-free healthy controls.
24193867 This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of colorectal cancer in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to susceptibility.
24192663 The 677T allele of MTHFR increases PCOS susceptibility, and this relevance seems to be more intense in Europeans than in Asians. [Meta-Analysis]
24183735 The patients with the 677TT genotype of MTHFR showed significantly higher tHcy levels versus those with the wt ones (p=0.049).
24183284 This meta-analysis concludes that the C677T MTHFR polymorphism may act as a genetic susceptibility factor for migraine.
24175799 MTHFR C665T polymorphism is associated with risk of breast cancer. This association was less pronounced among subjects with a moderate intake of vitamin B6 compared to low intake.
24175756 Combined germline variations in PAI-1 and MTHFR C677T genes were associated with genesis of lung cancer.
24155211 MTHFR Ala222Val polymorphism is significantly associated with risk of hepatitis infection but not liver cancer.
24146277 Our meta-analysis supports that the MTHFR Ala222Val polymorphism is not contributed to the risk of ovary cancer
24142599 MTHFR genetic variations analysis would be an innovative tool for the nutritional assessment.
24140489 the MTHFR C667T genetic polymorphism was significantly associated with increased risk of ischemic stroke.
24132798 An interactive effect between the MTHFR 677TT and F2 20210GA polymorphisms showed an increased risk of stroke.
24132589 MTHFR C677T polymorphism is significantly associated with an increased risk of hepatocellular carcinoma.
24130171 Single nucleotide polymorphism in MTFHR gene with LINE-1 methylation is associated with breast cancer.
24129496 This analysis indicated neither folate intake nor MTHFR C677T polymorphism is related to altered susceptibility of ovarian cancer.
24128767 Meta-analysis suggests that there is a significant association between the MTHFR A1298C genetic polymorphism and risk of ischemic stroke, and the C allele probably acts as an important ischemic stroke risk factor
24123968 The results suggest that the MTHFR C677T polymorphism may serve as a marker for major depressive disorder prognosis pending independent replication.
24122207 The current meta-analysis provides strong evidence that the MTHFR C677T polymorphism may be a risk factor for gastric cancer among Asians and Caucasians.
24118377 Data suggest that psoriasis patients carrying of TT genotypes and T allele of MTHFR-677 may be more susceptible to cardiovascular disease and myocardial infarction
24112451 No relationship was found between congenital heart defects and 1298A>C or 677C>T polymorphisms
24108782 genetic association study of population in the United Kingdom: Data suggest that an SNP in MTHFR (677C>T) along with folate status are not associated with DNA methylation in the colonic mucosa of a population without colorectal neoplasia.
24103477 data provide evidence that the MTR A2756G polymorphism increases the level of DNA methylation and confirm the previous reports that the MTHFR C677T polymorphism is associated with DNA hypomethylation
24083702 Polymorphism of MTHFR at 677 and the TA haplotype is associated with the risk of colorectal cancer development.
24078451 during this meta-analysis, we found that MTHFR C677T polymorphism was significantly associated with breast cancer risk in the Chinese population.
24064257 The MTHFR A1298C polymorphism may not increase the susceptibility to Parkinson disease.
24063603 Between the major MTHFR 677 CC genotype, as well as the MTHFR 677 C allele and CT gene is strong association with lung cancer. expression
24052451 Our results suggest a possible association of MTHFR C677T with age at onset of Parkinson's disease
24051448 In this study, the MTHFR C677T and A1298C gene polymorphisms were not associated with nonalcoholic fatty liver disease or the liver disease severity.
24023947 no compelling evidence of an association between the genotype at the rs1801133 polymorphism of the MTHFR gene and risk of type 2 diabetes mellitus
24023349 homocysteine level was not associated with either MTHFR C677T or A1298C, nor with FTO rs1477196, but was inversely correlated with folate status in cancer cases and tended to be higher in patients with the MTHFR 677TT genotype
24015812 functional 1298A>C polymorphism in the MTHFR [5,10-methylenetetrahydrofolate reductase] gene is associated with athletic status. The presence of the C allele seems to be beneficial in sprint-strength and strength athletes.
24014284 Results show an association between carriers of MTHFR 677 allele and elevated homocysteine levels and coronary heart disease
24014085 Asian individuals with the homozygote genotype CC of MTHFR rs1801131 polymorphism are significantly associated with decreased risk of liver cancer.
23996892 Red blood cell folate and MTHFR C677T polymorphism as the genetic modifiers of lymphocytic p53 oxidative lesions of hepatocellular carcinoma patients. The compound MTHFR 677CT/TT genotypes correlated with lower risk of late stage hepatocellular carcinoma.
23992124 MTHFR C677T and FVL G1691A polymorphisms may be risk factors for increased vascular complications in patient with sickle cell disease.
23983171 The factor V Leiden allele increased the risk of Perthes with a pooled OR of 3.10 (95% CI: 1.68, 5.72), while prothrombin II and MTHFR had non-significantly pooled OR 1.48 (95% CI: 0.71, 3.08), and 0.97 (95% CI: 0.72, 1.30), respectively.
23975186 results underscore association between H19 methylation defects and hypermethylation of the MTHFR gene promoter in normal semen samples and suggest aberrant methylation at H19 may occur in the normal sperm of infertile males affected by MTHFR gene dysfunction
23975093 An association between the MTHFR C667T polymorphism and migraine susceptibility was found.
23959833 MTHFR C677T gene polymorphism is associated with meningioma.
23955684 The MTHFR rs1801133 polymorphism is not associated with male infertility in the Spanish population
23954881 The results suggest that MTHFR gene C677T mutation may have an effect on the risk of alopecia areata(AA) in the Turkish population. This is the first study reporting the association between the MTHFR and AA.
23954866 Subjects harboring the MTHFR 677 TT genotype in combination with the CBS 833 TT/homozygous 844 non-insert or the MTHFR 677 TT genotype in combination with the CBS 9276 GA/GG displayed higher Hcy concentrations
23936976 Study shows that the frequency of heterozygous genotype (CT) of MTHFR is higher in osteopenia and osteoporosis than in control subjects amongs postmenopausal Thai women.
23934457 Our results showed a significant association between allele T and decreased risk of gastric cancer.
23933414 Our study demonstrated an association of MTHFR A1298C polymorphisms with congenital heart diseases (CHD) in Egyptian children and their mothers, while, MTHFR C677T polymorphisms were significantly associated with the risk of CHD in the children only.
23916622 our meta-analysis suggests that rs1801133 is significantly associated with susceptibility to PD in European and Asian populations, and MTHFR is likely an authentic risk gene for PD.
23915182 this study demonistrated that the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.
23914427 MTHFR C677T was found to be polymorphic in the Meitei population studied. Around 30% of individuals are carrying the mutant allele either in heterozygous or homozygous condition with T allele frequency of .16.
23901246 A high association between the MTHFR gene C677T mutation and diabetic peripheral neuropathy was observed in the present study.
23900311 SNP rs1801133 allele carriers at increased risk for depressive symptoms or major depressive disorder recurrence after childhood trauma
23897558 the polymorphism of MTHFR C677T but not MTHFR A1298C confers a risk effect on the development of gastric cancer among Asians and Caucasians.
23876493 It was found no evidence for a relationship between CHD and the MTHFR 677TT genotype, which is known to reduce plasma folate, in the largest genetic study of CHD thus far conducted.
23874907 Among MTHFR polymorphisms, c.203G>A and c.1298A>C do not affect infertility risk and c.1793G>A is protective against infertility.
23869894 We suppose that Cr supplementation stimulates pathways leading to production of sarcosine which can serve to regenerate tetrahydrofolate (THF) to form 5,10-methylene-THF.
23869056 The Prevalence of Factor V Leiden (G1691A) and Methylenetetrahydrofolate Reductase C677T Mutations in Sickle Cell Disease in Western India.
23866722 There was no association between tHcy or MTHFR variant and thrombus outcomes.
23865834 the MTHFR C677T and A1298C haplotypes might be useful for monitoring adverse effects in childhood ALL maintenance therapy in Japanese patients.
23865383 Simvastatin can cause a marked decrease in plasma Hcy levels. MTHFR C677T genetic variant contributes to simvastatin's effects among Chinese subjects with primary hyperlipidemia.
23864153 No effects of MTHFR C677T polymorphism on CIN II/III risk and MTHFR A1298C or MS A2756G polymorphisms on cervical cancer risk were detected.
23858518 The smoking group with the T allele has the highest risk of vascular dementia (VD), and synergy appears to exist between the MTHFR gene polymorphisms and smoking in susceptibility to VD.
23856949 MTHFR C677T genotype showed a dose-response association with homocysteine concentration for each additional T allele (Ptrend < 0.01). Birth weight decreased from 120 to 130 grams as maternal homocysteine level increased.
23846816 Studies indicate that the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism may modify the risk for brain tumors, particularly meningioma.
23846111 study observed a significant association of MTHFR C677T with development of diabetic nephropathy in type 2 diabetics; the MTHFR C677T polymorphism plays a significant role in predisposition of renal insufficiency in diabetic patients
23838799 Data suggest that methylenetetrahydrofolate reductase (NAD(P)H), dihydrofolate reductase, thymidylate synthetase and SLC19A1 genes present increased expression after the highest dose of methotrexate in laryngeal cancer cell line.
23831680 In this meta-analysis, MTHFR C677T polymorphism was associated with an increased risk of depression, especially in Asian populations.
23828072 among the four mutations analyzed (factor V Leiden, prothrombin G20210A, and MTHFR 677 C > T and 1298 A > C), only factor V Leiden is a major contributor to thrombosis in polycythemia vera and essential thrombocythemia.
23827456 The MTHFR C677T polymorphism influences the homocysteine level which is an independent risk factor for hyperhomocysteinemia in Tunisian Behcet's disease patients.
23822721 The meta-analysis suggested that MTHFR C677T polymorphism might influence nephropathy risk, but not for diabetes mellitus in the Chinese population.
23819405 Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy. [review]
23816603 The risk of acrocyanosis was significantly higher in patients homozygous for the mutation c.677C>T compared to those with no mutation (OR = 4.8 (95%CI 1.5-14.9)). The homozygosity TT was associated with an increased homocysteine level
23812728 Studies suggest a major role of MTHFR C677T polymorphism in the carcinogenesis of diffuse large B cell lymphoma (DLBCL) among East Asian populations.
23811028 Our data suggested that MTHFR C677T polymorphism plays a role in Chinese migraine susceptibility, especially in migraine without aura.
23807201 colorectal tumour risk is increased in 677TT MTHFR patients with low plasma folate levels
23803097 The methylenetetrahydrofolate reductase C677T polymorphism influences risk of esophageal cancer.
23803092 Homozygotes (TT) of MTHFR C677T had significant risk of hypermethylation of MGMT in gastric cancer.
23787444 Maternal C677T MTHFR polymorphism and environmental factors are associated with cleft palate and cleft lip in a Mexican population.
23774147 The gene polymorphisms of GSTP1 G/G, XRCC1 A/A, and 5,10-MTHFR T/T have clinical value for predicting the response to the DCF regimen for advanced gastric cancer.
23773402 Review/Meta-analysis: suggest MTHFR Ala222Val polymorphism does not contribute to the development of bladder cancer.
23772168 There are no significant differences between the MTHFR C677T genotype and the BMD at the lumbar spine and femoral neck in men or women in both cohorts.
23765760 There is no association between MTHFR 677C>T polymorphism and risk of gliomas. [Meta-analysis]
23760328 Thrombosis in Behcet's disease was associated with a MTHFR homozygous polymorphism.
23759979 In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
23749065 study defined the prevalence of the MTHFR C677T allele in the Chechen and Circassian populations in Jordan; study will contribute to understanding the interaction between genetic and environmental risk factors underlying thrombosis
23736036 Variation in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity.
23731042 We conclude that MTHRF gene polymorphism had no significant effects on postoperative plasma total homocysteine levels
23725631 There was a statistically association between the MTHFR C677T gene polymorphism and nonsyndromic cleft lip and/or palate in the Turkish population
23698160 After folic acid administration, Hcy in both genotype groups decreased approximately to the same level. Similar results were not seen by genotype for admin of 5-MTHF.
23697869 MTHFR polymorphisms had no clear effect on Apo A1 levels
23695205 Higher plasma homocysteine concentrations were observed in persons with the 677TT genotype of the MTHFR gene, but this polymorphism was not associated with muscle mass, strength, physical performance or postural sway.
23692788 mothers carrying 677TT genotype or with 677CT/1298AC combined genotype have increased risk of having nsCL/P offspring; therefore, higher periconceptional folic acid supplementation should be advised for decreasing the recurrence risk.
23692062 In children carrying C677T mutations in MTHFR, higher folate levels were associated with an increased risk of eczema. No interactions between MTHFR and child folate and homocysteine levels were observed for wheezing and asthma.
23687437 Association of LOXL1 with exfoliation syndrome and exfoliation glaucoma was investigated and apolipoprotein E and MTHFR polymorphisms as genetic risk factors for both conditions, were evaluated.
23685927 Our findings demonstrated the susceptible role of the mutant-type MTHFR C677T, MTHFR A1298C, and MTHFD G1958A in recurrent miscarriage.
23685257 these findings suggest that there is an association of IL-4 gene 70bp VNTR polymorphism and MTHFR C677T polymorphism with susceptibility of a person for development of Rheumatoid arthritis.
23679298 MTHFR A1298C polymorphism is associated with esophageal cancer susceptibility.
23665953 As a result, a high association between MTHFR gene C677T mutation and RAS was observed in the present study. Also number of oral ulcers was found to be associated with MTHFR C677T mutation in RAS patients
23659764 The MTHFR A1298C polymorphism is a possible risk factor for Alzheimer's disease
23653228 study indicated that the MTHFR C677T polymorphism contributes to increased autism spectrum disorders risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677C>T polymorphism [meta-analysis]
23652803 MTHFR variant is associated with stomatitis in childhood acute lymphoblastic leukemia.
23649653 The MTHFR Ala222Val polymorphism does not contribute to the development of bladder cancer. [Meta-analysis]
23648444 Heterogeneity between studies was observed, possibly related to differences in MTX dose and leucovorin rescue. In conclusion, in patients with cancer, the MTHFR 677T allele has only a minor role in the development of MTX-induced hepatotoxicity.
23642756 The MTHFR C677T and A1298 polymorphisms (individually or in concert) and hyperhomocysteinemia represent important risk factors for ischemic stroke in Tunisian patients.
23631288 The present study shows that simultaneous presence of MTHFR TT genotype and smoking or elevated levels of LDL-cholesterol influences the risk of premature coronary artery disease.
23626689 Associations of the MTHFR Glu429Ala and ERCC5 His46His polymorphisms with survival were identified in two colorectal cancer patient cohorts. The MTHFR Glu429Ala polymorphism may be an adverse prognostic marker in patients not treated with 5-Fluorouracil.
23608654 riboflavin supplementation targeted at hypertensive individuals with the MTHFR 677TT genotype can decrease BP more effectively than treatment with current antihypertensive drugs only.
23595572 The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of chronic kidney disease.
23593147 Our meta-analysis strongly suggested a significant association of the variant MTHFR C677T.
23586533 data dshow the connection between MTHFR C677T polymorphism, level of homocysteine, illness with schizophrenia and its process; conclude that level of Hcy is higher for a person with the heterozygotic gene with schizophrenia
23578207 The current update analysis suggested that the C677T and A1298C polymorphisms in the MTHFR gene were associated with bladder cancer risk and disease progression.[Review][Meta-analysis]
23550988 The current evidence suggests that individuals with MTHFR 677 variants (i.e. at least one T allele) may have a higher relative risk of pediatric ALL mortality, with greater statistical support for MTHFR 677TT.
23548428 Polymorphic marker CC of the MTHFR gene - genetic predictors of acute disturbance of brain circulation in families of patients with atrial fibrillation.
23547829 There was no relation between liver steatosis with plasma homocysteine levels and MTHFR C677T and A1298C polymorphisms in patients with NAFLD from Northeast Brazil.
23547211 Although MTHFR polymorphisms were previously associated with cardiovascular events in non-rheumatoid arthritis populations, we found only a trend toward decreased association with cardiovascular events in rheumatoid arthritis.
23544272 Report no association between serum uric acid and MTHFR C677T genotype, after the influences of ABCG2 Q126X and SLC22A12 W258X were removed.
23542077 the genetic risk for the inflammatory bowel disease is not modulated by MTHFR C677T polymorphism in Moroccan population
23536781 Both infant and maternal MTHFR C677T polymorphisms may contribute to the risk of CHDs.
23534741 the association of MTHFR C677T polymorphisms with gastric cancer risk
23534726 Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of esophageal squamous cell carcinoma, and folate showed a significant interaction with polymorphism of MTHFR C677T.
23534584 Renal insufficiency in non-diabetic subjects is explained by interactions of MTHFR C677T polymorphism mutation with left ventricular hypertrophy, hsCRP, intact parathyroid hormone, and renal artery resistive index.
23526309 is the first report of MTHFR deficiency in a Korean patient, and one of only a few cases reported in East Asian
23523621 there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and multiple sclerosis
23508410 Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk
23490201 C677T polymorphism of MTHFR gene may increase the risk of cervical cancer in the complete over-dominant model. The association merits replicating and validating in further studies.
23489792 Genetic interaction between MTHFR and MS genes raises the probability of neural tube defects.
23488607 MTHFR C677T polymorphism is important for managing the antifolate dose to reduce toxicity, and potentially influences the prognosis.
23484733 The results of this study imply that the MTHFR C677T and A1298C polymorphisms are associated with the risk of Meniere's disease.
23463763 Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.
23463325 ethnicity-dependent risk factor for cervical cancer occurrence
23460600 Case Report: Brachial artery aneurysm accompanying a homozygous methylenetetrahydrofolate reductase mutation was detected.
23459165 The MTHFR C677T polymorphism has significant effects on susceptibility to prostate cancer in Ecuadorian population, especially with the Gleason grade; on the other hand, a significant association between MTHFR A1298C, MTRR A66G, and MTR A2756G with the pathological characteristics was not found (P > 0.05).
23458876 ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity.
23458174 Methylenetetrahydrofolate reductase (MTHFR) gene mutation was studied in 51 newly diagnosed idiopathic nephrotic syndrome.
23457501 This meta analysis concluded that MTHFR A1298C polymorphism may play a protective role in the carcinogenesis of hepatocellular carcinoma.
23456769 Red blood cell folate increases only with higher additional doses of folic acid supplementation, and this is true for each MTHFR C677T genotype.
23450474 the haplotype (rs1801131, rs1801133) A-C type may be associated with better antidepressant efficacy, particularly in males and patients receiving SNRIs drugs.
