Property Summary

NCBI Gene PubMed Count 65
PubMed Score 95.87
PubTator Score 41.18

Knowledge Summary


No data available


Gene RIF (41)

26583802 Zn(ii) and Cd(ii) metalation of the human MT1a takes place through two distinct pathways.
26475450 We report on the competitive zinc metalation of apo-carbonic anhydrase [CA; metal-free CA (apo-CA)] in the presence of apo-metallothionein 1A domain fragments to identify domain specific determinants of zinc binding and zinc donation
26401817 The Zinc and Cadmium exchange kinetics between human MT1A and carbonic anhydrase were examined using time-dependent electrospray ionization mass spectrometry.
26167879 Modeling of the reactions showed that at both physiological (7.4) and acidic (5.8) pHs, zinc binding and cadmium exchanges occur essentially randomly between two MT1A fragments.
25208334 Data indicate the calculated equilibrium zinc binding constants of each of the 7 zinc metallothionein 1A species ranged from a high of (log(KF)) 12.5 to a low of 11.8.
24140052 The metal-free, apo-alpha-MT also adopts a folded structure in the presence of the As(3+) even though there is no As(3+) bound.
23947958 Low MT1A expression is associateed with lung carcinogenesis.
23763497 Increased metallothionein expression reflects steroid resistance in renal allograft recipients.
23506369 During the titration with Zn(2+), the electrospray ionization mass spectrometry data show that several metalated species coexist until the fully saturated proteins are formed.
23501100 MT-1A is epigenetically regulated by PU.1 during monocytic differentiation.
23429061 Polymorphisms in the MT1A gene may influence excretion of urine uric acid and N-acetyl-beta-D-glucosamine in chronic lead-exposed workers.
23042264 A positive correlation between MT and Ki-67 expression was observed for all the studied cases but was even stronger in the metatypic subtype of basal cell carcinoma.
22995156 MT1A rs11076161 was associated with B-Cd concentrations and Cd-induced kidney toxicity at high exposure levels.
22090273 Possible role of MT as a marker of cell stress and homeostasis restoration in Graves'disease.
21798283 Variations in the ability of LAT1/DMT1/MTF1/MT1a to process and transport Hg may not play a significant role in the etiology of autism.
21103883 The expression of metallothioneins MT1A and MT1X was significantly downregulated during differentiation of Caco-2 cells treated with high levels of zinc.
20812968 MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts.
20634891 Observational study of gene-disease association. (HuGE Navigator)
20038220 Data show that MT-I + II and megalin are significantly altered in CNS lymphoma relative to controls.
19962295 Observational study of gene-disease association. (HuGE Navigator)
19529947 HIF-1alpha expression qualified as an independent prognostic and characterised an aggressive cancer phenotype associated with an increased expression of MT.
19515364 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19359654 MT-IA mRNA expression in HPBLs may be used as a biomarker for renal dysfunction in occupational cadmium exposure.
18601746 Lupus nephritis is associated with significant alterations in renal MT-I+II expression. Important prognostic information can be deduced from the renal MT-I+II expression profile in systemic lupus erythematosus patients with nephritis.
18533113 This study provides the necessary data establishing unambiguously the noncooperative nature of cadmium binding to both isolated domains and the combined beta-domains (beta-rhMT) of human MT-1a.
18429853 Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of MT1A.
18349110 Observational study of gene-disease association. (HuGE Navigator)
18316168 the interleukin-6 and metallothionein 1a genes act in a concerted manner to control zinc-regulated gene expression
18249147 the association of the +647 A/C MT1A polymorphism with diabetes mellitus 2 and cardiovascular complications
18249147 Observational study of gene-disease association. (HuGE Navigator)
18208603 The goals of this study were to define the expression of the isoforms of MT 1, 2, 3 at both mRNA and protein levels, in normal prostate, benign prostatic hyperplasia (BPH) and malignant PC-3 cells.
17388808 The partially metallated and metal-free metallothionein-1a species are stable intermediates and thus may have a potential role in the currently undefined function of metallothionein.
17373731 One biomarker which has recently shown to be expressed in various human tumors but still less reported in carcinoma is metallothionein.
17111383 The findings define a pathway for cellular metal acquisition. The results suggest a function of MT in intercellular communication.
17008879 analysis of glial fibrillary acidic protein, metallothionein, and MHC II expression in human, rat and mouse cells
16955215 +647 MT1a genetic polymorphism may be essential for longevity in women.
16107899 MT-II mRNA expression may be involved in cell proliferation in the livers of patients with chronic HCV infection.
16087360 The overexpression of human MT1A gene dynamically affected cell viability, and the effect was influenced by zinc and cadmium ions.
15812196 metallothionein measured in renal specimens from cadaver kidneys was restricted to tubular cells with no differences between controls and patients with death due to chronic diseases
12970870 Metallothionein, potential interaction partner for ECRG2, might be involved in regulation of cell proliferation and apoptosis and in various physiological processes.
12539042 Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection

