Property Summary

NCBI Gene PubMed Count 16
PubMed Score 13.86
PubTator Score 14.02

Knowledge Summary


No data available


  Disease (2)

Disease Target Count
Alzheimer's disease 644
Disease Target Count P-value
osteosarcoma 7933 8.3e-11
Waldenstrons macroglobulinemia 764 3.4e-03
sarcoidosis 368 1.3e-02
acute myeloid leukemia 785 2.9e-02


  Differential Expression (4)

Disease log2 FC p
Waldenstrons macroglobulinemia 3.993 3.4e-03
osteosarcoma -7.749 8.3e-11
sarcoidosis 1.100 1.3e-02
acute myeloid leukemia -3.400 2.9e-02


Accession Q96HJ5 A8MTP8 Q8NHW2
Symbols HTM4


PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (7)

25886616 Our data reveal MS4A3 as a novel direct target of EVI1 in human myeloid cells, and show that its repression plays a role in EVI1 mediated tumor aggressiveness.
20800603 Observational study of gene-disease association. (HuGE Navigator)
20677014 Observational study of gene-disease association. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
19818099 High HTm4 is associated with neoplasms.
15830103 The C-terminal domain is important for the function of HTm4 in cell cycle regulation.
15671017 HTm4 binding to KAP.Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2

AA Sequence

PNSV                                                                      211 - 214

Text Mined References (17)

PMID Year Title
25886616 2015 EVI1 promotes tumor growth via transcriptional repression of MS4A3.
24755620 2014 Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
22367966 2012 Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
20677014 2010 An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19818099 2011 Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
15830103 2005 [Regulatory role of HTm4 gene in hematopoietic cell cycle].
15671017 2005 Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11781350 2002 Human HTm4 is a hematopoietic cell cycle regulator.
11486273 2001 Structural organization of the human MS4A gene cluster on Chromosome 11q12.
11401424 2001 Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.
7524084 1994 Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.