23447104 The results clearly showed an association of the ACE I/D polymorphism with the progression of type 2 diabetes mellitus The results clearly showed an association of the ACE I/D polymorphism with the progression of type 2 diabetes mellitus
23444906 MTHFR promoter methylation is associated with cervical severity lesions and with high risk human papillomavirus infection.
23437053 The MTHFR 677 C>T variant genotypes are significantly associated with increased risk of colorectal cancer.
23431363 The MTHFR C677T polymorphism may associate with genetic susceptibility of invasive cervical cancer. [Meta-analysis]
23430981 Haplotype analysis of migraine risk indicates one haplotype block in MTHFR, one block in methionine synthase reductase (MTR), and two blocks in methionine synthase reductase (MTRR).
23429214 Case Report: spontaneous bilateral vertebral artery dissection secondary to PAI-1, MTHFR C677T and ACE gene mutations.
23428159 The meta-analysis suggests that the MTHFR C667T genetic polymorphism was associated with increased risk of hemorrhagic stroke, and the T allele may be an important risk factor for hemorrhagic stroke.
23422951 The MTHFR C677T variant has a protective effect on colorectal cancer development in a population with low allelic variability
23407049 CONCLUSION: MTHFR polymorphisms are not associated with toxicity or efficacy in mCRC patients treated with capecitabine-based chemotherapy.
23401650 No significant differences are found in genotype distributions of angiotensin-converting enzyme and MTHFR C677T polymorphisms between nonarteritic anterior ischemic optic neuropathy and controls
23395424 Results of the meta-analysis suggest that the MTHFR C677T polymorphism was associated with risk of preeclampsia in overall, Caucasian, and East Asia populations
23393023 MHTFR Glu429Ala polymorphism is not associated with breast cancer susceptibility.
23392576 no significant association was observed between the 677C > T and 1298A > C polymorphisms of MTHFR and the prognosis of colorectal cancer patients with curative resection
23391848 The T allele of rs1801133 conferred an increased risk for coronary atherosclerosis.
23385809 While MTHFR 677T and SLC19A1 80G are individually and cumulatively risk factors for nonsyndromic cleft lip with or without cleft palate, SLC19A1 80A appears to be protective against MTHFR 677T risk allele.
23359274 Methylenetetrahydrofolate reductase gene polymorphisms is associated with follicular lymphoma.
23357458 The data of the present study clearly suggests that MTHFR A1298C polymorphism is a genetic risk factor for pregnancy loss.
23353103 COMT and MTHFR polymorphisms interacted on cognition, suggesting that the MTHFR enzyme activity might moderate the effects of the COMT enzyme.
23346725 Two SNPs, both of which are methylenetetrahydrofolate reductase (MTHFR) variants, can affect the way an individual metabolizes folate, resulting in elevated homocysteine level.
23346007 Letter/Case Report: pulmonary thromboembolism due to severe hyperhomocysteinemia precipitated by MTHFR mutation.
23342883 Routine screening for Factor V Leiden (G1691A), prothrombin G20210A and MTHFR C677T gene mutations in patients with a history of recurrent pregnancy loss is not recommended in Turkish women.
23336575 The presence of the mutant MTHFR 1298C and also RFC 80A was linked to a decreased risk of developing chidlhood acute lymphoid leukemia (ALL), and MTHFR 677 was associated with increased risk of ALL.
23329275 This meta-analysis supports an association between MTHFR C677T polymorphism and ovarian cancer risk.
23318463 MTHFR C677T polymorphism may have an effect on the risk of schizophrenia, episodic memory impairment and grey matter density changes in patients.
23314883 The constituent ratio of MTHFR C677T genotype were different in stable plaque group and vulnerable plaque group.
23314385 The frequency of MTHFR A1298C genotype among cerebral venous thrombosis patients was significantly higher compared with controls, suggesting an association between this polymorphism and CVT.
23300023 MTHFR677C>T polymorphism and DNA hypomethylation is associated with neoplasm.
23298970 The C677T MTHFR polymorphism might influence lipid metabolism, obesity, and waist-to-hip ratio in elderly women given short-term folic acid supplementation.
23295071 genetic association studies in women: Data suggest that a polymorphism in MTHFR (C677T) is associated with birthing child with Down syndrome (DS); another polymorphism in MTHFR (A1298C) is not associated with birthing child with DS. [META-ANALYSIS]
23289804 Our results suggest that there may be an association between increased risk for RVO and ACE I/D, MTHFR C677T, PAI-1 4G/5G and factor V Leiden polymorphisms, whereas the Val34Leu variant may exert a protective effect.
23288205 Studies indicate there is growing evidence that MTHFR polymorphism testing has minimal clinical utility and, therefore should not be ordered as a part of a routine evaluation for thrombophilia.
23285280 MTHFR variants and smoking behaviour were associated with homocysteine plasma levels.
23285094 The association of global DNA methylation with nutritional habits, tobacco smoking, body mass index, clinical laboratory parameters, polymorphism C677T MTHFR, functional cognition and the daily practice of physical activity, were evaluated.
23285018 The meta-analysis reveals a negative association between the MTHFR C677T polymorphisms and the cervical lesions.
23276705 The MTHFR gene potentially plays an important role in the pathogenesis of meningioma in the Northern Chinese Han population.
23273201 The T allele frequency of MTHFR (C667T) was found to be a significant risk factor for chronic pancreatitis playing a crucial role in altered folate metabolsim.
23270270 Association of the MTHFR rs7533315 and rs2066462 polymorphisms with coronary artery disease was demonstrated
23255668 This study shows that CC genotype of the MTHFR A1298C is associated with higher risk of MDD in Slovak population.
23247802 MTHFR 677 TT polymorphism may be a potential prognostic factor for cardiovascular disease in patients with Ankylosing spondylitis (AS).
23244112 MTHFR a1298c gene polymorphisms are associated with transitional cell carcinomas.
23238545 The prevalence of methyltetrahydrofolate reductase T677 allele among patients with migraine was significantly higher than in patients without migraine.
23237779 MTHFR 677TT genotype might increase the susceptibility of lung cancer, especially in Asians.
23230240 The MTHFR 677TT genotype was associated with marginally reduced risk of migraine with aura in our older population
23229495 genotype TT of MTHFR C677T have increased risk of vertebral fractures compared those with genotype CT or genotype CC. There is no association between MTHFR C677T polymorphism and risk of hip fractures and non-vertebral fractures.
23227498 MTHFR gene polymorphism is associated with ischemic stroke in a Kyrgyz population.
23227261 These data also indicate the potential importance of the MTHFR gene in the etiology of the attention- deficit/hyperactivity disorder phenotype.
23225055 MTHFR gene 677C/T, 1298A/C and MTRR 66A/G polymorphisms in ethnic Han women from Linyi have differed significantly from other regions of China. Decreased MTHFR activity caused by genetic polymorphisms is a risk factor for raised Hcy level.
23217001 Meta-analysis: MTHFR Ala222Val gene polymorphisms contributed to the breast cancer development.
23207285 no association was found between prothrombin and MTHFR SNPs and thrombosis or ocular involvement in Behcet's disease [review, meta-analysis]
23201630 The methylenetetrahydrofolate reductase 677C>T polymorphism was associated with a higher risk of MS among ischemic stroke patients in the Korean population.
23201418 Results indicate a significant association between methylenetetrahydrofolate reductase (MTHFR) C677T mutation and unexplained recurrent pregnancy loss (URPL) in the East Asian subgroup.
23188888 Both MTHFR and MTRR gene polymorphisms could be important genetic determinants of serum lipid levels in Chinese patients with hypertension.
23186985 This study demonistrated that associations of increased risk for vascular cognitive impairment was found for MTHFR rs1801133 (1.323 (95% CI = 1.061-1.650) p = 0.013); n = 659 cases, n = 981 controls).
23184006 A meta-analysis found that the MTHFR 677C > T polymorphism is a moderate risk factor for Down syndrome for some populations, and populations located in Sub-Tropical region seem to be at greater risk.
23184002 an obvious association between MTHFR C677T polymorphism and hemorrhagic stroke risk, and TT genotype contributes to increased risk of hemorrhagic stroke.
23183616 MTHFR C677T SNP seems to increase the risk of gastric cancer and the effect is significantly inflated by interactions with Helicobacter pylori infection, age and gender.
23183238 Study suggests MTHFR polymorphism as an attractive predictor of MTX-related toxicity in adult ALL.
23174406 This meta-analysis supports that there is an association between MTHFR C677T polymorphism and diabetic nephropathy risk--{review}
23172871 Hyperhomocysteinemia is a risk marker for Indian patients with aseptic CVT. MTHFR 677TT genotype is not linked with CVT but is a determinant of plasma Hcy.
23167392 This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) are not associated with pancreatic cancer risk.
23161188 Hyperhomocysteinaemia was significantly more frequent in migraine patients with the C677T variant, which could be an additional risk factor of this disease.
23155246 this study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms in breast cancer
23145891 methylenetetrahydrofolate reductase polymorphism may modify the effect of hormone replacement therapy on lipid and metabolic parameters in postmenopausal women.
23128422 CT or TT 677 polymorphism in the MTHFR gene is associated with the white matter/watershed injury pattern in neonatal encephalopathy.
23123730 Association between MTHFR C677T polymorphism and primary open-angle glaucoma
23109900 Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.
23108747 The MTHFR polymorphism (C677T and A1298C) resulted in different outcomes regarding homocysteinemia among individuals of each group (diabetic and control) suggesting that metabolic factors inherent to diabetes influence homocysteine metabolism.
23107469 genetic association studies in a population in Romania: Data suggest that 2 SNP in MTHFR (677 C>T; 1298 A>C; as 677CT/1298AC) are associated with myeloproliferative neoplasms (polycythemia vera; essential thrombocythemia; primary myelofibrosis).
23103710 MTHFR C677T polymorphism through affecting on triglycerides level, lipid peroxidation and oxidative stress might be involved in the pathogenesis of severe preeclampsia
23098510 MTHFR C677T polymorphisms are associated with rectal cancer.
23098497 MTHFR C677T polymorphism is not associated with head and neck cancer.
23098496 MTHFR C677T polymorphism is not associated with ovarian cancer risk in Caucasians, but the MTHFR polymorphic variant T may contribute to increased risk in East Asians.
23098468 MTHFR C677T polymorphism is associated with pancreatic cancer.
23095199 No significant differences were observed neither in plasma Hcy levels, RBC folate and vitamin B12 serum levels nor in the prevalence of homozygous and heterozygous MTHFR gene mutation between the two groups studied.
23095111 *Polymorphism, Single Nucleotide Methotrexate/*ADV EFF/THER USE Antirheumatic Agents/*ADV EFF/THER USE the presence of the MTHFR C677T and ABCB1 C3435T SNPs contribute to MTX toxicity in patients with RA.
23090267 Our observations suggest that the C677T polymorphism of MTHFR gene has no direct relationship to erectile dysfunction, but does exhibit a relationship between this rs1801133 polymorphism and plasma LH concentrations.
23089924 The presence of ACE and MTHFR gene mutations/polymorphisms may constitute a risk for developing osteoarthritis.
23076983 The present results do not suggest that the investigated MTHFR polymorphism has any significant influence on age at onset of schizophrenia in the Nordic population.
23070908 the MTHFR C677T polymorphism may not be associated with cervical cancer.
23061880 The results showed that there was a protective effect of the MTHFR C677T variant on ALL risk in Chinese children. [meta-analysis]
23057736 This meta-analysis supports an association between MTHFR 677C>T polymorphism and cervical cancer, and the effect of this association may be race specific.
23056169 Studies indicate a significant association between the Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and neural tube defects (NTD) susceptibility.
23056029 677T allele and 677CT MTHFR genotype may represent a genetic determinant increasing breast cancer risk in Moroccan women.
23054000 Diplotypes of NQO1 (exon 4 and 6), C-T (OR = 1.56, Pc = 0.007) and T-T (OR = 0.011, Pc = 3.86) was associated with an increased risk for prostate cancer (PCa). NQO2 and MTHFR did not show any risk with PCa.
23042008 Homozygous MTHFR C677T and heterozygous prothrombin G20210A mutations are associated with intrauterine skin lesions.
23039890 DNMT3B-579G/T, MTHFR+677C/T and +1298A/C polymorphisms were not correlated with the development or prognosis of AITD.
23036708 might be recommended that MTHFR CC genotype seems to be a good marker for the early identification of population at risk of type 2 diabetes mellitus
23029458 White women with mutant methylenetetrahydrofolate reductase C677T genotypes might have a lower risk of cervical cancer.
23010533 MTHFR promoter hypermethylation is more frequent in semen samples from recurrent spontaneous abortion couples than in semen samples from infertile couples with no history of RSA
22997914 Genetic polymorphism of MTHFR protein considered as potential predictor of severity of metabolic syndrom target organs impairment.
22992862 The hyperhomocysteinemia and the homozygous 677TT MTHFR genotype are risk factors for venous thromboembolism.
22992775 The distribution pattern of MTFHR C677T polymorphism in Eurasia might be the result of interaction of genetic and environmental natural selection, especially the UV radiation.
22982411 did not find significant difference among suicides vs. controls in the prevalence of the MTHFR 677T allele (OR=1.02, p=0.759) or the TT genotype (OR=1.01, p=0.926)
22959498 No significant association was observed for CSK rs1378942 or MTHFR rs17367504 and hypertension in East Asians.
22947400 A founder mutation causing a severe methylenetetrahydrofolate reductase (MTHFR) deficiency has been found in the Bukharian Jews.
22943282 C677T polymorphism and not A1298C, in MTHFR gene is associated with a decreased risk of acute lymphoblastic leukemia.
22940753 Our findings indicate that the polymorphisms in the MTHRF gene are not associated significantly with long-term auditory memory.
22940147 results confirmed that the TT genotype of Glu298Asp in the eNOS gene may be one of the risk factors associated with BSS-IS, while the genotype of 677C-T (Ala-->Val) in the MTHRF gene may not be relevant to BSS-IS
22938732 The MTHFR 677T allele is associated with risk of intracerebral hemorrhage. Those with TT genotype have higher risk of ICH than those with the CC genotype.
22938427 meta-analysis suggested no significant overall association between MTHFR SNP C677T and prostate cancer risk
22938410 frequency of MTHFR 667TT genotype were 37.2 percent in lung cancer cases compared with 23.1 percent in controls; individuals with 667CC/CT genotype displayed reduced risk of lung cancer compared with those with TT genotype; C667T polymorphism may have a significant effect on occurrence of lung cancer in Henan province
22933837 No statistically significant associations were identified between MTHFR and primary angle closure glaucoma in either population.
22928696 The frequency of genotypes MTHFR 677CC, 677CT, and 677TT in idiopathic infertile men with NOA was 43.48%, 41.30%, and 15.22%; 39.29%, 50%, and 10.71% regarding the severe oligozoospermic men; and 42.86%, 45.24%, and 11.90% in the control group
22924497 The polymorphism MTHFR C677T seemed to be possibly predictive of some vascular complications in sickle cell anemia patients in Brazil.
22918664 Vegetarianism is a significant risk factor demonstrating the role of MTHFR C677T mutations among North Indian women who have thrombophilia during pregnancy.
22917961 Our study indicated that the t-allele polymorphism of rs1801133 and the T-C haplotype of the MTHFR gene were associated with the susceptibility to aggressive behaviour in Han Chinese.
22914556 This meta-analysis suggests that the MTHFR C677T polymorphism is capable of causing pre-eclampsia susceptibility in the Asians but not in the Caucasians.
22902176 We found that primary open-angle glaucoma is associated with elevated plasma tHcy levels, but not serum folic acid, vitamin B(12), vitamin B(6) levels, or MTHFR C677T genotype.
22901202 MTHFR polymorphisms (C667T and A1298C) were not associated with pancreatic cancer.
22901194 MTHFR C677T polymorphism and folic acid deficiency is associated with breast cancer.
22901193 MTHFR C677T polymorphism is associated with cervical cancer.
22901166 Methylenetetrahydrofolate reductase gene C677T polymorphism is associated with lung cancer
22897803 It was shown that MTHFR 677 T is a risk allele for decreased kidney function in Chinese males, implicating this gene in the pathogenesis of chronic kidney disease.
22890827 MTHFR C677T polymorphism is associated with decreased risk of colorectal cancer.
22890010 MTHFR 677C>T polymorphism helped determine plasma Hcy concentrations in Parkinson disease
22885990 Among 78 Nepalese blood donors, the prevalence of heterozygous C677T was 31/78. 1 person had homozygous T677T.
22882325 Our results showed the significance of MTHFR A1298C and PAI-1 4G/5G mutations in Iranian women suffering from recurrent pregnancy loss with and without polycystic ovary syndrome.
22875508 Frequencies of MTHFR gene T and C alleles in mothers of patients and healthy children were 65.73% and 46.09%, and 34.27% and 53.91%, respectively (Chi-square=13.663, P<0.01).
22868813 Data suggest that genotypes for the MTHFR C677T and RFC rs1051266 polymorphism might be associated with the risk of conotruncal heart defects.
22856671 Our study suggests that MTHFR 677C>T mutation does not affect the IVF outcome.
22853296 The increased risk for esophageal squamous cell carcinoma (ESCC) was significantly associated with reduced expression of GSTP1, MTHFR, and NQO1, and GSTP1 mRNA showed a steady association with the risk for ESCC in China.
22847888 meta-analysis provided confirmative evidences that infants' MTHFR C677T and A1298C polymorphisms were involved in the development of nonsyndromic orofacial clefts
22846211 MTHFR gene mutations (C677T and A1298C) do not seem to create susceptibility for vitiligo.
22842321 Genotypes and allele frequencies revealed the low prevalence of MTHFR C677T polymorphism in Indin Muslims.
22832733 We conducted a cross-sectional study and assessed the association of the methylenetetrahydrofolate reductase (MTHFR) C677T variant with features of MetS in SGA-treated (n=105) and SGA-naive (n=112) children.
22813657 MTHFR and MTRR polymorphisms are associated with susceptibility to schizophrenia and support the hypothesis of an association between schizophrenia and folate-homocystiene metabolic pathway genes.
22810649 the MTHFR C677T and A1298C polymorphisms are not associated with ovarian cancer risk, especially in Caucasians.
22807619 Description of recurrent ischemic strokes in a young celiac woman with MTHFR gene mutation [case report]
22799374 We found an overall significant, weak inverse association between breast cancer risk and the 677TT genotype and an inverse association with the 1298C variant.
22799306 The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate.
22789065 The C677T and A2756G polymorphisms did not significantly affect antidepressant response.
22782530 Hyperhomocysteinaemia due to the MTHFR 677 C-->T polymorphism is associated with enhanced in vivo lipid peroxidation & platelet activation.
22775456 children with current overactivity had a significantly higher frequency of the MTHFR 677TT genotype (OR=2.77, 95% CI=1.17, 6.60; p=0.02) than those without. This study suggested that MTHFR C677T is a risk factor of autism in Chinese Han children
22773907 There is a high association between the MTHFR gene C677T mutation and Behcet's disease. In addition, response to colchicine is influenced by the MTHFR C677T mutation.
22770603 Men with the MTHFR TT homozygosity had significantly higher tHcy concentration than those with the CC genotype... However, there was no apparent association between the MTHFR polymorphism and self-perceived physical health.
22762524 The methylenetetrahydrofolate reductase Genotype frequencies of CC, CT and TT were 0.727, 0.25 and 0.023 respectively.
22747749 Single nucleotide polymorphisms (SNPs) in arsenic methyltransferase and methylene-tetrahydrofolate reductase is associated with bladder cancer in those exposed to low concentrations of inorganic arsenic. SNPs in glutathione S-transferase omega-1 are not.
22739363 The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
22729883 The MTHFR C667T polymorphism is associated with a reduced risk of colorectal cancer. [Meta-analysis]
22721898 the homozygous MTHFR-C677T genotype varianat did not contribute to the risk of cerebral venous thrombosis in these Tunisian patients
22719222 Meta-analysis suggested that MTHFR 677T allele might provide protection against CRC in worldwide populations, while MTRR 66G allele might increase the risk of CRC in Caucasians.
22713864 data suggest that the methylenetetrahydrofolate reductase 677T allele may increase the risk for premature ovarian failure in Korean women
22711309 the results of the present study suggest that MTHFR 677T allele might play a preventive role for cervical carcinoma among Caucasians. A1298C polymorphisms might exert little effect on cervical cancerigenesis.
22706675 MTHFR and MTRR genetic polymorphisms were not associated with childhood ALL. However, AL was positively associated with homozygosity for any of the MTHFR polymorphisms and carriership of both MTRR variant alleles.
22690662 MTHFR TT genotype females had the lowest DNA methylation level, which may explain metabolic syndrome gender differences in schizophrenia.
22688557 There were highly statistically significant differences in the MTHFR gene polymorphisms between Egyptian patients with venous thromboembolism and controls for CC, TT as well as CC/CT and TT/CT alleles.
22676332 Study found an association between the 677C>T MTHFR polymorphism with hypertension that in women is manifested with age.
22669161 There was no evidence of association between the PHB 1630 C>T and MTHFR 677 C>T polymorphisms with either disease for BRCA1 or BRCA2 mutation carriers when breast and ovarian cancer associations were evaluated separately.
22668858 MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
22664498 Assessment of MTHFR C677T gene polymorphism as a risk factor for coronary artery disease in young Indians.
22660520 homozygous 677T/T MTHFR gene and deficiency of folic acid (FA) intake have been associated with congenital heart disease.
22653243 Higher levels of homocysteine are associated with acute MI and multi-vessel disease in Cypriot patients under the age of 50. The existence and extent of disease are not associated with MTHFR polymorphisms.
22647417 genetic association study in population in China: Data suggest that an SNP in the 3' untranslated region of the MTHFR gene (rs4846049; G<T) is associated with increased risk of coronary heart disease; MIRN149 binding to MTHFR mRNA is altered.
22642106 the alleles of MTHFR and GSTM1 genes may modulate the risk of glucocorticoid-induced (GI)osteoporosis in patients with bronchial asthma.
22628232 investigated the distribution of four inherited polymorphisms in 113 Tunisian blood donors by using PCR-RFLP. The allele frequencies of FVL, prothrombin 20210G>A, MTHFR 677C>T, and MTHFR 1298A>C mutations were 3, 0.9, 30, and 31%, respectively.
22605962 the MTHFR 677TT genotype appears to increase ovarian cancer risk and worsen its prognosis in a Chinese population.
22594584 PCR-RFLP method is a cost-effective and time-saving method. It can be used to successfully genotype subjects for the MTHFR 677 C > T and eNOS +894 G > T and eNOS -786 T > C variants simultaneously with 100% concordance from DNA sequencing data
22576927 significant association with risk of developing CML was found for MTHFR 1298AA and GSTM1 non-null genotypes
22576904 A meta-analysis suggests that the MTHFR 677T allele is associated with lower risk of colorectal cancer in an Asian population.
22555977 The results based on a sizeable group of cases and controls have proved that the 677C>T polymorphism in MTHFR gene is associated with the development of ischemic stroke in children.
22554825 These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes.
22540831 The genotype frequencies at each polymorphic site in the MTHFR 677C>T; 1298A>C; F5 1691G>A and 4070A>G genes and the haplotypes defined by them were not significantly associated with either pre-eclampsia or recurrent pregnancy loss.
22536935 results suggest that MTHFR 677TT polymorphism might be a low-penetrant risk factor for oral carcinoma only in heavy drinkers; conversely, 1298CC alleles might play a preventive role for oral cancer
22536880 The current results are supportive of the hypothesis that the homozygous MTHFR 677TT genotype increases the risk factor of developing thyroid cancer
22533155 MTHFR gene influences enzyme thermolability that leads to its decreased activity and in consequence to elevated level of plasma Hcys in coronary disease.[review]
22528943 A meta-analysis provided evidence for the association between MTHFR C677T polymorphism and increased risk of methotrexate (MTX)-induced toxicities in acute lymphoblastic leukemia patients, whereas the MTHFR A1298C polymorphism was associated with decreased risk of skin toxicity.
22528331 High prevalence of three prothrombotic polymorphisms among Palestinians: factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T.
22524840 MTHFR C677T polymorphism and low folate intake are associated with esophageal squamous cell carcinoma.
22524826 MTHFR C677T polymorphism is associated with the susceptibility of ovarian cancer.
22513795 MTX related toxicity might be influenced by the MTHFR 677C>T or the MTHFR 1298A>C polymorphisms. Differences in MTX toxicity are only partially explainable by these 2 polymorphisms.
22512572 This is a comprehensive summary of the role of polymorphisms in Factor V, Prothrombin, Plasminogen activator inhibitor type-1, Methylenetetrahydrofolate reductase and Cystathionine beta-synthase genes as risk factors for thrombophilias. [review]
22507617 genetic association study in young female Japanese population: Data suggest that MTHFR SNP (677C>T) is associated with hyperhomocysteinemia (and thus with risk of vascular diseases); TT genotype exhibits lower folate and higher homocysteine levels.
22498705 Genetic analysis of MTHFR in the mother of our patient displayed "homozygous C677 polymorphism"
22492374 The inverse association of MTHFR with CVD mortality was significant only in the period after introduction of mandatory folic acid fortification.
22486600 Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy
22479380 Data indicate that genetic variants in folate pathway genes showed associations including infant MTRR 66G>A genotype and maternal MTHFR 677C>T genotype with IGF2 methylation.
22475273 Maternal MTHFR 1298AC genotype was associated with increased odds ratio for aortic valve stenosis, but this association did not meet the higher multiple testing threshold. No association between the MTHFR c.677C.T and heart defect risk was found.
22470444 The average changes in homocysteine levels for MTHFR 677CT and TT genotypes were positive [beta(SE beta), 2.01(0.63) and 16.19(1.8) micromol/L, respectively].
22457816 homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically high significance in severe oligozoospermia group compared with controls
22453148 Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India
22450905 This meta-analysis suggests that maternal MTHFR 677TT genotype might increase the risk of having a cleft lip with or without palate (CL/P) in the white population.
22441130 Frequency of the MTHFR 677T allele is moderately high in AML, ALL and CLL, no statistically significant association was found; on the other hand statistically significant association was found in the context of CML cases.
22440940 The rs1801133 polymorphism did not show significant association with 5-year survival.
22425007 There was no significant relationship between MTHFR C677T polymorphism and plasma homocysteine levels in children and adolescents with epilepsy.
22424391 a novel strong effect of MTHFR 677T among males with nonsyndromic postlingual hearing impairment
22418991 Analysis suggests that the MTHFR C677T polymorphism is unlikely to be a factor contributing to the risk of developing specific forms of glaucoma.
22386772 study replicated two out of nine of the previously reported associations between polymorphisms in drd3 and mthfr gene and treatment response.
22385294 MTHFR C677T and A1298C polymorphisms are genetic risk factors for SALS in women in a gender-specific manner whether they are of spinal or bulbar onset.
22377705 There was a significant decrease in the distribution of T allele in 677C>T polymorphisms among patients with chromosomal abnormalities including both structural aberration and aneuploidy.
22377704 A signi fi cant decrease in femoral neck bone mineral density occurred in association with the MHTFR 677T allele.
22375693 3 MTHFR single nucleotide polymorphisms showing association with migraine in the Norfolk Island population have been identified.
22375042 North Indian urban population with vascular disease has higher homocysteine levels associated with the MTHFR TT genotype.
22373582 Studies suggest that polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) modulate the risk for breast cancer, particularly the A1298C polymorphism of the MTHFR gene.
22370724 A meta-analysis of case-control studies indicates that C677T polymorphism of the MTHFR gene may provide protective effects on susceptibility to prostate cancer risk.
22361411 We report a case of RVT in a newborn who was a heterozygous carrier of both factor V Leiden and the methylene tetrahydrofolate reductase (MTHFR) gene mutation.
22354693 study indicates a link among homocysteine, redox status of plasma Coenzyme Q10, the MTHFR TT677 genotype and levodopa dose in Parkinson's disease patients
22350268 Association between polymorphism of MTHFR A1298C and colorectal cancer risk, is reported.
22342879 the influence of 5,10-methylenetetrahydrofolate reductase C677T polymorphism on folate stability during long-term frozen storage, thawing, and repeated freeze/thawing of whole blood
22329245 results showed no significant differences in the frequency of DAZL AG (P = 0.58) and MTHFR CT (P = 0.44) between oligozoospermic infertile men and controls
22327825 the TT genotype of MTHFR 677C>T increases the risk of the TT genotype of MTHFR 677C>T increases the risk of venous thromboembolism in Koreans.
22313097 This meta-analysis supports the idea that MTHFR C677T genotype is associated with increased risk of RPL, except for Caucasians.
22311035 The MTHFR C677T polymorphism was a risk factor for non-Asians populations, but not for Asian populations.
22303578 MTHFR C677T polymorphism plays an important role in influencing the folate and homocysteine metabolism.
22296369 The C677T variant lies in exon 4 at the folate binding site of the MTHFR gene.
22296361 C677T and A1298C polymorphisms in the MTHFR gene are associated with bladder cancer risk and prognosis.
22292644 Individuals carrying MTHFR 667CT [adjusted odds ratio (OR), 1.95; 95% confidence interval (CI), 1.23-2.62] and TT [adjusted odds ratio (OR), 3.36; 95% confidence interval (CI), 1.46-8.74] had significantly increased esophageal cancer risk.
22286863 A meta-analysis of studies totally 1,470 subjects suggest that the MTHFR C677T polymorphism may be an independent risk factor for hyperuricemia. Review.
22283972 The results suggest that the C677T and A1298C polymorphisms of the MTHFR gene are not related to homocysteine levels in Brazilian patients with Turner syndrome, despite the differential distribution of the mutated allele C (A1298C) in these patients.
22277790 maternal 5,10-MTHFR C677T polymorphism is independently associated with improvement in infant birth weight, especially among nonsmokers. 5,10-MTHFR 1298AA might be associated with folate impairment and interact with tobacco smoke to decrease birth weight.
22277556 The MTHFR 677TT genotype remained a significant determinant of blood pressure, and the elevated blood pressure observed was responsive to riboflavin.
22265089 Metaanalysis suggested that 5,10-methylenetetrahydrofolate reductase A1298C polymorphism is not associated with neural tube defect susceptibility in the white population.
22241680 The current study provides additional evidence that multiple variations in the MTHFR gene are associated with myelomeningocele.
22237773 Common SNP in MTHFR appears to be associated with hypertension. [review-type article]
22230335 There was a protective effect on anencephaly risk only in mothers with 677TT genotype as serum folate levels increased.
22222489 The MTHFR gene homozygote TT mutation is a risk factor for patients with myocardial infarction in the eastern Black Sea Turkish Population.
22219102 The T/T genotype is associated with higher levels of Homocysteine(29% in men, and 11% in women) compared to other genotypes. Nutritional factors affect Hcy levels only in the C/C and C/T MTHFR genotypes.
22218157 We found that the effect of dietary methyl supply on colorectal carcinogenesis may differ according to MTHFR C677T genotype and the subsite of origin in a Korean population.
22217364 results indicate that there was no significant association between the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and psoriasis vulgaris in the Malaysian population.
22215214 No evidence of any associations of MTHFR A1298C polymorphism with lung cancer was found.
22209973 C677T polymorphism in MTHFR gene may be a risk factor for diabetic nephropathy, but not for diabetes mellitus, in a Chinese population. [Meta-analysis]
22203923 The two MTHFR polymorphisms, C677T and A1298C, seemed not related to the onset of ischemic stroke.
22197386 There were no significant differences in allele or MTHFR genotype frequencies between the patients with congenital heart disease and the controls
22194208 A possible association of MTHFR gene polymorphisms C677T and A1298C with risk for colorectal cancer in an eastern Chinese Han population, was analyzed.
22193458 The contribution of polymorphisms, such as MAOA T941G, MTHFR C677T, and TNF-beta G252A, were more important than personality traits in the pathogenesis of migraine, a multifactorial disorder.
22189445 There were interactions between MTHFR polymorphisms and risk of cholangiocarcinoma in Thailand
22187009 MTHFR C677T polymorphism was marginally associated with fracture risk and was modestly associated with bone mineral density of lumbar spine, femoral neck, total hip, and total body.
22176285 Hyperhomocysteinemia more frequent in bipolar I patients independent of C677T polymorphism. TT genotype of C677T MTHFR polymorphism significantly associated with hyperhomocysteinemia and hypofolatemia compared to the CC and CT genotypes in all subjects.
22175540 this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing male infertility susceptibility, especially azoospermia.
22175539 Our results suggested that the fetal and paternal MTHFR C667T gene may be associated with an increased occurrence of CHD
22154679 the MTHFR C677T polymorphism was associated with risk of MI in young/middle-aged Caucasians. [Meta-analysis]
22153546 no association was found between the MTHFR C677T polymorphism and cardiovascular disease in a random sample of the Spanish population
22147263 MTHFR C677T and A1298C single nucleotide polymorphisms were screened in a total of 23 Indian caste, tribal and religious population groups.
22146089 Meta-analysis. In the Chinese Han population, the TT genotype for the MTHFR C677T gene appeared to be associated with increased coronary artery disease risk.
22144047 This study showed an association between MTHFR genotype and risk of clinically significant RP.
22138544 genetic association studies in a North Indian population: Data suggest the an SNP in MTHFR (C677T) is association with recurrent early pregnancy loss.
22132838 Data suggest that methylenetetrahydrofolate reductase (MTHFR) 677 gene variants have no significant influence on the susceptibility to chronic myeloid leukemia (CML) in a Serbian population.
22128864 Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype.
22126580 present meta-analysis provided evidence that MTHFR 677CT/TT plays a carcinogenic role in esophageal squamous cell carcinoma and its effect is modified by tobacco and ethnicity
22126575 The MTHFR gene C677T and A1298C polymorphisms were associated with an increased risk of bladder cancer in a Turkish population.
22116453 our data show association between omphalocele and variants in the MTHFR gene.
22108397 Methylenetetrahydrofolate reductase is responsible for the final metabolic step in the conversion of dietary folate.
22106923 The resutls indicate that the two MTHFR gene polymorphisms are significantly associated with the risk of renal cell carcinomas (RCCs) in a cohort of Pakistani patients and may be useful as susceptibility markers in other populations of the world as well.
22104130 MTHFR 1298A>C polymorphisms and ABCB1 3435C>T, ABCB1 2677G>A/T polymorphisms influenced the efficacy of methotrexate therapy in Japanese rheumatoid arthritis patients.
22103678 Study concluded that both homozygous and heterozygous mutations of MTHFR C677T were related with recurrent pregnancy losses in Caucasian women.
22103601 These results show an evident association between the MTHFR C677T polymorphism and T2DM in Moroccan patients but no significant association with the MTHFR A1298C polymorphism.
22101856 Case Report: homozygous MTHFR mutation in symptomatic patient with an free-floating thrombus in the left common carotid artery.
22094326 current evidence is not sufficient to draw definite conclusions regarding the association of MTHFR variants and development of Acute lymphoblastic leukemia
22084937 Methylenetetrahydrofolate reductase C677T polymorphism is associated with response to vitamin B12 therapy and homocysteine metabolism.
22084413 Prevalence of factor V Leiden G1691A, MTHFR C677T, and prothrombin G20210A among Asian Indian sickle cell patients.
22074251 An important role of polymorphisms and gene-gene interactions within the folate pathway in high dose methotrexate-related toxicity in childhood acute lymphoblastic leukemia.
22056717 An updated meta-analysis demonstrates that MTHFR gene 677TT genotype might confer a moderately augmented risk for diabetic nephropathy and diabetic retinopathy.
22052259 MTHFR polymorphisms and low folate consumption is associated with high DNA adducts resulting in lung cancer.
22044028 The C677T polymorphism in the MTHFR gene is associated with methotrexate toxicity in a Spanish Rheumatoid Arthritis population.
22024018 The MTHFR C677T polymorphism was significantly associated with lung cancer risk.
22023246 Of the 2248 referred patients for molecular thrombophilia workup in Lebanon, 25 (1.11%) had F5, F2, and MTHFR gene mutations simultaneously.
22022190 in the Korean population, the MTHFR polymorphisms are unlikely to be associated with the risk for schizophrenia and neurodevelopmental abnormalities related to schizophrenia.
22017305 Our results in a homogenous population with Kurdish ethnic background indicated that neither the MTHFR 677T allele nor the MTHFR 1298C allele is associated with increased risk of ALL.
22015309 The presence of both MTHFR rs1801133 thymine and IL-6 rs1800795 cytosine alleles increases the odds of developing Alzheimer disease by 2.5 and vascular dementia by 3.7-fold.
22008727 These data indicate the previous observation that MTHFR polymorphisms may play some roles in the pathogenesis and complications of type 2 diabetes mellitus in Caucasians are unlikely to be applied in Taiwanese patients
21997345 heterozygote advantage exists for the MTHFR C677T polymorphism in specific cognitive functions in elderly Chinese males without dementia
21980405 Findings suggest an MTHFR effect on dACC function during error processing, but not on cognitive control during other executive function tasks (working memory or antisaccade generation).