AA Sequence


Text Mined References (66)

PMID Year Title
26583802 2016 Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion.
26475450 2015 Putting the pieces into place: Properties of intact zinc metallothionein 1A determined from interaction of its isolated domains with carbonic anhydrase.
26401817 2015 Kinetics of Zinc and Cadmium Exchanges between Metallothionein and Carbonic Anhydrase.
26167879 2015 Domain Selection in Metallothionein 1A: Affinity-Controlled Mechanisms of Zinc Binding and Cadmium Exchange.
25208334 2014 The zinc balance: competitive zinc metalation of carbonic anhydrase and metallothionein 1A.
24140052 2013 Topographical analysis of As-induced folding of ?-MT1a.
23947958 2013 Expression of metallothionein and Nrf2 pathway genes in lung cancer and cancer-surrounding tissues.
23763497 2013 Increased metallothionein expression reflects steroid resistance in renal allograft recipients.
23506369 2013 Single-domain metallothioneins: evidence of the onset of clustered metal binding domains in Zn-rhMT 1a.
23501100 2013 Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells.
23429061 2013 Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-D-glucosaminidase (NAG) excretion in chronic lead-exposed workers.
23042264 2012 Expression of metallothionein I/II and Ki-67 antigen in various histological types of basal cell carcinoma.
22995156 2012 A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin.
22090273 2012 Overexpression of metallothionein I/II: a new feature of thyroid follicular cells in Graves' disease.
21798283 2011 Lack of association between autism and four heavy metal regulatory genes.
21103883 2011 Differentiation- and polarization-dependent zinc tolerance in Caco-2 cells.
20812968 2010 Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
20634891 2010 Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
20038220 2010 Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas.
19962295 2010 Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort.
19529947 2009 Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.
19515364 2009 Genetic background of lead and mercury metabolism in a group of medical students in Austria.
19359654 2009 Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure.
18601746 2008 The renal metallothionein expression profile is altered in human lupus nephritis.
18533113 2008 Noncooperative cadmium(II) binding to human metallothionein 1a.
18429853 2008 Metal exchange in metallothioneins: a novel structurally significant Cd(5) species in the alpha domain of human metallothionein 1a.
18349110 2008 Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.
18316168 2008 Effects of interleukin-6 -174C/G and metallothionein 1A +647A/C single-nucleotide polymorphisms on zinc-regulated gene expression in ageing.
18249147 2008 +647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications.
18208603 2008 Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues.
17388808 2007 Evidence for noncooperative metal binding to the alpha domain of human metallothionein.
17373731 2007 Metallothionein: an overview.
17111383 2007 Lipid raft-dependent endocytosis of metallothionein in HepG2 cells.
17008879 2007 Colocalization of glial fibrillary acidic protein, metallothionein, and MHC II in human, rat, NOD/SCID, and nude mouse skin keratinocytes and fibroblasts.
16955215 Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.
16827180 2006 Metallothionein 1 isoform gene expression induced by cadmium in human peripheral blood lymphocytes.
16778767 2006 The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.
16442532 2006 Interaction of metallothionein with tumor suppressor p53 protein.
16107899 2005 Interferon-alpha-induced changes in metallothionein expression in liver biopsies from patients with chronic hepatitis C.
16087360 2005 Effect of metallothionein on cell viability and its interactions with cadmium and zinc in HEK293 cells.
15812196 2005 Induction of metallothionein in proximal tubular cells by zinc and its potential as an endogenous antioxidant.
15616553 2004 The sequence and analysis of duplication-rich human chromosome 16.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14528913 2003 Metal binding to brain-specific metallothionein-3 studied by electrospray ionization mass spectrometry.
12970870 2003 Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene.
12539042 2003 HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12361735 2002 Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH.
11939525 2002 Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins.
11284736 2001 Influence of metallothionein-1 localization on its function.
11168427 2001 Metallothionein isogene transcription in red blood cell precursors from human cord blood.
10884303 2000 Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.
10774930 2000 Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes.
10754528 2000 Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.
10574972 1999 Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton.
10099782 1998 Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.
9614853 1998 Metallothionein-induced increase in mitochondrial inner membrane permeability.
9566988 1998 Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.
7543551 1995 Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine.
7140998 1982 Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR.
6327055 1984 Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.
6089206 1984 Human metallothionein genes are clustered on chromosome 16.
4062903 1985 Isolation and characterization of six human hepatic isometallothioneins.
3856101 1985 Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.
2304897 1990 Erythrocyte metallothionein as an index of zinc status in humans.
2303255 1990 The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia.