| Tbio | Metallothionein-1G |
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Comments
| Disease | Target Count |
|---|---|
| Esophageal Neoplasms | 67 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 3.4e-12 |
| acute quadriplegic myopathy | 1157 | 8.3e-09 |
| ulcerative colitis | 2087 | 5.5e-08 |
| malignant mesothelioma | 3163 | 2.5e-07 |
| osteosarcoma | 7933 | 1.1e-06 |
| lung cancer | 4473 | 3.9e-06 |
| atypical teratoid/rhabdoid tumor | 1095 | 1.0e-05 |
| colon cancer | 1475 | 1.8e-05 |
| group 3 medulloblastoma | 2254 | 5.7e-05 |
| lung adenocarcinoma | 2714 | 1.1e-04 |
| ovarian cancer | 8491 | 1.8e-04 |
| cystic fibrosis | 1670 | 2.9e-04 |
| medulloblastoma, large-cell | 6234 | 9.8e-04 |
| psoriasis | 6685 | 1.3e-03 |
| adrenocortical carcinoma | 1427 | 2.0e-03 |
| nephrosclerosis | 329 | 2.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 3.7e-03 |
| pancreatic cancer | 2300 | 9.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 9.5e-03 |
| primary pancreatic ductal adenocarcinoma | 1271 | 1.2e-02 |
| Endometriosis | 535 | 1.4e-02 |
| active Crohn's disease | 918 | 2.6e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| nephrosclerosis | -1.130 | 2.3e-03 |
| malignant mesothelioma | -1.700 | 2.5e-07 |
| psoriasis | -1.100 | 1.3e-03 |
| osteosarcoma | 1.923 | 1.1e-06 |
| group 3 medulloblastoma | -2.300 | 5.7e-05 |
| cystic fibrosis | 1.128 | 2.9e-04 |
| atypical teratoid/rhabdoid tumor | -1.700 | 1.0e-05 |
| medulloblastoma, large-cell | -2.000 | 9.8e-04 |
| acute quadriplegic myopathy | 1.263 | 8.3e-09 |
| adrenocortical carcinoma | -1.186 | 2.0e-03 |
| primary pancreatic ductal adenocarcinoma | -2.075 | 1.2e-02 |
| non-small cell lung cancer | -1.741 | 3.4e-12 |
| intraductal papillary-mucinous adenoma (... | -2.200 | 9.5e-03 |
| intraductal papillary-mucinous carcinoma... | -2.600 | 2.7e-02 |
| intraductal papillary-mucinous neoplasm ... | -3.800 | 3.7e-03 |
| lung cancer | -3.100 | 3.9e-06 |
| colon cancer | -2.100 | 1.8e-05 |
| active Crohn's disease | -1.249 | 2.6e-02 |
| pancreatic cancer | -2.000 | 9.2e-03 |
| lung adenocarcinoma | -1.300 | 1.1e-04 |
| Endometriosis | -2.839 | 1.4e-02 |
| ulcerative colitis | -2.500 | 5.5e-08 |
| ovarian cancer | 1.800 | 1.8e-04 |
| PMID | Text | |
|---|---|---|
| 25072246 | PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation | |
| 24782625 | MT1M and MT1G promoter methylation may be used as serum biomarkers for noninvasive detection of hepatocellular carcinoma. | |
| 24662736 | MT1G was down-regulated in renal cell carcinogenesis. | |
| 24634414 | Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. | |
| 24098937 | Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. | |
| 23902976 | GPR56, MT1G, and RASSF1 might be the potential methylation markers associated with acquired multidrug resistance of lung adenocarcinoma. | |
| 20812968 | MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts. | |
| 20551211 | Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia. | |
| 20032811 | Results describe MT1G promoter hypermethylation in hepatoblastoma and demonstrate that aberrant methylation is a frequent event in this malignancy. | |
| 19639168 | MT1G acts as a tumor suppressor gene in hepatocellular carcinoma | |
| 19506903 | p16INK4A, DAPK1, PTEN and MT1G genes were not frequently methylated in the stage I non-small cell lung cancer in China. | |
| 19491193 | Promoter methylation and differential gene expression of five markers: COL1A2, NPM2, HSPB6, DDIT4L and MT1G were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, respectively. | |
| 19137073 | Using a panel of four genes (AHRR, p16INK4a, MT1G, and CLDN3) resulted in sensitivity and specificity of 50% and 68%, respectively and may have utility for early detection of esophageal squamous dysplasia and early ESCC. | |
| 18639284 | MT1G is hypermethylated in renal cell carcinoma. | |
| 15747776 | Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Heavy metal binding activity. | |
| 15735762 | Induction of the hMT1G promoter by VEGF and heavy metals occurs through the utilization of different transcription factors. | |
| 12640681 | Loss of metallothionein 1G function due to hypermethylation of its promoter leads to athogenesis of papillary thyroid carcinoma | |
| 12539042 | Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection |
| PMID | Year | Title | |
|---|---|---|---|
| 25072246 | 2014 | A PU.1 suppressive target gene, metallothionein 1G, inhibits retinoic acid-induced NB4 cell differentiation. | |
| 24782625 | 2014 | MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma. | |
| 24662736 | 2015 | An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis. | |
| 24634414 | 2014 | Metallothionein 1G and zinc sensitize human colorectal cancer cells to chemotherapy. | |
| 24098937 | 2013 | Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway. | |
| 23902976 | 2013 | Promoter methylation profiles between human lung adenocarcinoma multidrug resistant A549/cisplatin (A549/DDP) cells and its progenitor A549 cells. | |
| 22780124 | 2013 | Genome-wide association study of a quantitative disordered gambling trait. | |
| 20812968 | 2010 | Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro. | |
| 20551211 | 2010 | Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia. | |
| 20032811 | 2010 | MT1G hypermethylation: a potential prognostic marker for hepatoblastoma. | |
| 19639168 | 2009 | Detection of metallothionein 1G as a methylated tumor suppressor gene in human hepatocellular carcinoma using a novel method of double combination array analysis. | |
| 19506903 | 2009 | RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. | |
| 19491193 | 2009 | Genome-wide screen of promoter methylation identifies novel markers in melanoma. | |
| 19330122 | 2003 | Low-Dose Cadmium Exposure Reduces Human Prostate Cell Transformation in Culture and Up-Regulates Metallothionein and MT-1G mRNA. | |
| 19137073 | 2008 | Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma. | |
| 18639284 | 2008 | Identification of novel epigenetic markers for clear cell renal cell carcinoma. | |
| 18332874 | 2008 | Metallothionein 1G acts as an oncosupressor in papillary thyroid carcinoma. | |
| 16827180 | 2006 | Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes. | |
| 15862967 | 2005 | Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. | |
| 15747776 | 2003 | Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. | |
| 15735762 | 2005 | Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 12970870 | 2003 | Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. | |
| 12646258 | 2003 | ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. | |
| 12640681 | 2003 | Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma. | |
| 12539042 | 2003 | HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11168427 | 2001 | Metallothionein isogene transcription in red blood cell precursors from human cord blood. | |
| 8119276 | 1994 | Induction by zinc of specific metallothionein isoforms in human monocytes. | |
| 7559655 | 1995 | Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies. | |
| 6089206 | 1984 | Human metallothionein genes are clustered on chromosome 16. | |
| 3403543 | 1988 | Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals. | |
| 3023827 | 1986 | Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids. | |
| 2444457 | 1987 | Structure and expression of the human metallothionein genes. | |
| 2286373 | 1990 | Human metallothionein genes: structure of the functional locus at 16q13. |