21967996 The MTHFR C677T polymorphism is associated with circulating folate levels irrespective of folate intake.
21956592 Our results suggest that MTHFR genetic polymorphisms might play important role in hepatic carcinogenesis
21956152 neonate did not have a Factor V Leiden mutation detected, but was found to have a heterozygous mutation within the MFTHR gene.
21951971 MTHFR C677T and A1298C gene polymorphisms were not associated with esophageal adenocarcinoma, Barret's esophagus, and reflux esophagitis.
21947961 The variant allele and genotypic frequencies in MTHFR A1298C gene was significantly higher in patients with UC compared to healthy controls.
21942443 A synergistic effect between ACE insertion/deletion polymorphism with either MTHFR C677T or A1298C polymorphism on the increased risk of diabetic nephropathy among patients with type 2 diabetes mellitus.
21934341 The polymorphism C677T of MTHFR is a risk factor for developing colorectal cancer but not cervical, thyroid, and breast cancers
21931346 The available evidence suggests that the MTHFR C677T and A1298C gene polymorphisms are not reliable predictors of response to MTX treatment in RA patients.
21920590 In molar tissue there was a significant reduction in the expected number with the 677TT genotype suggesting the 677C>T SNP may identify a subgroup of molar pregnancies less likely to progress to GTN.
21920473 Donors' MTHFR polymorphisms are significantly associated with the severity of graft versus host disease and decreased patient survival.
21919702 The intrapopulation fixation index of the MTHFR C677T polymorphism was 0.03736. The observed heterozygosity was 0.44 and 0.4 for the general Brazilian and Pomeranian populations, respectively.
21897766 There were no significant differences in genotype distributions of the C677T alleles between the ADHD & control groups. The genotypic pattern of the distributions of the A1298C alleles was different between the ADHD patients & controls.
21878957 677T and 1298C alleles of MTHFR and G80 RFC-1 show association with hyperhomocysteinemia. In contrast, RFC-1 80AA is protective even in presence of 677T MTHFR.
21875371 A contributory role of MTHFR polymorphisms in breast cancer development.
21875294 study provides evidence to support a relationship of increased susceptibility to cholangiocarcinoma in individuals with MTHFR variants, especially for those individuals who have Opisthorchis viverrini infection or consume semi-raw freshwater fish
21868559 Patients with MTR AG/GG in combination with MTHFR CT/TT genotypes carried the highest risk of side-effects
21868135 negative results suggest that the MTHFR c.677C>T polymorphism is not a risk factor for ALS in the Italian population
21861708 Thrombotic events in our patients with Behcet disease were not associated with variations in thrombophilic genes.
21854603 MTHFR C677T polymorphism plays a role in progression of fibrosis and steatosis in hepatitis C patients from Northeast of Brazil.
21853935 Compared with controls, neither FV mutation (3.2% vs 3%; p=0.45) nor the MTHFR 677TT variant (8.4% vs 11.1%; p=0.58) was more prevalent in the patients.
21848426 Results provide support for the role of methylenetetrahydrofolate reductase and thymidylate synthase polymorphism in gliomagenesis.
21845428 Clustering of heterozygous Ala1298Cys and Cys677Thr MTHFR variants is associated with the presence of vascular demyelinization of the white matter of the brain (leukoaraiosis).
21832841 Higher incidence of C677T MTHFR gene polymorphism in girls with urinary tract anomalies points to a developmental difference between the sexes that might be related to sexual dimorphism in methylation.
21819229 The MTHFR gene does not seem to play a role in the etiopathogenesis of attention-deficit/hyperactivity disorder in the cohort studied.
21815801 Mutations related to the MTHFR gene are increased but not statistically significant in Egyptian women with unexplained pregnancy loss.
21810727 Multivitamin use was associated with Hodgkin lymphoma risk among participants homozygous for the MTHFR1298 wildtype allele (AA).
21799811 677C>T substitution associated strongly with male infertility in Indian population
21793799 A stratification analysis showed that the association between the MTHFR C677T polymorphism and the risk of CHD was evident among Caucasians instead of Asians.
21787169 Our early results suggest a role for the common MTHFR C677T variant as a predisposing factors for epilepsy including post-traumatic epilepsy
21781437 No evidence of association between maternal MTHFR genotype and cleft lip or palate was detected
21780915 MTR A2756G polymorphism, but not MTRR A66G and MTHFR A1298C, is associated with risk of coronary heart disease for Europeans.
21775772 MTHFR C677T and MTR A2756G polymorphisms could be an important genetic factor predisposing to idiopathic infertility in Brazilian men.
21774403 MTHFR 677TT genotype increases more than three-fold risk of CL/P and for mothers the risk of having CL/P children may increase two-fold compared with homozygous carriers of MTHFR 677CC genotype.
21773884 MTHFR polymorphisms were associated with methotrexate toxicities in Korean patients with rheumatoid arthritis.
21772318 Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.
21770021 The commonly associated maternal polymorphism 677C>T in the MTHFR gene did not predict risk of NTDs in the offspring (p > 0.05) and 1298A>C and 1781G>A polymorphisms in MTHFR were protective (p = 0.024 and 0.0004 respectively).
21769819 Report no significant association of polymorphisms of the MTHFR gene with the risk of coronary artery disease but allele frequencies differed among cases and controls.
21749215 MTHFR A1298C SNP is more prevalent among south Indians compared with the MTHFR C677T SNP, suggesting a possible role of MTHFR A1298C in the pathogenesis of heart diseases.
21746742 small association of SNP C677T and risk of dementia
21737671 MTHFR C677T genotype may have joint effects with smoking on oral carcinogenesis, and may be a useful biomarker for prediction and prognosis of oral cancer.
21732987 Certain VDR and MTHFR gene polymorphisms increase the risk of basal cell carcinoma development in individuals of Polish origin.
21732284 study concludes that the MTHFR C677T polymorphism slightly increases the risk for colorectal cancer development in the ethnic Kashmir population
21731042 Healthy young women may have higher folate needs due to increasing prevalence of the T allele and reduced folate intake compared with older groups.
21729137 overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility
21725157 the single nucleotide polymorphisms MTHFR C677T and eNOS T-786C, showed a significant effect on the urine 8-isoprostane level in a Japanese population
21723457 This study suggested that methylenetetrahydrofolate reductase mutations in neural tube defects,Metabolism Error, Inborn.
21706313 Creatine kinase MM TaqI and methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms influence exercise-induced C-reactive protein levels.
21702646 [META-ANALYSIS]the 677TT genotype showed a reduced risk of ALL compared with the 677CC genotype in the overall population; for the MTHFR A1298C polymorphism, no significant association with ALL susceptibility was observed
21702266 Plasma homocysteine and MTHFR variants were associated with migraine without aura.
21699409 Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hypertensive adult individuals: a population-based study from Sivas and Canakkale, Turkey.
21681722 We demonstrated no difference in tHcy, folates, vitamin B12 levels and allelic frequencies of C677T and G80A polymorphisms in MTHFR and RFC genes between obese and no obese Tunisian children.
21678004 association between MTHFR C677T polymorphism with ischemic stroke and tHcy levels
21673074 Findings suggest that DNA hypomethylation due to lesser efficiency of polymorphic MTHFR enzymes induces the activation of factors determining proliferation and differentiation of myoblasts promoting muscle growth and increase of muscle mass.
21672255 The study demonstrated that the genotypes ALDH2*2 and MTHFR 677TT conferred elevated risk for developing esophageal carcinoma.
21666966 In human adults with metabolic syndrome geno-typed for polymorphism in the MTHFR gene, uricemia was positively associated with homocysteinemia, triglyceridemia and the habitual alcohol intake
21663380 The MTHFR C677T polymorphism is associated with Alzheimer's disease in Asian populations, but not in Caucasians.
21643754 Meta-analysis suggests that the MTHFR 677T allele might be a low-penetrant risk factor for male infertility, especially in Asian population.
21642818 heterozygosis for the H1299R polymorphism of Factor V, for the C677T polymorphism of MTHFR, and for the 4G/5G polymorphism of PAI-1 may have a role in deep vein thrombosis and inferior vena cava interruption [case report]
21631392 Both elevated plasma homocysteine levels and the MTHFR 677T allele are indicators of increased risk of hemorrhagic stroke in the northern Swedish population
21627615 In Kirghizes carriage of T677 allele of methylenetetrahydrofolate reductase gene was associated with insulin resistance, abdominal obesity, hypertriglyceridemia and low HDL-C level.
21626167 Molecular genetic study was performed, and demonstrated that the patient was heterozygous for the CBS gene with the compound mutations T353 M and D444 N, and homozygous for the mutation C677T in the methylenetetrahydropholate reductase (MTHFR) gene.
21625954 Our data suggests that the polymorphisms FGFR4, MTHFR, and HFE(G388A, C677T, and H63D) are not useful in breast cancer diagnosis, but they may be significant additional prognostic markers related to breast cancer survival.
21624217 The genetic polymorphisms of MTHFR C677T and A1298C are obviously associated with ulcerative colitis in the Han ethnic population.
21613384 Single-nucleotide polymorphisms in MTHFR is associated with chronic kidney disease in hypertensive nephrosclerosis.
21612398 MTHFR 677 CT contributed to elevated risk of cleft lip only, as did MTHFR 677 CT/TT. On the contrary, MTHFR 1298 AC and 1298 AC/CC appeared to be protective against cleft lip with cleft palate.
21607713 These data suggest that both MTHFR C677T and eNOS G894T variants should be regarded as genetic risk factors for hyperhomocysteinemia in patients with cognitive decline.
21605004 the polymorphism MTHFR 677 C-->T showed a significantly increased risk for NSCLC in women but not in men
21603981 These data suggest that all polymorphisms coding for MTHFR, MTR, MTRR and TS have consistent roles in the increased risk of sporadic colorectal adenocarcinoma among the southeastern population of Brazil.
21602719 MTHFR C677T polymorphism is not a risk factor in pediatric thromboembolism
21577095 identified the carriage of the MTHFR A1298C polymorphism as a significant risk factor for vascular-related pregnancy complications
21574459 Gene mutations (C677T in the MTHFR gene, G1691A in the FV gene and G20210A in FII gene) are encountered in diabetic patients more frequently than those in healthy individuals
21567207 All the three gene polymorphisms, namely, MTHFR, MTR and ACE showed significant association with the vascular disease
21556759 The variables age>/=49 years, male gender, tobacco and alcohol habits were associated with MTHFR 1298AC or CC genotypes and increased risk for head and neck carcinoma.
21535009 meta-analysis supports that MTHFR C677T polymorphism is capable of causing male infertility susceptibility in Asians, but not in Caucasians
21534867 Data show that genotyping of MTHFR and measurement of plasma MTX levels might be useful to optimize MTX therapy.
21525199 The maternal methylenetetrahydrofolate reductase (MTHFR) genotype affected childhood spine BMD independently.
21518544 Paternal and maternal MTHFR gene C677T polymorphisms were risk factors for neural tube defects in offspring.
21517266 A significant association was seen between MTHFR 677 CT [adjusted OR (95% CI)=1.55(1.28-1.88)] and TT [crude OR (95% CI)=1.63(1.24-2.15)] genotypes and esophageal cancer.
21516340 Results indicate that these polymorphisms can indirectly influence performance, contribute to higher susceptibility to exercise-induced inflammation or protection against it, and perhaps affect future risks of CVD in athletes.
21508090 MTHFR genotype was an independent predictor of plasma and RBC folate and plasma homocysteine concentrations and did not have a significant interaction with folic acid dose during supplementation.
21507721 MTHFR 677 CT heterozygotes had a higher proportion of good-quality embryos and an increased chance of pregnancy. MTHFR 1793 GA heterozygosity was associated with a lower percentage of previously failed IVF treatments.
21506883 In the present study we identified no association between individual or combined effects of the two common MTHFR genetic variants, 677C > T and 1298A > C, and age at menarche or age at menopause.
21495160 MTHFR C677T, but not A1298C, polymorphism is a potential biomarker for childhood ALL risk.
21489764 Our results provide evidence that the MTHFR polymorphisms might contribute to increased clear cell renal cell carcinoma risk in men
21481373 The MTHFR 677TT genotype is associated with higher serum anti-Mullerian hormone concentrations and has a negative effect on number of oocytes retrieved.
21480888 case report of 2 missense mutations, Gly149Val and Ala116Thr, with acute leukoencephalopathy possibly induced by phenytoin intoxication
21474934 MTHFR was associated with subcortical ischemic vascular dementia, mixed dementia, and lower ChAT activity
21473680 A role for MTHFR and APOA5 as risk factors for Metabolic Syndrome X.
21471424 Our results indicate that MTHFR activity and a specific combination of the MTHFR 1298A>C and TYMS 3'-UTR ins/del polymorphisms are possible predictors of 5-FU treatment-related toxicity.
21462116 Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers
21461956 Polymorphisms in the MTHFR,ApoE,ACE, and LDLR genes, implicated in the pathogenesis of many diseases, including Alzheimers and myocardial infarction, were found to be prevalent in Angami and Lotha Naga populations in India. Lifestyle increase risk.
21461582 This case-control study of postmenopausal women finds no association between either the independent or the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T and MTHFR 1298A>C, and breast cancer.
21460376 MTHFR and TYMS polymorphisms did not show significant association with survival in head and neck squamous cell carcinoma patients
21450592 Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease.
21443409 Independent of maternal age and caloric intake, vitamin B(6) deficiency was associated with 1.8 fold increased risk of DNA hypomethylation in pregnant women carrying the MTHFR 677 T allele.
21441790 MTHFR polymorphisms are associated with pancreatic cancer.
21438757 Linkage disequilibrium (LD) analysis found possible protective role of MTRR 66 AA in sporadic colon cancer. The significant LD between two loci (MTHFR A1298C and MTRR A66G) located on different chromosomes indicates a selective force for their linkage.
21429654 genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in MTHFR (Ala222Val; rs1801133) and an SNP in PEMT (rs4244593) in infertile women with some indication of endometriosis.
21410812 Methylenetetrahydrofolate reductase (MTHFR) 1298A>C polymorphism may be an independent risk factor for spontaneous abortion with fetal chromosomal aneuploidy.
21406306 MTHFR C677T gene polymorphism was neither associated with hemorrhagic nor ischemic stroke.
21394321 data suggest that the MTHFR C677T polymorphism affects the degree of vascular calcification in chronic hemodialysis patients
21385350 Present study found that the MTHFR allele has a favorable effect on a risk of hearing impairment in the middle-aged and elderly population, only when the individuals were of the genotype homozygotes for methionine synthase A2756G.
21380725 Data show that interaction between three alleles of eNOST, MTHFR 677T, and 1298C highly increased the risk of macroalbuminuria and progression of diabetic nephropathy in T2DM patients.
21375764 No significant relation was observed between aberrant DNA methylation of P16, MGMT and hMLH1 gene, as well as MTHFR C677T genetic polymorphisms and the prognosis of esophageal squamous cell carcinoma.
21360915 In CAD patients, particularly in smokers, occurrence of MTHFR and PON1 risk alleles is associated with the decreased adiponectin levels and/or increased degree of insulin resistance.
21358708 participants with the MTHFR-TT genotype had 46% greater odds of cognitive impairment.
21349258 The genotype and allele frequencies of the MTR Asp919Gly, MTHFR Ala222Val, MTHFD1 Arg653Gln and MTRR Ile22Met gene variants did not display statistical differences between patients with cervical cancer and controls.
21347786 MTHFR gene polymorphism is associated with treatment response in locally advanced adenocarcinoma of the esophagus or stomach.
21346782 There is a strong association of methylenetetrahydrofolate reductase gene C677T polymorphism with hypertension and hypertension-in-pregnancy in the Chinese.
21342495 Association between MTHFR C677T polymorphisms and the risk of lung cancer in a Korean population. The T allele was found to provide a weak protective association with lung squamous cell carcinoma.
21338559 MTHFR 1298A-C polymorphism displayed significant interactions with alcohol intake in determining plasma plasma homocysteine.
21334974 Decreases in DNA repair capacity (P<0.05) were observed in C677T and A1298C variants of MTHFR in subject lymphocytes exposed to a water solution of oil fly ash formed by the distinctive transition metals vanadium, iron, and nickel.
21334854 This study provide evidence that the MTHFR 677C > T polymorphism may contribute to the variation in negative symptom response to treatment with folate.
21334398 We postulate that MTHFR polymorphism contributes to the phenotypic variability of Wilson's disease.
21304959 Epistasis between COMT and MTHFR in maternal-fetal dyads; fetal ATCA COMT haplotype and the fetal MTHFR minor "T" allele interact to increase preeclampsia risk; maternal ACCG COMT haplotype was associated with reduced risk for preeclampsia
21302350 The present results suggest that the investigated MTHFR polymorphisms do not influence age of onset in schizophrenia.
21296594 There was no significant association between ACE and MTHFR polymorphisms and stenosis at any site.
21281325 These results suggest the possibility that initiating folic acid supplementation prior to pregnancy may reduce the risk of having a LRD-affected pregnancy, especially in women whose offspring inherit one or two copies of the MTHFR 677T variant.
21270470 The data of this study suggested that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype.
21270364 dietary polyunsaturated fatty acid intake modulates the effect of 2 MTHFR variants on plasma Hcy in Boston Puerto Rican adults.
21269855 serum s-adenosylhomocysteine levels are significantly effected by a combined thymidylate synthetase 3'UTR, and methylenetetrahydrofolate reductase C677T polymorphisms
21269580 MTHFR polymorphisms, C677T and A1298C, are not a genetic risk factor for liver stiffness index in methotrexate-treated rheumatoid arthritis patients.(
21255267 In linear mixed models, MTHFR variants in folate metabolism and age-related cognitive decline are not associated with cognitive change between 79 and 87 years.
21254844 The distribution of NAT2, TPMT, and MTHFR gene polymorphisms in Baja California, Mexico exhibited allele and genotype frequencies that are highly similar to those observed in Caucasian populations.
21241403 The MTHFR 677C/T, and 1298A/C polymorphisms was found to be positively.
21211571 The present study suggests that the 677TT genotype and the TA haplotype in the MTHFR gene may also have a role in colorectal cancer risk in the Czech population, indicating the importance of genes involved in folate metabolism with respect to cancer risk.
21204909 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes
21198396 Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C as maternal risk factors for Down syndrome in Jordan
21190096 the MTHFR 677T allele blunts response monitoring in schizophrenia, presumably via effects on dopamine signaling and dACC white matter microstructural integrity
21190091 Data suggest that the T allele of methylenetetrahydrofolate reductase in multiple sclerosis might be accompanied by higher levels of serum inflammatory mediators and a vulnerability to earlier age of onset of disease.
21186995 Our study shows that MTHFR 677T allele increases the risk of type 2 diabetes mellitus by fourfold in the Indian population.
21185933 This study provides evidence for shared genetic vulnerability for schizophrenia, bipolar disorder and unipolar depressive disorder mediated by MTHFR 677TT genotype--{REVIEW}
21180947 No association between the MTHFR C677T polymorphism and head and neck squamous cell carcinoma was possible in this study.
21178087 MTHFR rs1801133 variant genotypes were associated with an increased CVD risk and there was an interaction between SHMT1 and MTHFR such that the association of the MTHFR rs1801133 CT genotype...was stronger in the presence of SHMT1 rs1979277 TT genotype.
21173738 Data indicate the possible role of MTHFR 1793G>A polymorphism in pathogenesis of recurrent miscarriages .
21159028 Study found no association between MTHFR C677T and A1298C polymorphisms and Down syndrome-related congenital heart disease.
21138341 The data suggest that MTHFR C677T and A1298C polymorphisms could be important genetic factors predisposing to infertility in Brazilian infertile men.
21131308 case report of siblings with recessive spastic paraperesis associated with complex I deficiency due to c596C>T, pA195V missense mutation
21128871 There is a significant correlation between MTHFR 677 TT or CT/TT genotypes and colorectal cancer (CRC) or Bcl-2 promoter CpG island methylation/oncoprotein expression in CRC.
21128869 Data show that methylenetetrahydrofolate reductase variants are involved in homocysteine metabolism, and suggest that individual variability of homocysteine metabolism, e.g. due to genetic variants, may contribute to the vulnerability of ALS.
21125200 genetic association studies: MTHFR SNP (C677T) is associated with depression in an elderly population in Australia
21123458 These data show for the first time in humans that choline itself is a source of methyl groups for de novo PtdCho biosynthesis and indicate that the MTHFR 677TT genotype favors the use of choline as a methyl donor.
21122545 case report of anterior ischemic neuropathy in Crohn's disease with heterozygous A1/A2 polmorphism and MTHFR gene variant
21117954 the MTHFR C677T and A1298C polymorphisms are related with hematologic toxicity and hepatotoxicity, respectively, and could be suggested as prognostic factors for these adverse events.
21113717 We describe two children presenting with presumed cerebral stroke born from two MC twin pregnancies in which the other co-twin had died in utero associated to maternal and fetal homozygosity for MTHFR C677T and MTHFR A1298C, respectively
21113649 the methylenetetrahydrofolate reductase C677T polymorphism is associated with greater risk for sporadic breast cancer
21109973 subjects with the variant MTHFR 677TT genotype appeared to have a significantly lower risk for colorectal cancer than those with the MTHFR 677CC genotype
21104445 Results suggest that methylenetetrahydrofolate reductase and cysthationine beta synthase mutations do not appear to be related to either homocysteine levels or the development of peripheral arterial disease.
21093223 genetic association studies in a population in the Netherlands: investigation of association between MTHFR 677 C>T SNP and schizophrenia
21090237 Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia
21085488 Data show that hypermethylation of the promoter of MTHFR gene in sperms is associated with idiopathic male infertility.
21080081 Comparing lung cancer patients with and without deep venous thrombosis, MTHFR A1298C gene polymorphism differed significantly (P=0.040).
21080081 Observational study of gene-disease association. (HuGE Navigator)
21078611 Observational study of gene-disease association. (HuGE Navigator)
21073356 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21072525 Observational study of gene-disease association. (HuGE Navigator)
21072184 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21070756 the synergistic effects of polymorphisms in the folate metabolic pathway genes in Parkinson's disease susceptibility
21070756 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
21070369 HH and the homozygous genotype in the MTHFR C677T mutation do not seem to play a role in splanchnic vein thrombosis development
21070369 Observational study of gene-disease association. (HuGE Navigator)
21069446 The results associate the MTHFR gene with autism in simplex families only, suggesting that reduced MTHFR activity is a risk factor for autism in these families.
21069446 Observational study of gene-disease association. (HuGE Navigator)
21067440 No correlation was noted between MTHFR genotypes and overall survival, disease stage, bone disease, anemia, and extramedullary disease after multiple myeloma.
21067440 Observational study of gene-disease association. (HuGE Navigator)
21060006 Observational study of gene-disease association. (HuGE Navigator)
21057378 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21055808 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
21052845 Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility.
21052845 Meta-analysis of gene-disease association. (HuGE Navigator)
21052817 the MTHFR variant genotype may increase cervical intraepithelial neoplasia and cervical cancer risk in women with low folate or vitamin B12 status.
21052817 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21051057 In nonalcoholic patients with CHC mild liver steatosis is frequent, and is associated with hyperhomocysteinemia. An association between steatosis and MTHFR-C677T polymorphism was not found
21051057 Observational study of gene-disease association. (HuGE Navigator)
21050834 Single Nucleotide Polymorphism in MTHFR is associated with differentiated thyroid carcinoma.
21050834 Observational study of gene-disease association. (HuGE Navigator)
21048041 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21046286 Genotypes of MTHFR were associated with increased risk of muscle-invasive bladder transitional cell carcinoma.
21045733 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
21045271 the methionine synthase A2756G SNP A/G or G/G genotype and the methylenetetrahydrofolate reductase C677T SNP T/T genotype were considered double genetic risk factors for elevated homocysteine levels
21045271 Observational study of genotype prevalence. (HuGE Navigator)
21044746 Methylenetetrahydrofolate reductase polymorphism (677 C>T) predicts long time to progression in metastatic colon cancer treated with 5-fluorouracil and folinic acid.
21044746 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21044744 Role of methylenetetrahydrofolate reductase gene polymorphisms (C677T, A1298C, and G1793A) in the development of early onset vasculogenic erectile dysfunction: a case control study.
21044744 Observational study of gene-disease association. (HuGE Navigator)
21042205 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
21041608 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
21039385 Observational study of gene-disease association. (HuGE Navigator)
20979787 Genetic polymorphism of MTHFR G1793A was strongly associated with ulcerative colitis and hyperhomocysteinaemia.
20979787 Observational study of gene-disease association. (HuGE Navigator)
20978181 Observational study of gene-disease association. (HuGE Navigator)
20977771 The differences in serum TC, TG, LDL-C and ApoB levels between the two ethnic groups might partly result from different genotypic and allelic frequencies of the MTHFR C677T or different MTHFR gene-enviromental interactions.
20977771 Observational study of gene-disease association. (HuGE Navigator)
20970119 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20962791 MTHFR gene polymorphism is a potential risk factor for cerebral palsy combined with mental retardation.
20962791 Observational study of gene-disease association. (HuGE Navigator)
20962453 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20960113 homocystein levels were higher than normal subjects in patients with polycystic ovary and MTHFR C677T gene polymorphism does not influence homocystein levels of patients
20960113 Observational study of gene-disease association. (HuGE Navigator)
20960050 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20957490 DNA methylation in CDKN2A associated to the MTHFR 677T carrier is suggested to be a distal tumor characteristic, especially in those 60 years old or older, and it seems to depend on the infection by H. pylori cagA/vacAs1m1 strains.
20955826 The MTHFR 677C>T SNP and the MTRR 66A >G SNP were identified as determinants of impaired bone mineral density (total body) in childhood acute lymphoblastic leukemia patients.
20955826 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20948192 Observational study of gene-disease association. (HuGE Navigator)
20946434 Carriers of the MTHFR 677T allele may have an increased risk for chronic cluster headache.
20946434 Observational study of gene-disease association. (HuGE Navigator)
20944139 the C allele of MTHFR C677T may be associated with the development of prostate cancer
20944139 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20941748 genetic association studies between MTHFR SNPs and Graves' disease (GD) in Chinese subjects: 677CT and TT genotypes are associated with reduction in risk of GD in women
20941748 Observational study of gene-disease association. (HuGE Navigator)
20940365 gene-environment interactions between high alcohol intake and the MTHFR 677TT genotype for elevated oral cancer risk, with a significant impact on multiple methylation of cancer-related genes.
20940365 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20939734 The MTHFR C677T and CBS 844ins68 variants tested in this study, individually or combined, are not associated with cardiovascular disease in the Algerian population.
20939734 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20939248 Observational study of gene-disease association. (HuGE Navigator)
20935614 Observational study of gene-disease association. (HuGE Navigator)
20935396 The MTHFR 1298CC genotype is an additional genetic risk factor for idiopathic male infertility in an Indian population.
20935396 Observational study of gene-disease association. (HuGE Navigator)
20935060 Observational study of gene-disease association. (HuGE Navigator)
20926035 MTHFR C677T gene polymorphism may contribute to insulin resistance in Han Chinese with MS by increasing hs-CRP and decreasing vitamin B12, and consequently play an important role in development of MS-associated T2DM.
20926035 Observational study of gene-disease association. (HuGE Navigator)
20923444 Data support MTHFR polymorphisms as independent prognostic markers in oral carcinoma, with C677T polymorphism influencing oral cancer susceptibility, and A1298C polymorphism associated with patient prognosis.
20923444 Observational study of gene-disease association. (HuGE Navigator)
20920350 SHMT1 1420 and MTHFR 677 polymorphisms are associated only with development of rectal and not colon cancer
20920350 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20890936 Mothers exhibiting the A variant allele (GA genotype) of the MTHFR rs2274976 polymorphism demonstrated a ~6 times increased risk for having a child with nonsyndromic cleft lip and/or palate in the Brazilian population.
20890936 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20890573 We confirmed that gene alterations increase risk for pathology
20890573 Observational study of gene-disease association. (HuGE Navigator)
20888556 No association was found between MTHFR/MTRR genetic variants and sperm counts.
20888556 Observational study of gene-disease association. (HuGE Navigator)
20887110 The MTHFR 677TT genotype is considered to be a definite risk factor for development of neural tube defects
20887110 Observational study of gene-disease association. (HuGE Navigator)
20883119 Observational study of gene-disease association. (HuGE Navigator)
20881312 MTHFR C677T-mutant genetically predisposes its carriers to SVT which may contribute to hypercoagulation in pre-existing varicose vein disease.
20881312 Observational study of gene-disease association. (HuGE Navigator)
20880607 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20870238 Established a simple and effective capillary electrophoresis (CE) method for detection of two SNPs in MTHFR gene simultaneously.
20863444 Genetic polymorphisms OF MTHFR are associated with MTX-related adverse effects in the treatment of rheumatoid arthritis.
20863444 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20861582 The MTHFR 677TT genotype had decreased risk of prostate cancer (OR = 0.50, 95%CI: 0.28-0.88) compared with 677CC genotype;the 677T allele was more likely to exert a protective effect on prostate cancer risk (OR = 0.73, 95%CI: 0.56-0.96)
20852445 Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans
20852445 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20852008 Observational study of gene-disease association. (HuGE Navigator)
20842733 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20841390 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20831652 No association with MTHFR gene polymorphism and homocysteine plasma levels could be found in patients with HSP.
20831652 Observational study of gene-disease association. (HuGE Navigator)
20825473 the MTHFR 677C>T polymorphism does not contribute to the distribution of cervico-cerebral atherosclerosis in ischaemic stroke patients
20825473 Observational study of gene-disease association. (HuGE Navigator)
20825051 Contrary to numerous suggestions in various publications, we did not confirm the correlation between MTHFR 677C>T polymorphism and the influence on the risk of ovarian cancer in BRCA1 mutation carriers in the investigated group of Polish women
20825051 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20824655 Observational study of gene-disease association. (HuGE Navigator)
20819778 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20819423 Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients.
20819423 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20817226 MTHFR SNPs C677T and A1298C are not associated with ovarian cancer risk.
20817226 Observational study of gene-disease association. (HuGE Navigator)
20812180 Observational study of gene-disease association. (HuGE Navigator)
20808944 the effect of maternal MTHFR C677T genotype on antenatal maternal mood, and their impact on the gene-specific methylation
20808944 Observational study of gene-disease association. (HuGE Navigator)
20800057 MTHFR 677T and 1298C alleles increased the susceptibility to the onset and progression of diabetic nephropathy in Iranians with type 2 diabetes mellitus.
20798492 Observational study of gene-disease association. (HuGE Navigator)
20737570 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20734048 Observational study of gene-disease association. (HuGE Navigator)
20726304 Observational study of gene-disease association. (HuGE Navigator)
20724652 Observational study of gene-disease association. (HuGE Navigator)
20723587 Observational study of gene-disease association. (HuGE Navigator)
20721969 Polymorphisms of methylenetetrahydrofolate reductase are associated with a high risk of nasopharyngeal carcinoma.
20721969 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20718043 Observational study of gene-disease association. (HuGE Navigator)
20717043 Observational study of gene-disease association. (HuGE Navigator)
20714149 Observational study of gene-disease association. (HuGE Navigator)
20707730 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20707729 Observational study of gene-disease association. (HuGE Navigator)
20696177 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20694488 This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.
20694488 Observational study of gene-disease association. (HuGE Navigator)
20694154 Observational study of gene-disease association. (HuGE Navigator)
20692813 These findings suggest that MTHFR polymorphisms are unlikely to be related to the development of schizophrenia in the Japanese population.
20692813 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
20687780 Observational study of genotype prevalence. (HuGE Navigator)
20673868 Observational study of gene-disease association. (HuGE Navigator)
20672355 No significant associations between the C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms and neural tube defects were found in Slovakia.
20672355 Observational study of gene-disease association. (HuGE Navigator)
20672350 Observational study of gene-disease association. (HuGE Navigator)
20670920 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20670473 results confirmed that the methylenetetrahydrofolate reductase(MTHFR) 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum homocysteine levels which is bad for cognitive function
20670473 Observational study of gene-disease association. (HuGE Navigator)
20670164 Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20669348 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20664391 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20663228 Observational study of gene-disease association. (HuGE Navigator)
20661822 MTHFR677C>T polymorphism does not seem to have significant role either in susceptibility or survival of esophageal squamous cell carcinoma in a northern Indian population.
20661822 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20657745 Observational study of gene-disease association. (HuGE Navigator)
20647221 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20644561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20641100 The MTHFR genotype contributed to global DNA hypomethylation in fetal brain tissue which in turn is associated with Neural tube defects-affected pregnancy.
20641100 Observational study of gene-disease association. (HuGE Navigator)
20639647 Compared to those in the stratum of 40 or more weeks of gestation, those with the TC/TT genotypes of MTHFR C677T in the stratum of 37 or less weeks of gestation had a significantly increased risk of premature rupture of membranes in preterm delivery.
20639647 Observational study of gene-disease association. (HuGE Navigator)
20638924 Observed allelic frequencies were: TSER, (2) 0.54 and (3) 0.46; MTHFR C677T, (C) 0.59 and (T) 0.41; p53 Arg72Pro, (Arg) 0.73 and (Pro) 0.27; MDR1 C3435T, (C) 0.52 and (T) 0.48.
20638924 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20637366 The TT genotype from the C677T of 5,10 MTHFR gene is not an independent risk factor for STEMI in the Mexican population. However, more studies are needed to determine the possible "protective effect" of the C677T polymorphism in our population
20637366 Observational study of gene-disease association. (HuGE Navigator)
20637011 Observational study of gene-disease association. (HuGE Navigator)
20634891 Observational study of gene-disease association. (HuGE Navigator)
20634689 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20615707 This study identified a possible association between the presence of at least one V allele in MTHFR A222V and concurrent stenoses.
20615707 Observational study of gene-disease association. (HuGE Navigator)
20608880 The common MTHFR 677 C->T mutation seems to represent a link between altered early growth and enhanced degree of insulin resistance that occurs later in obese adolescents.
20608880 Observational study of gene-disease association. (HuGE Navigator)
20608153 Observational study of genotype prevalence. (HuGE Navigator)
20602615 Observational study of gene-disease association. (HuGE Navigator)
20600372 This meta-analysis supports that MTHFR C677T polymorphism is capable of causing AD susceptibility in East Asians, not in Caucasians.
20600372 Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator)
20595278 Data suggest that methylenetetrahydrofolate reductase genotyping may have a predictive value for the risk of methotrexate-associated toxicity in patients with juvenile idiopathic arthritis.
20595278 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20594233 Observational study of gene-disease association. (HuGE Navigator)
20593383 Observational study of gene-disease association. (HuGE Navigator)
20592457 Reduced occurrence of the single nucleotide polymorphisms in MTHFR is associated with hypertension, thrombophilia and oxidative stress in mexican populations.
20592457 Observational study of genotype prevalence. (HuGE Navigator)
20592453 MTHFR polymorphisms were not associated the stability of the enzyme configurations in Down syndrome patients.
20592453 Observational study of gene-disease association. (HuGE Navigator)
20589617 C677T MTHFR gene polymorphism does not affect folic acid, vitamin B(12) and homocysteine metabolism in Turkish children with NTDs
20589617 Observational study of gene-disease association. (HuGE Navigator)
20580582 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20580032 study demonstrated a positive association between homocysteine and adiponectin in both elderly men and women and a statistically significant association between adiponectin and MTHFR C677T genotypes in women only
20580032 Observational study of gene-disease association. (HuGE Navigator)
20572854 most significant associations with nonsyndromic cleft lip with or without cleft palate (CL/P) were found for SNPs in MTHFR, including several common haplotypes in the MTHFR genes.
20572854 Observational study of gene-disease association. (HuGE Navigator)
20571252 The importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which was shown in a randomized controlled trial and other studies was independently confirmed by a large-scale GWAS.
20565774 Observational study of genotype prevalence. (HuGE Navigator)
20564317 MTHFR 677TT and 1298CC genotypes were associated with an about 40% reduction in risk of prostate cancer compared to the 677CC, and 1298AA genotypes. The 677TT genotype was associated with more than 50% decreased risk of high-grade prostate cancer.
20564317 Observational study of gene-disease association. (HuGE Navigator)
20559280 Observational study of gene-disease association. (HuGE Navigator)
20552676 the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant bipolar disorder.
20552676 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20551579 In a Thai population, colon cancer risk was associated with environmental factors and interactions between MTHFR polymorphisms and these factors.
20551579 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20550866 In this population, genotype C677T was not a major risk factor for this malformation, however, sample size, other genes implicated and genes-environment interactions must be considered
20550866 Observational study of gene-disease association. (HuGE Navigator)
20549016 Germ line polymorphisms in the folate- and methyl-associated genes MTHFR, MTR and MTRR, were analyzed in colorectal cancer patient cohort to find a possible link between these genetic variants and p16 hypermethylation.
20549016 Observational study of gene-disease association. (HuGE Navigator)
20547447 These data provide evidence supporting an association between MTHFR and risk of metabolic syndrome in patients with schizophrenia.
