| Tdark | Ribosomal protein 63, mitochondrial |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 3.2e-06 |
| psoriasis | 6685 | 2.5e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 7.4e-04 |
| Waldenstrons macroglobulinemia | 764 | 2.7e-03 |
| Multiple myeloma | 1327 | 5.9e-03 |
| non primary Sjogren syndrome sicca | 840 | 1.3e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | 1.575 | 2.7e-03 |
| Multiple myeloma | 1.128 | 5.9e-03 |
| psoriasis | 1.400 | 2.5e-04 |
| pancreatic ductal adenocarcinoma liver m... | -1.128 | 2.1e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 7.4e-04 |
| non primary Sjogren syndrome sicca | 1.100 | 1.3e-02 |
| ovarian cancer | -1.400 | 3.2e-06 |
| PMID | Year | Title | |
|---|---|---|---|
| 25944712 | 2015 | N-terminome analysis of the human mitochondrial proteome. | |
| 23908630 | 2013 | Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 20877624 | 2010 | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15057823 | 2004 | The DNA sequence and analysis of human chromosome 13. | |
| 12706105 | 2003 | Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11543634 | 2001 | The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | |
| 11402041 | 2001 | Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. |
