MTF1
Metal regulatory transcription factor 1
Protein Summary
Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
- ENST00000373036
- ENSP00000362127
- ENSG00000188786
- ZRF
- MTF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
transcription factor perturbation | 0.94 | ||
virus perturbation | 0.9 | ||
disease perturbation | 0.87 | ||
histone modification site profile | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 139.24 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 139.24 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0