20547447 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20544798 Observational study of gene-disease association. (HuGE Navigator)
20536507 Observational study of gene-disease association. (HuGE Navigator)
20534746 Total intake of choline and genotype can influence the concentrations of choline and its metabolites in the breast milk and blood of lactating women and thereby affect the amount of choline available to the developing infant.
20534746 Observational study of gene-disease association. (HuGE Navigator)
20534741 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20532637 a methylene-tetrahydrofolate reductase gene polymorphism has a role in non-small cell lung cancer
20532637 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20532609 Environmental factors played a more important role in urothelial carcinoma carcinogenesis than MTHFR or methionine synthase (MS) gene polymorphism.
20532609 Observational study of gene-disease association. (HuGE Navigator)
20530282 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20530057 Study investigated an association between MTHFR polymorphism tHcy concentrations and coronary syndrome severity.
20530057 Observational study of gene-disease association. (HuGE Navigator)
20524928 MTHFR has 677T allele, together with C/T and T/T genotypes in Lebanese but not Bahraini diabetic nephropathy patients, thereby conferring diabetic nephropathy susceptibility.
20524928 Observational study of gene-disease association. (HuGE Navigator)
20523222 MTHFR A1298C genotype may explain part of the individual liability to metabolic disturbances in patients with schizophrenia.
20523222 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20518725 Data support a strong relationship between migraine and major vascular diseases and suggest an important role of ACE and MTHFR system in the pathogenetic model of migraine.
20518725 Observational study of gene-disease association. (HuGE Navigator)
20516537 frequency of the MTHFR 677 TT genotype is rare as compared tothe genotype in the population studied. There was no association between 677 C-->T and 1298 A-->C polymorphisms and risk of colorectal carcinoma either individually or in combination
20516537 Observational study of gene-disease association. (HuGE Navigator)
20515362 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20514079 Identification of MTHFR genotypes for C677T and A1298C polymorphisms could lead clinicians to identify patients in risk of elevation of transaminases, and give them an individualized treatment, as is a goal of pharmacogenetics.
20514079 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20504979 Maternal MTHFR 677T allele is an independent predictor of poorer child neurodevelopment at 24 months.
20504979 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20504332 Case-control study in Korea found a protective effect of the MTHFR C677T variant genotype for gastric and colorectal cancer.
20504332 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20504250 Observational study of gene-disease association, gene-environment interaction, pharmacogenomic / toxicogenomic, and genetic testing. (HuGE Navigator)
20502473 Folate intake was not correlated with plasma levels in subjects with the MTHFR 677 T/T genotype.
20502473 Observational study of gene-disease association. (HuGE Navigator)
20492738 No statistically significant association was found between the methylenetetrahydrofolate reductase C677T gene mutation and sudden sensorineural hearing loss.
20492738 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20484876 Meta-analysis of gene-disease association. (HuGE Navigator)
20479641 Observational study of gene-disease association. (HuGE Navigator)
20479155 Observational study of gene-disease association. (HuGE Navigator)
20473868 MTHFR single nucleotide polymophrism increases risk of hyperhomocysteinemia and of esophagus and gastric cancer and with decreased risk of colorectal cancer.
20473868 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20472929 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20471108 Observational study of gene-disease association. (HuGE Navigator)
20470942 Meta-analysis of gene-disease association. (HuGE Navigator)
20467892 Polymorphisms in MTHFR gene is associated with breast cancer.
20466634 Data show that MTHFR 677C>T and MTRR 66A>G polymorphisms are two independent risk factors for DS pregnancies in young women, but RFC-1 80G>A and MTR 2756A>G polymorphism are not independent risk factor.
20466634 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20464958 Polymorphism of MTHFR and p53 found in Down' and Elers-Danlose syndrome cells may explain radiosensitivity in Down and Elers-Danlo syndromes patients.
20464958 Observational study of gene-disease association. (HuGE Navigator)
20458436 Observational study of gene-disease association. (HuGE Navigator)
20456312 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
20452800 Observational study of gene-disease association. (HuGE Navigator)
20452482 Observational study of gene-disease association. (HuGE Navigator)
20449891 A case of recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR-677C>T and 1298A>C gene and hyperhomocystenemia.
20447924 The SLC19A180G in MTHFR is associated with colorectal cancer.
20447924 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20447923 High amount of folate intake and genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase were associated with significantly better survival in advanced gastric cancer patients treated with fluorouracil-based chemotherapy.
20447923 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20446941 Mutations not associated with spontaneous cervical artery dissection.
20446941 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20445573 Our results suggest that the effects of methylenetetrahydrofolate reductase C677T and methionine synthase A2756G gene polymorphisms may have pivotal roles in the aetiology of essential hypertension and blood pressure response to benazepril.
20445573 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20445408 MTHFR CT/TT polymorphisms have a reduced risk of acute lymphoblastic leukemia.
20445408 Observational study of gene-disease association. (HuGE Navigator)
20441995 The MTHFR C677T polymorphism (mainly TT genotype) is associated with developing vascular dementia in general populations or Asian populations.
20441995 Meta-analysis of gene-disease association. (HuGE Navigator)
20440228 The association between MTHFR C677T polymorphism and autism spectrum disorders through a case--control study, was evaluated.
20440228 Observational study of gene-disease association. (HuGE Navigator)
20437058 Observational study of genetic testing. (HuGE Navigator)
20433440 the T allele of the MTHFR gene may have a role in vascular and congenital kidney failure
20433440 Observational study of gene-disease association. (HuGE Navigator)
20429317 plasma total homocysteine was significantly higher in patients with venous thromboembolism than in controls; 677C-->T mutation on MTHFR gene heterozygosity was higher in patient group than in controls but this difference was not significant
20429317 Observational study of gene-disease association. (HuGE Navigator)
20428919 Observational study of genetic testing. (HuGE Navigator)
20425806 Observational study of gene-disease association. (HuGE Navigator)
20423475 Our results show that the MTHFR 1298 A>C gene polymorphism confers an increased risk for subclinical atherosclerosis and CV events in patients with rheumatoid arthritis.
20423475 Observational study of gene-disease association. (HuGE Navigator)
20421849 Observational study of gene-disease association. (HuGE Navigator)
20421795 MTHFR T/T homozygotes are more sensitive to the combination of low folate intake, low plasma folate and vitamin B12 level, than patients with non-T/T genotypes.
20421795 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20418067 This study found no support that maternal/child MTHFR C677T genotype and maternal folate intake during pregnancy contribute to common aetiological pathways that are shared between schizophrenia and non-clinical psychotic symptoms in adolescents.
20418067 Observational study of gene-disease association. (HuGE Navigator)
20417243 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20416077 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20414254 Observational study of gene-disease association. (HuGE Navigator)
20413850 Observational study of gene-disease association. (HuGE Navigator)
20409583 MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis.
20409583 Meta-analysis of gene-disease association. (HuGE Navigator)
20406848 These results suggest that the higher cardiorespiratory fitness may attenuate central artery stiffening associated with MTHFR C677T polymorphism.
20406848 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20400894 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20390408 Observational study of gene-disease association. (HuGE Navigator)
20388089 Observational study of gene-disease association. (HuGE Navigator)
20386493 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20385995 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20381446 no association with colorectal cancer risk
20381446 Observational study of gene-disease association. (HuGE Navigator)
20378615 Observational study of gene-disease association. (HuGE Navigator)
20374669 MTHFR c.1793G>A may have a role in susceptibility to sporadic congenital cardiac disease.
20374669 Observational study of gene-disease association. (HuGE Navigator)
20374299 Observational study of gene-disease association. (HuGE Navigator)
20374270 protective effects of combined MTHFR 677CC/1298AC genotypes on susceptibility of adult B-ALL are gender biased toward women with 677CC/1298AC women being at a 17-fold reduced odds to develop B-ALL
20374270 Observational study of gene-disease association. (HuGE Navigator)
20373852 Observational study of gene-disease association. (HuGE Navigator)
20371218 The C/C variant of MTHFR C677T polymorphism suffer a four times higher risk of multifocal lesions in the breast cancer patients treated with adjuvant therapy.
20371218 Observational study of gene-disease association. (HuGE Navigator)
20368715 Observational study of gene-disease association. (HuGE Navigator)
20367562 Increased frequency for MTHFR C677T is associated with acute lymphoblastic leukemia.
20367562 Observational study of gene-disease association. (HuGE Navigator)
20363151 Observational study of genotype prevalence. (HuGE Navigator)
20357240 Observational study of gene-disease association. (HuGE Navigator)
20357201 Observational study of gene-disease association. (HuGE Navigator)
20351714 Observational study of gene-disease association. (HuGE Navigator)
20346360 Observational study of gene-disease association. (HuGE Navigator)
20346029 Squamous cell carcinoma was hypomethylated compared with adjacent non-neoplastic skin & patients with MTHFR polymorphism had higher levels of global methylation in tumours and non-neoplastic skin compared with those without the MTHFR polymorphism.
20346029 Observational study of gene-disease association. (HuGE Navigator)
20335551 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20331623 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20310006 no association was observed with respect to MTHFR C677T and A1298C, RFC A80G, and TYMS polymorphisms and risk of retinoblastoma
20310006 Observational study of gene-disease association. (HuGE Navigator)
20302034 In AAA,the pooled ORs for the C677T variant of 5,10-methyltetrahydrofolate reductase (MTHFR) were 1.34 (95% CI, 1.08 to 1.65; P = 0.007) for the dominant model and 1.16 (95% CI, 0.81 to 1.67; P = 0.41) for a recessive model.
20302034 Meta-analysis of gene-disease association. (HuGE Navigator)
20298385 Observational study of gene-disease association. (HuGE Navigator)
20237949 Observational study of gene-disease association. (HuGE Navigator)
20237899 an increase in MTHFR 677TT genotype only in ascertained gastric cancer (GC) cases, but not on GC-relatives (13.5% vs controls 14.1%, Tables 2 and 3).
20237899 Observational study of gene-disease association. (HuGE Navigator)
20236116 We found four novel mutations in hyperhomocysteinemia patients, three of which were missense changes c.664G> T (p.V218L), c.1316T> C (p.F435S) and c.1733T> G (p.V574G), and the fourth was the 1-bp deletion c.1780delC (p.L590CfsX72).
20235210 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20229631 Diagnostic effectiveness of molecular-genetic markers (polymorphisms in APOE, ACE (I/D) and MTHFR (C677T) genes)is not sufficient for evaluation of risk factors for cardiovascular diseases.
20229089 Results suggest that MTHFR polymorphisms play no significant role in susceptibility to ONFH in the Korean population.
20229089 Observational study of gene-disease association. (HuGE Navigator)
20223480 MTHFR 677C/T polymorphism is associated with cognitive performance in Spanish adolescents.
20223480 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20221815 Age, diet, and MTHFR gene polymorphisms were related to homocysteine level.
20221815 Observational study of gene-disease association. (HuGE Navigator)
20220206 In men with the MTHFR 677CC genotype, choline intake affected (P = 0.007) the change in DNA methylation...
20220206 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20216541 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20213658 T allele of MTHFR C677T could be associated with susceptibility to SSNHL, and even imply that this mutation could be a risk factor that is independent of blood folic acid and homocysteine.
20213658 Observational study of gene-disease association. (HuGE Navigator)
20209990 Patients with hyperhomocysteinemia (HHcy) had statistically significant increase of allele MTHFR 677T and MTRR 66GG as compared both with the control group and with the group of patients without HHcy.
20209990 Observational study of gene-disease association. (HuGE Navigator)
20204402 Observational study of gene-disease association. (HuGE Navigator)
20203488 The T allele from the C677T polymorphism of the MTHFR gene represents an independent risk factor for idiopathic ischemic stroke at young age in the Mexican-Mestizo population.
20203488 Observational study of gene-disease association. (HuGE Navigator)
20193847 Among the genotypes found in our samples, MTHFR CT and CT+TT were associated with increased risk for CRC incidence. Among the 151 tumors tested, 36 (23.8%) were microsatellite instable positive.
20193847 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20191019 Study demonstrates that the MTHFR 1298A>C polymorphism is a risk factor for SBI in a Korean population.
20191019 Observational study of gene-disease association. (HuGE Navigator)
20186013 Observational study of genetic testing. (HuGE Navigator)
20185366 Observational study of gene-disease association. (HuGE Navigator)
20180013 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20177420 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20175737 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20163778 Data show that a polymorphism of the BDNF gene is positively associated with depressive disorder, but no other significant associations of depressive disorder or metabolic syndrome were found with variants of MTHFR, eNOS, or tyrosine hydroxylase.
20163778 Observational study of gene-disease association. (HuGE Navigator)
20162297 Observational study of gene-disease association. (HuGE Navigator)
20161734 Meta-analysis of gene-disease association. (HuGE Navigator)
20160465 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20160191 Meta-analysis of gene-disease association. (HuGE Navigator)
20155847 the 677T-MTHFR allele frequency increases as photoperiod increases at conception.
20155847 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20154341 These data confirm a recent finding that CPS1 is a locus influencing homocysteine levels in women and suggest that genetic effects on Hcy may differ across developmental stages.
20154341 Observational study and genome-wide association study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20146887 There was no association between MTHFR gene variants and methylation status of the RASSF1A gene in the 45 bladder cancer patients.
20146887 Observational study of gene-disease association. (HuGE Navigator)
20146869 No significant differences were found in mean age, body mass index, homocysteine levels, or MTHFR allele or genotype distributions between obstructive sleep apnoea syndrome patient and control groups.
20146869 Observational study of gene-disease association. (HuGE Navigator)
20143151 This meta-analysis suggests that the MTHFR T allele is a low-penetrant risk factor for developing breast cancer.
20140262 Observational study of gene-disease association. (HuGE Navigator)
20135343 Concluded that potentially functional MTHFR C677T polymorphism may play a low penetrance role in the development of breast cancer.
20134102 single-nucleotide polymorphisms in the MTHFR gene is associated with progression of carotid atherosclerosis.
20130515 A decreased risk for cervical intraepithelial neoplasia of individuals homozygous for the MTHFR T allele was shown.
20122156 The proportion of individuals who are homozygous for the 2R allele of the 5'UTR TYMS polymorphism is less in individuals who are homozygous for the T allele of MTHFR 677 than in individuals homozygous for the C allele of MTHFR 677.
20113291 In Yemeni children with sickle cell disease the frequency of the MTHFR C677T mutation was not higher than expected in the general population and was not associated with disease severity.
20113291 Observational study of gene-disease association. (HuGE Navigator)
20111745 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20106900 Observational study of gene-disease association. (HuGE Navigator)
20101025 Observational study of gene-disease association. (HuGE Navigator)
20097536 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20088379 Observational study of gene-disease association. (HuGE Navigator)
20085490 Meta-analysis of gene-disease association. (HuGE Navigator)
20082468 MTHFR, TGFB3, and TGFA polymorphisms have roles in non-syndromic cleft lip and cleft palate in different regions of China
20082468 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20082058 Observational study of gene-disease association. (HuGE Navigator)
20078877 Observational study of gene-disease association. (HuGE Navigator)
20078613 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20076818 MTHFR mutations are significantly associated with survival in colorectal cancer.
20076818 Observational study of gene-disease association. (HuGE Navigator)
20075510 MTHFR 677C>T polymorphism is not likely to be a maternal risk factor for Down syndrome in our cohort
20075510 Observational study of gene-disease association. (HuGE Navigator)
20071789 was no association between MTHFR 677 C-->T and 1298 A-->C gene polymorphisms and risk of lymphoblastic leukemia
20071789 Observational study of gene-disease association. (HuGE Navigator)
20068371 Higher levels of plasma homocysteine, even mildly elevated ones, could be associated with nonischemic retinal vein occlusion and pigmentary glaucoma, especially when related to genetic risk factors or C677T mutation.
20067328 Our meta-analysis including found no association between polymorphisms of MTHFR and the toxicity and efficacy of methotrexate in rheumatoid arthritis--REVIEW
20067328 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20066895 an inverse association of the MTHFR 677TT genotype with colorectal cancer, in particular at high levels of folate.
20066895 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20066615 The 677C > T and 1298A > C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for spina bifida occulta in Turkish patients.
20066615 Observational study of gene-disease association. (HuGE Navigator)
20066125 Observational study of gene-disease association. (HuGE Navigator)
20065615 C677T polymorphism in the MTHFR gene, high homocysteine and low HDL cholesterol plasma have roles in heterozygous familial hypercholesterolemia
20065615 Observational study of gene-disease association. (HuGE Navigator)
20065319 MTHFR C677T genotype, but not the A1298C, was differently distributed between the lung cancer and control groups.
20065319 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20064497 Observational study of gene-disease association. (HuGE Navigator)
20056627 677 TT and 1298 CC genotypes of the MTHFR gene may each be associated with a decrease in colorectal cancer risk.
20056627 Observational study of gene-disease association. (HuGE Navigator)
20047525 maternal C677T polymorphism but not A1298C polymorphism significantly associated with increased risk for neural tube defects
20047525 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20044984 Our results suggest that deficient MTHFR enzyme activity in pregnant women, related to the A1298C variant, is associated with a higher risk of having offspring affected with schizophrenia.
20044984 Observational study of gene-disease association. (HuGE Navigator)
20044141 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20039875 results suggest that the MTHFR genotypes and haplotype might be useful, in a gender-specific manner, as predictive factors for the clinical course of clear cell renal cell carcinoma in Japanese patients.
20039875 Observational study of gene-disease association. (HuGE Navigator)
20037199 Results suggested that at least one C to T polymorphism at 677MTHFR gene is required to significantly increase the risk for CRC development.
20037199 Observational study of gene-disease association. (HuGE Navigator)
20031640 CHDH A119C and MTHFR C677T play an important role in modulating the homocysteine levels in Indian population.
20031578 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20031554 Observational study of gene-disease association. (HuGE Navigator)
20031128 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20030812 Study provides support that the MTHFR 677TT genotype is associated with a moderate increase in risk of postmenopausal breast cancer and that this risk may be attenuated with high intakes of some one-carbon associated nutrients.
20030812 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20027027 Observational study of gene-disease association. (HuGE Navigator)
20021850 The low level of folacin intake during pregancy is a risk factor of congenital heart disease and the MTHFR 677TT genotype is correlated to congenital heart disease.
20021850 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20017223 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20012180 Observational study of gene-disease association. (HuGE Navigator)
20010155 Observational study of gene-disease association. (HuGE Navigator)
20003837 association of the MTHFR c.677C > T genotype with plasma homocysteine levels was weakened by other factors that impact homocysteine levels
20003837 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20003469 Observational study of gene-disease association. (HuGE Navigator)
20002681 the MTHFR polymorphisms might contribute to reduced childhood acute lymphoblastic leukemia risk.
20002681 Observational study of gene-disease association. (HuGE Navigator)
19996639 Type 2 diabetics who are homozygous or heterozygous for the MTHFR C677T gene polymorphism showed normal tHcy levels.
19968891 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19967163 Observational study of gene-disease association. (HuGE Navigator)
19963111 frequency of the MTHFR A1298C CC homozygous mutant genotype was significantly higher in patients with follicular lymphoma than in control subjects. No such association was found for the heterozygous A1298C AC genotype
19963111 Observational study of gene-disease association. (HuGE Navigator)
19961055 No association was found between MTHFR C677T polymorphism and risk in women with recurrent abortion.
19961055 Observational study of gene-disease association. (HuGE Navigator)
19959486 Patients with VWD carrying defective alleles of MTHFR(677C/T) showed milder phenotypes than expected.
19959486 Observational study of gene-disease association. (HuGE Navigator)
19956635 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19954568 The present review will investigate the evidence linking the MTHFR C677T polymorphism to BP and the potential modulating role of B-vitamins.
19954067 MTHFR genetic polymorphisms,and dietary intake of folate may modify susceptibility to breast cancer.
19954067 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19952781 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19948975 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
19947517 The frequency of gamma-induced chromosome aberrations was correlated with the total amount of minor alleles in loci MTHFR.
19947517 Observational study of gene-disease association. (HuGE Navigator)
19940469 MTHFR mutation does not seem to be a significant risk factor for thromboembolic events in beta-thalassemia major
19940469 Observational study of gene-disease association. (HuGE Navigator)
19939410 MTHFR genotype was not a risk factor for developing schizophrenia, although a larger sample is required to confirm this finding.
19939410 Observational study of gene-disease association. (HuGE Navigator)
19939360 No difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677 T) was found in 100 infertile women
19939360 Observational study of gene-disease association. (HuGE Navigator)
19937485 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19937354 In this cohort of diabetic subjects, mild hyperhomocysteinemia and the MTHFR TT genotype are not significant risk factors for the development of macroangiopathy.
19937354 Observational study of gene-disease association. (HuGE Navigator)
19936946 these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer
19936946 Observational study of gene-disease association. (HuGE Navigator)
19936026 The methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genotypes and plasma concentrations of total homocysteine (tHcy) in Pakistani patients with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG), was investigated.
19936026 Observational study of gene-disease association. (HuGE Navigator)
19935819 Maternal riboflavin intake is significantly associated with biomarkers of the homocysteine pathway, with the strongest effects in MTHFR 677TT homozygotes. The maternal risk of having OFC offspring, however, is not associated with dietary riboflavin intake
19935819 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19934566 Observational study of gene-disease association. (HuGE Navigator)
19934565 In the Iraq population studied MTHFR C677T TT genotype was a significant risk factor for ischemic stroke and it was related to the increased total homocysteine levels
19934565 Observational study of gene-disease association. (HuGE Navigator)
19934557 MTHFR C677T gene polymorphism associated with a predisposition to hyperhomocysteinemia could constitute a useful predictive marker for ischemic stroke in type 2 diabetic Chinese patients.
19934557 Observational study of gene-disease association. (HuGE Navigator)
19930673 Meta-analysis of gene-disease association. (HuGE Navigator)
19926119 This meta-analysis confirmed that there is currently insufficient data supporting that 677TT genotype is a risk factor for cerebral venous thrombosis.
19926119 Meta-analysis of gene-disease association. (HuGE Navigator)
19925624 Meta-analysis of gene-disease association. (HuGE Navigator)
19923983 MTHFR TT genotype is significantly associated with increased mucosal and hepatic toxicity during methotrexate therapy as well as increased relapse rate in childhood ALL.
19923983 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19923980 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19917450 a significant association between hyperuricemia (SUA > or =7mg/dL) and MTHFR 677T allele carriers was observed
19917450 Observational study of gene-disease association. (HuGE Navigator)
19917061 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913857 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19910873 MTHFR C677T polymorphism was not associated with geriatric depression or cognition. The MTHFR CT and TT genotypes are associated with greater WML volume at a given age, suggesting that the effect on WML volume may be related to other aging-related changes
19910873 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19909951 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19906129 Observational study of gene-disease association. (HuGE Navigator)
19898482 Observational study of gene-disease association. (HuGE Navigator)
19894660 MTHFR polymorphism can be considered a susceptibility gene for this congenital heart disease
19894660 Observational study of gene-disease association. (HuGE Navigator)
19893205 There is no association of polymorphisms related to MTHFR gene with non-complicated overweight or obesity.
19893205 Observational study of gene-disease association. (HuGE Navigator)
19885596 polymorphisms in TYMS, MTHFR, p53 and MDR1 may have roles in breast cancer
19885596 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19860767 Observational study of gene-disease association. (HuGE Navigator)
19858780 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19858398 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19857676 Observational study of gene-disease association. (HuGE Navigator)
19857655 Observational study of gene-disease association. (HuGE Navigator)
19857476 Data suggest that angiotensin-converting enzyme I/D polymorphism may act synergistically with methylenetetrahydrofolate reductase C677T polymorphism in diabetes risk.
19857476 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19854238 The genotype frequencies of the missense variant MTHFR c.1298A>C were significantly different between patients and controls. Homozygosity for the A allele of MTHFR c.1298A>C may be protective against the incidence of MS.
19854238 Observational study of gene-disease association. (HuGE Navigator)
19853891 Observational study of gene-disease association. (HuGE Navigator)
19853876 CYBA and APOE polymorphism showed a different distribution in the groups studied, while no differences were observed in MTHFR C677T polymorphism
19853876 Observational study of gene-disease association. (HuGE Navigator)
19852428 Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism.
19846961 Observational study of gene-disease association. (HuGE Navigator)
19846566 The investigators performed a meta-analysis on the the association between the MTHFR 677TT polymorphism and the risk of colorectal neoplasms and found a reduced risk in some populations.
19846566 Meta-analysis of gene-disease association and gene-environment interaction. (HuGE Navigator)
19846322 Hyperhomocysteinaemia, low folate concentrations and homozygous C677TT mutation in the MTHFR gene were the risk factors in the development of acute mesenteric venous thrombosis.
19846322 Observational study of gene-disease association. (HuGE Navigator)
19843671 MTHFR polymorphisms are associated with colorectal cancer.
19843671 Observational study of gene-disease association. (HuGE Navigator)
19839754 this study supports the association between MTHFR C677T and patients with early recurrent pregnancy loss among north Indian Rajputs and strengthens the notion that thrombophilia plays a role in this clinical entity.
19839754 Observational study of gene-disease association. (HuGE Navigator)
19838916 A case-control study in Japan failed to find significant associations between polymorphisms of MTHFR or MTR (methionine synthase) genes and breast cancer risk.
19838916 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19838435 Observational study of gene-disease association. (HuGE Navigator)
19837268 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19827168 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19826759 Observational study of gene-disease association. (HuGE Navigator)
19826048 Observational study of gene-disease association. (HuGE Navigator)
19825913 No association was found between RVT and the C677T MTHFR genotype.
19825913 Observational study of gene-disease association. (HuGE Navigator)
19824427 Observational study of gene-disease association. (HuGE Navigator)
19817293 A relationship may exist between the SNP of MTHFR 677 C/T and alcohol induced osteonecrosis of femoral head.
19817293 Observational study of gene-disease association. (HuGE Navigator)
19814618 it has been observed that C677T polymorphism of the MTHFR gene produces no statistically significant difference for T allele frequency and the genotype frequency in prostate cancer patients and male controls
19814618 Observational study of gene-disease association. (HuGE Navigator)
19812220 Observational study of gene-disease association. (HuGE Navigator)
19810824 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19805823 results suggest that the MTHFR 677C>T polymorphism may be considered as a genetic risk factor of childhood stroke, especially in boys
19803295 We attempted to assess the association between NTDs and MTHFR C677T in Malaysian Malay population. Results show that MTHFR 677TT genotype was absent in both patient and control groups.
19799358 Observational study of gene-disease association. (HuGE Navigator)
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19777601 Observational study of gene-disease association. (HuGE Navigator)
19776634 Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.
19776634 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19776610 Observational study of gene-disease association. (HuGE Navigator)
19775302 Meta-analysis of gene-disease association. (HuGE Navigator)
19774638 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19764044 MTHFR 677C->T and 1298A->C mutations is high in Turks and serum folate and homocysteine status are impaired by these mutations.
19764044 Observational study of gene-disease association. (HuGE Navigator)
19763346 an adolescent with a homozygote MTHFR 677CT mutation suffering a malignant stroke shortly after the start of oral contraceptives
19760026 there was no significant association between most SNPs in MTHFR, and the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women.
19760026 Observational study of gene-disease association. (HuGE Navigator)
19759169 *Importance of genetic variaiton of MTHFR inthe cmmplex relation between folate and breast cancer.
19759169 Observational study of gene-disease association. (HuGE Navigator)
19751749 Observational study of gene-disease association. (HuGE Navigator)
19751277 No asssociation between MTHFR single nucleotide polymorphisms and both, follicular lymphoma and diffuse, large B-Cell lymphoma was observed in a cohort of swedish patients.
19748501 Data show that MTHFR and TYMS genotypes influence TPMT activity, and that males and females demonstrate differential modulation of TPMT activity.
19748501 Observational study of gene-disease association. (HuGE Navigator)
19748043 MTHFR polymorphism and hyperhomocysteinemia were not risk factors in childhood arterial ischemic stroke or cerebral sinovenous thrombosis in the Intermountain West region
19748043 Observational study of gene-disease association. (HuGE Navigator)
19746410 Observational study of gene-disease association. (HuGE Navigator)
19744961 Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
19742390 Observational study of gene-disease association. (HuGE Navigator)
19737740 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19733705 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19733287 Observational study of gene-disease association. (HuGE Navigator)
19729796 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19729601 Observational study of gene-disease association. (HuGE Navigator)
19729099 There was some evidence that elevated tHcy was associated with RVO, but not homozygosity for the MTHFR C677T genotype.
19729099 Meta-analysis of gene-disease association. (HuGE Navigator)
19727233 No association between genetic polymorphism of MTHFR C677T and nonsyndromic cleft lip with or without palate was observed.
19727233 Observational study of gene-disease association. (HuGE Navigator)
19725133 Maternal 677T allele may be associated with an increased occurrence of congenital heart defects in children with Down syndrome.
19725133 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19720979 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19717029 Observational study of gene-disease association. (HuGE Navigator)
19716217 Observational study of gene-disease association. (HuGE Navigator)
19710606 Observational study of gene-disease association. (HuGE Navigator)
19707467 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19707223 No evidence for an association between the cSHMT genotype and breast cancer was observed. There was also no evidence of a gene-gene interaction between cSHMT and MTHFR.
19707223 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19706844 Meta-analysis of gene-disease association. (HuGE Navigator)
19706843 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19703820 Observational study of gene-disease association. (HuGE Navigator)
19700502 Meta-analysis of gene-disease association. (HuGE Navigator)
19694922 Hyperhomocysteinemia in patients homozygotes for the C677T mutation may interfere with erection mechanisms and thus be responsible for ED. In hyperhomocysteinemia associated with low levels of folates, the administration of PDE5 inhibitors may fail.
19694922 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19692168 Observational study of gene-disease association. (HuGE Navigator)
19683694 Observational study of gene-disease association. (HuGE Navigator)
19673907 The MTHFR 677TT genotype was associated with a reduced risk for migraine with aura, which only appeared for attacks fewer than six times/year
19673907 Observational study of gene-disease association. (HuGE Navigator)
19672255 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19669769 The MTHFR polymorphism C677T has a protective effect on colorectal cancer development. Both the C677T and A1298C variants are relevant and independent factors of patient outcome after 5FU-based treatment.
19669769 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19663673 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19661077 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19660787 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19660149 MTHFR gene is not associated with lean body, fat mass, trunk fat among 9-year-olds, and as this gene influences the biological availability of folate, this lack of association argues against a role for folate in determining body composition at age of 9.
19660149 Observational study of gene-disease association. (HuGE Navigator)
19657388 Observational study of gene-disease association. (HuGE Navigator)
19654594 An inverse relationship was observed between changes in tHcy and changes in the intake of beer in TT individuals but not in CC/CT individuals. Waist circumference and MTHFR genotype association seemed stronger in TT individuals than in CC/CT individuals
19654594 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19651439 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19650814 MTHFR polymorphism is associated with alcohol dependence.
19650814 Observational study of gene-disease association. (HuGE Navigator)
19649727 The polymorphism distribution of genes encoding MTR, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and MTHFD1 and MTHFR in patients with larynx cancer, was examined.
19649727 Observational study of gene-disease association. (HuGE Navigator)
19648163 Genotyping of folate polymorphisms might be useful in adult patients with acute lymphoblastic leukemia to optimize methotrexate therapy, reducing its associated toxicity with possible effects on survival.
19648163 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19637400 Men with alcohol use disorder had significantly higher ALDH2*1 and BDNF met allele frequencies compared to controls (p-values < 0.05) but no significant differences in genotype or allele frequencies were found for 5-HTTLPR or MTHFR (p-values > 0.3).
19637400 Observational study of gene-disease association. (HuGE Navigator)
19636001 Observational study of genotype prevalence, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19634497 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19633796 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19629345 Results did not show association between MTHFR A1298C and MTHFR C677T polymorphisms and presence, extension or severity of coronary artery disease.
19629345 Observational study of gene-disease association. (HuGE Navigator)
19625220 MTHFR 677T carriers had particularly elevated MCP-1 concentrations
19625220 Observational study of gene-disease association. (HuGE Navigator)
19625176 Observational study of gene-disease association. (HuGE Navigator)
19624857 Our study shows no major gene effect of either the MTHFR or GSTO-1 genes as a modifier of ischemic stroke volume.
19624857 Observational study of gene-disease association. (HuGE Navigator)
19619240 Determination of MTHFR C677T polymorphisms and homocysteine levels may be useful to identify patients with a high risk of suffering from migraine with aura.
19619240 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19618008 Observational study of gene-disease association. (HuGE Navigator)
19605746 incorporation of the number of alleles of MTHFR 1298A & 677C haplotype (0, 1 or 2) into the predictive model does not lead to an improvement in the number of classifiable patients in those with an intermediate probability of response to methotrexate.
19605746 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19604445 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19598005 No specific association of MTHFR gene mutation and hyperhomocysteinemia with retinopathy or neuropathy.
19598005 Observational study of gene-disease association. (HuGE Navigator)
19594372 Our study is the first to evaluate MTHFR C677T genotype frequency in a population of Middle Eastern patients residing in the United States. Among the patients, 47.6% were wild type, 40.5% were heterozygous, and 11.9% were homozygous for the C677T variant.
19594372 Observational study of gene-disease association. (HuGE Navigator)
19594369 Observational study of genotype prevalence. (HuGE Navigator)
19593234 Four single nucleotide polymorphisms of methylenetetrahydrofolate reductase(rs2066470, rs17037390, rs1801133) rs4846048) indicated significant interaction effects with various lifestyle factors on age at natural menopause
19593234 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19591822 We investigated the prevalence of single nucleotide polymorphisms in MTHFR associated with venous thromboembolism in 80 Sinhalese, 80 Sri Lankan Tamils and 80 Moors in the Sri Lankan population
19591822 Observational study of genotype prevalence. (HuGE Navigator)
19588544 The strongest result obtained by this study was for an additive effect between smoking status, slow NAT2 variants, MTR 2756*G and MTHFR 677*T alleles, in affecting bladder cancer risk
19588544 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19587357 Meta-analysis of gene-disease association. (HuGE Navigator)
19578796 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19578646 RA remission rate in carriers of the MTHFR 677T and 1298C alleles was more frequently observed, it does not seem that 677C>T and 1298A>C MTHFR polymorphisms have a major influence on treatment outcome in Rheumatoid arthritis treated with sulfasalazine.
19577428 MTHFR 677TT carriers with low folate and vitamin B12 intakes had the lowest survival rate in cases of gastric cancer.
19577428 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19565133 The MTHFR polymorphism did not show any association with the extension and/or severity of the coronary artery disease and no direct association with hyperhomocysteinemia or increased mean plasma concentrations of Hcy.
19565133 Observational study of gene-disease association. (HuGE Navigator)
19564051 A significant difference was observed in the plasma homocysteine levels among the patient with schizophrenia. And elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia
19564051 Observational study of gene-disease association. (HuGE Navigator)
19560472 Observational study of gene-disease association. (HuGE Navigator)
19559392 Observational study of gene-disease association. (HuGE Navigator)
19557016 MTHFR genetic polymorphisms and dietary intake of folate may modify susceptibility to breast cancer.
19557016 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19538716 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19537890 Observational study of genotype prevalence. (HuGE Navigator)
19536847 DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia
19536847 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19533869 The frequency of TT homozygote of MTHFR was higher in Alzheimer patients(AD) than controls. Serum levels of polyglutamyl folate was lower and homocystein was higher indicating bioavailabiility of folate may be impaired in AD.
19533869 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19533788 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19527514 Observational study of gene-disease association. (HuGE Navigator)
19525478 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19521764 the prevalence of MTHFR C677T and A1298C polymorphisms by analyzing genomic DNA in 30 cobalamin-deficient patients
19521764 Observational study of gene-disease association. (HuGE Navigator)
19520684 The TT genotype of C677T and the CC genotype of A1298C may act as risk factors for end-stage renal disease.
19520684 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19520681 Observational study of gene-disease association. (HuGE Navigator)
19520069 Observational study of gene-disease association. (HuGE Navigator)
19515015 Observational study of gene-disease association. (HuGE Navigator)
19514945 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19506726 Meta-analysis of gene-disease association. (HuGE Navigator)
19493349 Observational study of gene-disease association. (HuGE Navigator)
19492240 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19491810 Observational study of gene-disease association. (HuGE Navigator)
19487547 The data suggested that the 677C -->T polymorphism in MTHFR contributes significantly to the risk of colorectal cancer susceptibility in the Mexican population.
19487547 Observational study of gene-disease association. (HuGE Navigator)
19484352 MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism is marginally associated with psoriasis.
19484352 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19479237 Observational study of gene-disease association. (HuGE Navigator)
19477879 hyper-methylation in testis DNA from non-obstructive azoospermia patients is specific and not due a general methylation defect, and suggest that epigenetic silencing of MTHFR could play a role in azoospermic infertility.
19474452 Observational study of genetic testing. (HuGE Navigator)
19466593 The C677T mutation of methylenetetrahydrofolate reductase was not different in hemodialysis patients and healthy controls, and there were no differences between patients regarding cardiovascular events or cardiovascular risk factors.
