Tbio MPC1 Mitochondrial pyruvate carrier 1

Protein Summary

Description

Mediates the uptake of pyruvate into mitochondria. The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9Y5U8
• B2R5I7
• Q5TI66
• Q9HB67
• Q9UQN4

Gene Name

• MPC1

Ensembl ID

• ENST00000360961
• ENSP00000354223
• ENSG00000060762

Symbol

• BRP44L
• MPYCD
• BRP44L
• CGI-129
• SLC54A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor perturbation	0.91
histone modification site profile	0.89
kinase perturbation	0.81
transcription factor binding site profile	0.69

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc54 Mitochondrial Pyruvate Carriers / Mitochondrial Pyruvate Carrier 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.5   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.5   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0