| Tbio | Metallothionein-1E |
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 7.1e-14 |
| malignant mesothelioma | 3232 | 4.5e-10 |
| acute quadriplegic myopathy | 1158 | 3.2e-09 |
| ulcerative colitis | 1819 | 1.3e-07 |
| lung adenocarcinoma | 2716 | 4.0e-07 |
| Breast cancer | 3578 | 1.4e-06 |
| ovarian cancer | 8520 | 7.3e-06 |
| colon cancer | 1478 | 8.9e-06 |
| pancreatic cancer | 2398 | 2.0e-05 |
| lung cancer | 4740 | 2.0e-05 |
| group 3 medulloblastoma | 4104 | 2.1e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.0e-05 |
| medulloblastoma, large-cell | 6241 | 4.5e-05 |
| breast carcinoma | 1638 | 9.0e-05 |
| osteosarcoma | 7950 | 5.8e-03 |
| adrenocortical carcinoma | 1428 | 7.2e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.9e-03 |
| Down syndrome | 499 | 1.1e-02 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.8e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.3e-02 |
| facioscapulohumeral dystrophy | 288 | 3.0e-02 |
| Endometriosis | 540 | 3.1e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 2.238 | 3.2e-09 |
| adrenocortical carcinoma | -1.122 | 7.2e-03 |
| atypical teratoid / rhabdoid tumor | -2.400 | 3.0e-05 |
| Breast cancer | -1.400 | 1.4e-06 |
| breast carcinoma | -1.100 | 9.0e-05 |
| colon cancer | -1.800 | 8.9e-06 |
| Down syndrome | 1.300 | 1.1e-02 |
| Endometriosis | -2.148 | 3.1e-02 |
| facioscapulohumeral dystrophy | -1.900 | 3.0e-02 |
| group 3 medulloblastoma | -2.700 | 2.1e-05 |
| intraductal papillary-mucinous adenoma (... | -1.300 | 2.3e-02 |
| intraductal papillary-mucinous carcinoma... | -1.800 | 3.2e-02 |
| intraductal papillary-mucinous neoplasm ... | -2.700 | 7.9e-03 |
| lung adenocarcinoma | -1.800 | 4.0e-07 |
| lung cancer | -2.600 | 2.0e-05 |
| malignant mesothelioma | -6.700 | 4.5e-10 |
| medulloblastoma, large-cell | -3.200 | 4.5e-05 |
| non-small cell lung cancer | -1.935 | 7.1e-14 |
| osteosarcoma | 1.280 | 5.8e-03 |
| ovarian cancer | 1.800 | 7.3e-06 |
| pancreatic cancer | -1.100 | 2.0e-05 |
| primary pancreatic ductal adenocarcinoma | -1.573 | 1.8e-02 |
| ulcerative colitis | -2.000 | 1.3e-07 |
