Tchem MRGPRX4 Mas-related G-protein coupled receptor member X4

Protein Summary

Description

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Uniprot Accession IDs

• Q96LA9
• Q3KNU3
• Q3KNU4
• Q502W0
• Q8TDD6
• Q8TDD7

Gene Name

• MRGPRX4

Ensembl ID

• ENST00000314254
• ENSP00000314042
• ENSG00000179817

Symbol

• MRGX4
• SNSR5
• SNSR6
• GPCR
• MRGX4
• SNSR6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.58
tissue	0.42
protein domain	0.41
phenotype	0.4
protein complex	0.4

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Mas Proto-oncogene And Mas-related (Mrgs) Receptor / Mas-related G-protein Coupled Receptor Member X4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0