| Tdark | Ribosomal protein 63, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.5e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.4e-04 |
| Waldenstrons macroglobulinemia | 765 | 2.7e-03 |
| ovarian cancer | 8520 | 3.0e-03 |
| Multiple myeloma | 1332 | 5.9e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.3e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous neoplasm ... | 1.200 | 7.4e-04 |
| Multiple myeloma | 1.128 | 5.9e-03 |
| non primary Sjogren syndrome sicca | 1.100 | 1.3e-02 |
| ovarian cancer | -1.100 | 3.0e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.128 | 2.1e-02 |
| psoriasis | 1.400 | 2.5e-04 |
| Waldenstrons macroglobulinemia | 1.575 | 2.7e-03 |
