Tdark MOSPD1 Motile sperm domain-containing protein 1

Protein Summary

Description

Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.

Uniprot Accession IDs

• Q9UJG1
• B2RE62
• D3DTG5
• Q5H9C5
• Q5H9C7

Gene Name

• MOSPD1

Ensembl ID

• ENST00000370777
• ENSP00000359813
• ENSG00000101928
• ENST00000370779
• ENSP00000359815
• ENST00000370783
• ENSP00000359819

Symbol

• DJ473B4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.77
microRNA	0.73
transcription factor perturbation	0.61
virus perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.05   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0