| Tchem | Neutrophil collagenase |
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Comments
Property Summary
| Ligand Count | 878 |
| NCBI Gene PubMed Count | 187 |
| PubMed Score | 2433.69 |
| PubTator Score | 514.18 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Dermatitis, Contact | 71 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Lung diseases | 50 | 0.0 | 0.0 |
| Melanoma | 711 | 0.0 | 0.5 |
| Wounds and Injuries | 18 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Contact Dermatitis | 81 |
| Major Depressive Disorder | 301 |
| Unipolar Depression | 250 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.8e-08 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 1.0e-02 |
| Disease | Target Count |
|---|---|
| Preterm premature rupture of membranes | 2 |
| Disease | log2 FC | p |
|---|---|---|
| mucosa-associated lymphoid tissue lympho... | 5.318 | 1.0e-02 |
| osteosarcoma | -4.809 | 2.8e-08 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL1160685
pIC50 6.00
CHEMBL95483
pIC50 6.00
CHEMBL3221864
pIC50 6.00
CHEMBL3221863
pIC50 6.00
CHEMBL515083
pIC50 6.00
CHEMBL291898
pIC50 6.00
CHEMBL292636
pIC50 6.00
CHEMBL141672
pIC50 6.00
CHEMBL298814
pIC50 6.00
CHEMBL170103
pKi 6.00
CHEMBL172180
pKi 6.00
CHEMBL3142592
pKi 6.00
CHEMBL1084509
pIC50 6.00
CHEMBL574589
pIC50 6.00
CHEMBL122925
pKi 6.00
CHEMBL3675553
pKi 6.03
CHEMBL1770700
pIC50 6.05
CHEMBL3670696
pKi 6.05
CHEMBL1234370
pIC50 6.06
CHEMBL3675575
pKi 6.06
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF 1 - 70 GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELW 71 - 140 SVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN 141 - 210 LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCD 211 - 280 PSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW 281 - 350 ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI 351 - 420 ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 421 - 467 //
