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Tbio
MSH5
MutS protein homolog 5

Protein Summary
Description
Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity). This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375703
  • ENSP00000364855
  • ENSG00000204410
  • ENST00000375740
  • ENSP00000364892
  • ENST00000375750
  • ENSP00000364903
  • ENST00000375755
  • ENSP00000364908
  • ENST00000412070
  • ENSP00000404892
  • ENSG00000230961
  • ENST00000416549
  • ENSP00000399721
  • ENSG00000235222
  • ENST00000419269
  • ENSP00000394649
  • ENST00000420731
  • ENSP00000400187
  • ENST00000427735
  • ENSP00000388037
  • ENSG00000230293
  • ENST00000435700
  • ENSP00000407047
  • ENST00000436091
  • ENSP00000396509
  • ENST00000436192
  • ENSP00000406868
  • ENSG00000227314
  • ENST00000441395
  • ENSP00000402659
  • ENST00000441401
  • ENSP00000406269
  • ENST00000448617
  • ENSP00000387609
  • ENST00000456839
  • ENSP00000394017
  • ENST00000457742
  • ENSP00000409181

Symbol
  • G7
  • NG23
  • POF13
  • MUTSH5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
virus perturbation
0.76
phenotype
0.74
cell line
0.64
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.25   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.25   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0