Property Summary

NCBI Gene PubMed Count 18
PubMed Score 8.14
PubTator Score 8.18

Knowledge Summary


No data available


  Differential Expression (10)

Disease log2 FC p
psoriasis 1.400 1.3e-02
osteosarcoma -1.053 3.3e-03
non-small cell lung cancer 1.053 1.1e-16
lung cancer 2.600 1.1e-03
active Crohn's disease 1.562 8.9e-03
Breast cancer 2.500 3.9e-02
aldosterone-producing adenoma -1.541 6.9e-03
nasopharyngeal carcinoma 1.100 1.8e-03
ovarian cancer 2.000 3.0e-03
dermatomyositis 1.100 1.4e-03


Accession P49406 Q53TX9 Q96Q52 L19mt
Symbols RLX1



3J9M   3J7Y  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (7)

25448322 MRPL19 was initially implicated in dyslexia through family-based studies.
23954868 study failed to show any association of MRPL19 SNPs with developmental dyslexia in an Indian population.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20846247 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
17309879 Observational study of gene-disease association. (HuGE Navigator)
17309879 Study refined the 2p12 candidate region in two populations and report evidence supporting MRPL19 and C2ORF3 as candidate susceptibility genes for dyslexia.

AA Sequence

AIWKEIEASKRS                                                              281 - 292

Text Mined References (21)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25448322 2015 Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.
25278503 2014 Structure of the large ribosomal subunit from human mitochondria.
23954868 2013 Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21844884 2013 Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20846247 2011 Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
17309879 2007 A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12706105 2003 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11543634 2001 The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
11279069 2001 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.
10942595 2000 A visual intracellular classification strategy for uncharacterized human proteins.
10600119 1999 Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle.
9847074 1998 Toward a complete human genome sequence.
7788527 1995 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.