1. Home
  2. Targets
  3. nucleic acid binding
  4. RNA binding protein
  5. ribosomal protein
  6. 28S ribosomal protein S2, mitochondrial

Tdark 28S ribosomal protein S2, mitochondrial

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 0.52
PubTator Score 0.36

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Brain glioma 7 3.786 1.9

Expression

  Differential Expression (3)

Disease log2 FC p
Multiple myeloma 1.052 2.3e-02
ovarian cancer 1.800 1.8e-05
pancreatic ductal adenocarcinoma liver m... -1.180 3.0e-02

Synonym

Accession Q9Y399 Q5T899 Q9BSQ4 MRP-S2
Symbols S2mt
CGI-91
MRP-S2

Gene

MRPS2

PANTHER Protein Class (3)

  Ortholog (13)

Species Source Disease
OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA

 UniProt Keyword (7)

 GO Function (1)

 GO Component (3)

 GO Process (4)

 Compartment GO Term (40)

See all...

 HCA RNA Cell Line (56)

See all...

Pathway (7)

Protein-protein Interaction (9)

MRPS9   MRPS23   MRPS27   TPD52   MRPS28   MRPS15   MRPS31   MRPS5   TPD52L2  

PDB (1)

Gene RIF (1)

AA Sequence 

MATSSAALPRILGAGARAPSRWLGFLGKATPRPARPSRRTLGSATALMIRESEDSTDFNDKILNEPLKHS      1 - 70
DFFNVKELFSVRSLFDARVHLGHKAGCRHRFMEPYIFGSRLDHDIIDLEQTATHLQLALNFTAHMAYRKG     71 - 140
IILFISRNRQFSYLIENMARDCGEYAHTRYFRGGMLTNARLLFGPTVRLPDLIIFLHTLNNIFEPHVAVR    141 - 210
DAAKMNIPTVGIVDTNCNPCLITYPVPGNDDSPLAVHLYCRLFQTAITRAKEKRQQVEALYRLQGQKEPG    211 - 280
DQGPAHPPGADMSHSL                                                          281 - 296
//

Text Mined References (13)

PMID Year Title