19465420 MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer are reported.
19463111 Activating effect of PLAA1/A2 polymorphism of GPIIIa gene and 677T/T polymorphism of MTHFR gene on morphofunctional state of platelets is proved.
19461557 Observational study of gene-disease association. (HuGE Navigator)
19455642 thought to explain or at least play a role in the development of autism among a relatively small proportion of affected children
19450180 MTHFR SNPs may play an important role in providing rational, effective and safe tailored treatment to patients with cancer and inflammatory disorders requiring 5FU and MTX-based therapy
19448163 The TT genotype of the C677T polymorphism in the methylentetrahydrofolate reductase as a risk factor in thrombotic microangiopathies: results from a pilot study.
19447376 MTHFR C677T and A1298C variants are not associated with the risk of the pathogenesis of non-syndromic cleft lip/palate in northern Venezuela.
19442614 The results suggest that MTHFR at 1p36, individually or in different combinations, contribute to osteoporosis susceptibility in Chinese.
19437140 These data have confirmed the association between serum homocysteine levels and MTHFR C677T genotype reported in other populations.
19432826 Observational study of gene-disease association. (HuGE Navigator)
19430483 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
19427504 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19427093 The C677T polymorphism of MTHFR gene is not associated with polycystic ovary syndrome in a Korean population, suggesting that the C677T polymorphism in MTHFR may have different influences in various ethnic groups and diseases.
19427093 Observational study of gene-disease association. (HuGE Navigator)
19421414 no evidence found of association between visual failure in Leber hereditary optic neuropathy (LHON) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms or the MTHFR haplotype
19421414 Observational study of gene-disease association. (HuGE Navigator)
19420105 Observational study of gene-disease association. (HuGE Navigator)
19419265 MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population.
19419265 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19403988 MTHFR 677 TT homozygotes are more likely to develop atherosclerosis than heterozygotes or CC homozygotes, if they smoke
19403988 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19398669 Genetic polymorphism 677 C>T on MTHFR affects vascular 5-MTHF but not homocysteine
19398669 Observational study of gene-disease association. (HuGE Navigator)
19395327 Observational study of gene-disease association. (HuGE Navigator)
19394322 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19391036 Study suggests that A1298C gene, but not C677T polymorphism is associated with MTX-related toxicity.
19391036 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19389261 MTHFR polymorphisms and dietary intake of folate, vitamin B6, and vitamin B12 had no association with breast cancer risk.
19389261 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19384296 The C/C genotype of the MTHFR C677T polymorphism was protective against grade 3-4 toxicity after 5-FU treatment of colorectal cancer.
19384296 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19384265 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19376104 Presence of the 894T allele aggravated renal damage and increased the incidence of cardiovascular disease in Tunisian chronic renal disease patients.
19376104 Observational study of gene-disease association. (HuGE Navigator)
19374152 mutations in MTHFR C677T/A1298C were found in patients with sudden sensorineural hearing loss and cardiovascular thrombotic disease
19374152 Observational study of gene-disease association. (HuGE Navigator)
19373490 MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T were significant combinational contributors to thrombotic stroke.
19372453 Observational study of gene-disease association. (HuGE Navigator)
19372095 statistical significance was observed for the association of MTHFR CT and eNOS TT gene variants in children with arterial ischemic stroke: results suggest that this genotype combination represents a risk factor of 7.2 (P = .017) for stroke
19372095 Observational study of gene-disease association. (HuGE Navigator)
19367581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19356065 Our study lends further support to the hypothesis that the MTHFR polymorphism (677C>T or 1298A>C) is involved in susceptibility to cervical dysplasia.
19353312 The increased prevalence rate and coexistence of both factor V and methylenetetrahydrofolate reductase found in this group of patients suggest that these mutations might increase the risk of arterial thrombosis.
19353312 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19353223 Observational study of gene-disease association. (HuGE Navigator)
19349859 Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran.
19349859 Observational study of gene-disease association. (HuGE Navigator)
19349296 MTHFR 677C>T/1298A>G and MTR 2756A>G polymorphism distribution in both recipients (R) and donors (D) showed no significant difference between matches with loss of graft function and those with long-term graft survival
19349296 Observational study of gene-disease association. (HuGE Navigator)
19346876 The homozygous TT and heterozygous CT genotypes were associated with a significantly higher frequency of Wilm's tumor than CC genotype
19346876 Observational study of gene-disease association. (HuGE Navigator)
19342053 Our findings suggest that TT677 MTHFR genotype promotes plasma homocysteine increase which in turn may favour intima-media thickening in patients with cognitive impairment.
19342053 Observational study of gene-disease association. (HuGE Navigator)
19340000 However, no association between MTHFR C677T genotype and cumulative event-free survival was observed in our study population
19340000 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19339270 Observational study of gene-disease association. (HuGE Navigator)
19338708 neither maternal nor infant MTHFR genotype alone was associated with newborn size and that these genotypes did not modify the effects of folate intake or lead on newborn size.
19338708 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19336565 MTHFR 677T allele was associated with breast cancer.
19336565 Observational study of gene-disease association. (HuGE Navigator)
19336437 Observational study of gene-disease association. (HuGE Navigator)
19336370 Observational study of gene-disease association. (HuGE Navigator)
19336355 Observational study of gene-disease association. (HuGE Navigator)
19333678 Observational study of gene-disease association. (HuGE Navigator)
19332728 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19332210 We found significant associations between certain candidate genetic polymorphisms and baseline plasma levels of FGB, homocysteine, and ICAM-1 in women from various race/ethnic groups.
19332210 Observational study of gene-disease association. (HuGE Navigator)
19330466 Methylentetrahydrofolate reductase G677T allele is significantly associated with myocardial infarction.
19330466 Observational study of gene-disease association. (HuGE Navigator)
19328558 Observational study of gene-disease association. (HuGE Navigator)
19326430 MTHFR C677T polymorphism is associated with colorectal cancer.
19326430 Observational study of gene-disease association. (HuGE Navigator)
19326344 Observational study of gene-disease association. (HuGE Navigator)
19324355 Observational study of gene-disease association. (HuGE Navigator)
19307503 MTHFR wild-type or heterozygous mutations are associated with non-small-cell lung cancer.
19307503 Clinical trial of gene-disease association. (HuGE Navigator)
19303062 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
19299182 Observational study of gene-disease association. (HuGE Navigator)
19298544 MTHFR TT genotype was associated with migraine with aura.
19298544 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19288150 The carriers of the variant genotype (MTHFR 677TT) had twofold increase in gastric cancer risk compared to those with the MTHFR 677CC genotype
19288150 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19283524 Observational study of gene-disease association. (HuGE Navigator)
19283448 correlation between the A1298C polymorphism and plasma folate concentration
19283448 Observational study of gene-disease association. (HuGE Navigator)
19282368 Observational study of gene-disease association. (HuGE Navigator)
19280995 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19272686 The mutant TT genotype at nucleotide 677 of the gene regulating MTHFR activity may increase the mortality risk in patients with ESRD.
19272686 Observational study of gene-disease association. (HuGE Navigator)
19267885 The results of the MTHFR gene analysis showed a normal distribution of the C677T polymorphism in children with Autism spectrum disorders.
19267885 Observational study of gene-disease association. (HuGE Navigator)
19267198 Observational study of gene-disease association. (HuGE Navigator)
19267073 Hyperhomocysteinemia and MTHFR with T allele might be the risk factors for type 2 diabetes mellitus with coronary heart disease in northern Chinese Han population.
19267073 Observational study of gene-disease association. (HuGE Navigator)
19263808 relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase (MTHFR) gene and methionine synthase (MS) gene
19263808 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19263529 Observational study of gene-disease association. (HuGE Navigator)
19263510 Observational study of gene-disease association. (HuGE Navigator)
19256756 Reduced risk of colorectal cancer recurrence rate was observed in patients with MTHFR polymorphism in Iranian population.
19256756 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19254790 In a population with a high prevalence of the mutated T allele, maternal MTRR A66G, but not MTHFR, polymorphisms are associated with Down syndrome.
19254790 Observational study of gene-disease association. (HuGE Navigator)
19254215 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19253755 The prevalence of the mutant alleles among patients with deep vein thrombosis in Uzbekistan was revealed: for factor V Leiden--12,9%, prothrombin--4%, MTHFR--47,8%.
19253755 Observational study of gene-disease association. (HuGE Navigator)
19251870 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19251185 Observational study of gene-disease association. (HuGE Navigator)
19248194 Observational study of gene-disease association. (HuGE Navigator)
19247692 Observational study of gene-disease association. (HuGE Navigator)
19246914 Our data suggest a critical role for interleukin 8 and MTHFR interactions in the development of Alzheimer disease
19246914 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19245802 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19240236 Overall, we found no evidence that common polymorphisms of the MTHFR and MTR genes are associated with promoter methylation of E-cadherin, p16, and RAR-beta2 genes in breast cancer.
19240236 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19238444 HuGE review of gene-disease association and gene-environment interaction. (HuGE Navigator)
19235787 findings do not support a major role for COMT or MTHFR alone, however, an epigenetic interaction of COMT Val158Met and MTHFR C677T polymorphisms may contribute to putamen volumes differences between depressed and nondepressed subjects.
19235787 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19232336 High serum concentrations of homocysteine, cholesterol and uric acid, and low concentrations of estradiol and vitamin B, as well as the MTHFR 1298A-->C mutation are simultaneously associated to Alzheimer's type dementia.
19232336 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19225709 The geometric dimensions of the proximal femur in perimenopausal women are not associated with the MTHFR polymorphism.
19225709 Observational study of gene-disease association. (HuGE Navigator)
19225123 From a population perspective, the MTHFR 677C-->T variant does not warrant modifications to the current RDA for dietary folate.
19223177 the C677T of the MTHFR gene is a low-penetrance susceptibility gene for prostate cancer, and might provide protective effects against prostate cancer risk.
19223177 Meta-analysis of gene-disease association. (HuGE Navigator)
19219640 Our finding indicate the prevalence of factor V Leiden, prothrombin G20210A and MTHFR C677T in G6PD deficiency is not statistically different compared to normal subjects and is not associated with these thrombophilic mutations in Western Iran.
19219640 Observational study of gene-disease association. (HuGE Navigator)
19219535 Genetic variants of PON1 55/192 and MTHFR were associated with coronary artery disease
19219535 Observational study of gene-disease association. (HuGE Navigator)
19211833 in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma homocysteine
19211833 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19211287 Observational study of gene-disease association. (HuGE Navigator)
19210273 Observational study of gene-disease association. (HuGE Navigator)
19208607 Meta-analysis of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19206005 Observational study of gene-disease association. (HuGE Navigator)
19203896 The MTHFR polymorphism C677T can affect the treatment and outcome in stage III colon cancer.
19203896 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19193985 presence of the T allele in MTHFR is a risk factor for ischemic stroke in Polish subjects
19193985 Observational study of gene-disease association. (HuGE Navigator)
19193698 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19186536 MTHFR gene is a marker for visceropathies in workers exposed to dust.
19180309 MTHFR polymorphisms 677TT and 1298AC are a risk factor for spontaneous abortion in a Mexican population regardless of vitamin B intake.
19180309 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19178944 Mutations in the MTHFR gene decrease the onset risk of acute lymphoblastic leukemia, but not of recurrence-free survival.
19178944 Observational study of gene-disease association. (HuGE Navigator)
19178787 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19177501 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19172696 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19169973 Simultaneous carrier-state of MTHFR, IL-6 and ICAM1 genes increased the risk of Coronary artery disease.
19169973 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19169966 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19169497 No correlation was observed between the MTHFR gene polymorphism 677 and chromosomal aneuploidy in the Turner Syndrome patients.
19169497 Observational study of gene-disease association. (HuGE Navigator)
19168828 We report 2 cases with schizencephaly and thrombophilia caused by mutations of the methyltetrahydrofolate reductase and the factor V Leiden genes.
19167867 These results suggested, the CC genotype, not TT genotype of MTHFR C677T was the risk factor for livedoid vasculopathy in Taiwanese population.
19167867 Observational study of gene-disease association. (HuGE Navigator)
19166826 Observational study of gene-disease association. (HuGE Navigator)
19161160 Observational study of gene-disease association. (HuGE Navigator)
19159907 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19157768 Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis.
19157768 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19156174 The Kaplan-Meier survival analysis revealed that MTHFR compound heterozygotes for the two SNPs developed CRC 10 years later compared with those carrying only wild-type alleles.
19156174 Observational study of gene-disease association. (HuGE Navigator)
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19150531 Factor V G1691A heterozygous mutation was detected in two children, and methylene tetrahydrofolate reductase C677T homozygous mutation was detected in one child with PTE.
19148342 MTHFR single nucleotide polymorphisms were not associated with increased Common carotid intima-media thickness.
19148342 Observational study of gene-disease association. (HuGE Navigator)
19144510 the potential pharmacogenetic role of C677T and A1298C polymorphisms as genetic determinants of the efficacy and toxicity of antifolate and fluoropyrimidine-based therapy and their interaction with environmental factors remain quite uncertain
19142139 There was no significant difference in frequency of MTHFR C677T gene mutation between glaucoma groups.
19142139 Observational study of gene-disease association. (HuGE Navigator)
19137091 Observational study of genetic testing. (HuGE Navigator)
19133039 Observational study of genotype prevalence. (HuGE Navigator)
19131662 Meta-analysis of gene-disease association. (HuGE Navigator)
19127083 Observational study of gene-disease association. (HuGE Navigator)
19125845 Observational study of gene-disease association. (HuGE Navigator)
19124506 Observational study of gene-disease association. (HuGE Navigator)
19123462 methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation resulting in site-specific cancer risk modification
19123042 Observational study of gene-disease association. (HuGE Navigator)
19121630 The current results also indicate that the folic acid concentration is much more influential than the MTHFR C677T polymorphisms in the processes of genetic damage and cell death.
19112534 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19111530 Parental hyperhomocysteinemia, paternal age, paternal C677T MTHFR polymorphism and DNA damage are risk factors for recurrent pregnancy loss.
19111530 maternal & paternal hyperhomocysteinemia, paternal MTHFR 677T allele were associated with 4.48, 6.92 and 2.30 folds risk for recurrent pregnancy loss.
19111530 Observational study of gene-disease association. (HuGE Navigator)
19110485 Observational study of gene-disease association. (HuGE Navigator)
19103110 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19093229 Observational study of gene-disease association. (HuGE Navigator)
19091662 Observational study of gene-disease association. (HuGE Navigator)
19083485 Observational study of gene-disease association. (HuGE Navigator)
19082889 MTHFR 677T allele associated with risk of DNA methylation in gastric mucosa in the long-term outcome of H. pylori infection
19082889 Observational study of gene-disease association. (HuGE Navigator)
19081115 synergistic role of ACE (DD)*MTHFR (CT) interaction, showing a positive association in total migraine with aura patients as well as female migraine patients with aura when compared with healthy controls
19081115 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19079989 Observational study of gene-disease association. (HuGE Navigator)
19075497 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19074885 Observational study of gene-disease association. (HuGE Navigator)
19074750 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19072566 Observational study of genotype prevalence. (HuGE Navigator)
19071013 Observational study of gene-disease association. (HuGE Navigator)
19070828 Observational study of gene-disease association. (HuGE Navigator)
19068258 cerebral infarctions in infants associated with the MTHFR mutation
19066200 No evidence was found for association of MTHFR C677T polymorphism with polycystic ovary syndrome.
19066200 Meta-analysis of gene-disease association. (HuGE Navigator)
19065440 The present study failed to reveal any association between MTHFR polymorphism and risk of acute myeloid leukemia in Down syndrome (DS) children. The data also indicate that MTHFR polymorphisms are not associated with risk of being a DS child.
19065440 Observational study of gene-disease association. (HuGE Navigator)
19064578 Observational study of gene-disease association. (HuGE Navigator)
19064572 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19063701 Increased homocysteine levels but not MTHFR 677C-->T genotype, are associated with subclinical atherosclerosis and the presence of plaques
19063701 Observational study of gene-disease association. (HuGE Navigator)
19062539 Observational study of genotype prevalence. (HuGE Navigator)
19058336 Low consumption of green vegetables and fresh fruits, alcohol drinking, and unsafe water (shallow well, or river) and polymorphisms in MTHFR and CYP4502E1 genes are important risk factors for esophageal cancer.
19058336 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19056652 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19052924 gene polymorphism is associated with recurrent pregnancy losses
19049547 Observational study of gene-disease association. (HuGE Navigator)
19048631 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19040733 there is genetic selection in our population for the T allele of the MTHFR - 677C>T polymorphism, whose origin could be an increase in fetal viability during the early stages of embryonic development
19039150 Coronary artery disease in north Indian patients is not associated with the C677T transition in the methylenetetrahydrofolate reductase gene.
19037576 MTHFR gene variation was only weakly related to one of the bone outcome measures.
19035314 The MTHFR 1298A>C and the MTRR 66A>G genotypes were associated with an increased risk of hepatocellular carcinoma in this Korean population.
19034339 The synergistic effect of MTHFR 1298AC and 677CT and its abolishment by MS 2756AA or AG emphasizes that the interaction of genes, rather than the polymorphism in any single one, determines risk susceptibility to pediatric acute lymphoblastic leukemia.
19034339 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19026285 MTHFR C677T polymorphism is not associated with an increased risk of Down syndrome in the north Indian population
19026285 Observational study of gene-disease association. (HuGE Navigator)
19020309 MTHFR and TS gene variants are associated with decreased acute lymphoblastic leukemia risk
19020309 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19019492 Of the studied polymorphisms, only MTHFR 677C>T was associated with homocysteine concentration. No significant relationship was observed for any of the polymorphisms with cognitive performance or severity of cerebral white matter lesions.
19019492 Observational study of gene-disease association. (HuGE Navigator)
19019335 Observational study of gene-disease association. (HuGE Navigator)
19018779 Observational study of gene-disease association. (HuGE Navigator)
19016697 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19013496 This study suggested that hypertension combined with a genetic vascular risk factor may significantly increase risk for cognitive impairment.
19013496 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19008959 Meta-analysis of gene-disease association. (HuGE Navigator)
19005482 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19004141 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19000982 Mesenteric venous thrombosis with bowel infarction and hyperhomocysteinemia due to homozygous methylenetetrahydrofolate reductase C677T genotype (Case Report).
18996879 These results show an association between the C677T MTHFR variant and different folate intakes on risk of colorectal neoplasm.
18996879 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18992148 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18990369 Mutations of MTHFR and TSER are not likely significant risk factors of idiopathic recurrent spontaneous abortion in Korean women.