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Tbio Metallophosphoesterase 1

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.

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Property Summary

NCBI Gene PubMed Count 10
PubMed Score 3.78
PubTator Score 7.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count
Bipolar Disorder 666
Disease Target Count P-value
osteosarcoma 7950 2.6e-07

Expression

  Differential Expression (1)

Disease log2 FC p
osteosarcoma -1.540 2.6e-07

Synonym

Accession Q53F39 B0YJ39 B0YJ40 B0YJ41 B5ME53 B7WNJ3 D3DUI5 D3DUI7 Q6GMP1 Q8TAD6 Q8TE26 Q8WZ32 Q9BU58 Q9H958 Q9HAI4
Symbols PGAP5

Gene

MPPE1

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (3)

 GO Component (8)

 GO Process (2)

 Compartment GO Term (34)

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 HCA RNA Cell Line (56)

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Protein-protein Interaction (70)

GLB1L2   HSPA5   CANX   ALG9   IMPAD1   CCPG1   PLXNB2   EXT1   ATF6B   TMEM214   FUT8   SPPL2B   POMT2   TMEM186   LMF2   PBXIP1   POMT1   MR1   SUSD1   EDEM1   EXTL3   PLXNA2   GALNT12   GALNT4   FAM69A   ADAM10   GALNT7   GINM1   FZD2   TMEM59L   TMBIM6   GPC4   CNTNAP3B   ICAM4   UGT8   SUN2   UGT3A2   LRRC3   TMEM192   LRP12   TMEM39A   CHST12   CSGALNACT2   ABCA3   LARGE2   AMIGO1   SEMA6A   USP30   ERMP1   DHFR2   PIGB   HTATIP2   SUN1   B4GALT7   BACE2   CGRRF1   NXPE3   ALG12   FAM189B   TXNDC15   HLA-DRB1   BTN2A2   CMTM4   GAS6   LRFN3   UXS1   ECEL1   FKRP   HYAL2   TMEM132A  

Gene RIF (5)

AA Sequence 

MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVL      1 - 70
KAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQ     71 - 140
KMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSET    141 - 210
EAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYD    211 - 280
VLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCY    281 - 350
LPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR                            351 - 396
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Text Mined References (13)

PMID Year Title