Property Summary

NCBI Gene PubMed Count 21
PubMed Score 29.17
PubTator Score 15.79

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (22)

Disease log2 FC p
malignant mesothelioma -1.600 2.2e-06
cutaneous lupus erythematosus -1.300 7.9e-03
osteosarcoma 1.655 4.1e-05
group 3 medulloblastoma -2.200 5.7e-05
cystic fibrosis 1.052 2.7e-04
atypical teratoid/rhabdoid tumor -1.700 2.4e-05
medulloblastoma, large-cell -2.200 5.6e-04
acute quadriplegic myopathy 1.527 8.4e-09
primary pancreatic ductal adenocarcinoma -1.741 4.8e-03
non-small cell lung cancer -1.521 2.9e-11
intraductal papillary-mucinous adenoma (... -1.900 1.0e-02
intraductal papillary-mucinous carcinoma... -2.200 2.8e-02
intraductal papillary-mucinous neoplasm ... -3.400 4.3e-03
lung cancer -3.200 7.8e-07
colon cancer -2.100 1.2e-05
active Crohn's disease -1.097 3.1e-02
pancreatic cancer -1.800 6.9e-03
Endometriosis -2.368 2.4e-02
lung carcinoma 1.200 1.3e-05
Breast cancer -1.100 3.9e-05
ulcerative colitis -2.300 1.2e-07
ovarian cancer 2.500 7.5e-07

Gene RIF (5)

PMID Text
24662736 MT1H was down-regulated in renal cell carcinogenesis.
20551211 Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
15747776 Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity.
12539042 Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection
12081484 S-nitrosothiols react preferentially with zinc thiolate clusters through transnitrosation.

AA Sequence

MDPNCSCEAGGSCACAGSCKCKKCKCTSCKKSCCSCCPLGCAKCAQGCICKGASEKCSCCA               1 - 61
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Text Mined References (21)

PMID Year Title
24662736 2015 An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.
22780124 2013 Genome-wide association study of a quantitative disordered gambling trait.
20551211 2010 Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
16827180 2006 Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes.
15747776 2003 Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14668352 2004 The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.
12970870 2003 Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene.
12646258 2003 ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis.
12539042 2003 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12081484 2002 S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
11168427 2001 Metallothionein isogene transcription in red blood cell precursors from human cord blood.
11093034 2000 Metallothionein biosynthesis in human RBC precursors.
11053642 2000 In vivo gene expression profile analysis of metallothionein in renal cell carcinoma.
10774930 2000 Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes.
8619255 1996 Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney.
8119276 1994 Induction by zinc of specific metallothionein isoforms in human monocytes.
8049263 1994 Characterisation of six additional human metallothionein genes.
2286373 1990 Human metallothionein genes: structure of the functional locus at 16q13.
1425708 1992 Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform.