| Tchem | Neutrophil collagenase |
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Comments
Property Summary
| NCBI Gene PubMed Count | 170 |
| Grant Count | 328 |
| R01 Count | 139 |
| Funding | $55,980,389.93 |
| PubMed Score | 2172.36 |
| PubTator Score | 514.18 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -6.320 | 0.000 |
| mucosa-associated lymphoid tissue lympho... | 5.318 | 0.010 |
CHEMBL1160685
pIC50 6.00
CHEMBL95483
pIC50 6.00
CHEMBL3221864
pIC50 6.00
CHEMBL3221863
pIC50 6.00
CHEMBL515083
pIC50 6.00
CHEMBL291898
pIC50 6.00
CHEMBL292636
pIC50 6.00
CHEMBL141672
pIC50 6.00
CHEMBL298814
pIC50 6.00
CHEMBL170103
pKi 6.00
CHEMBL172180
pKi 6.00
CHEMBL3142592
pKi 6.00
CHEMBL1084509
pIC50 6.00
CHEMBL574589
pIC50 6.00
CHEMBL122925
pKi 6.00
CHEMBL3675553
pKi 6.03
CHEMBL1770700
pIC50 6.05
CHEMBL3670696
pKi 6.05
CHEMBL1234370
pIC50 6.06
CHEMBL3675575
pKi 6.06
| PMID | Text |
|---|---|
| 27442388 | Suggest that MMP-8 polymorphism -799 C/T was a risk for developing chronic periapical lesions. |
| 26872724 | The reciprocal positive interplay between MMP-8 and TGF-beta1 contributes to HCC invasion and metastasis by inducing EMT mainly through the PI3K/Akt/Rac1 pathway. |
| 26773532 | EMMPRIN, MMP8, hyaluronan, beta-defensing-2, and neutrophil gelatinase-associated lipocalin (NGAL) are elevated in women with vaginal inflammation |
| 26577236 | Initial analysis of the MMP8 gene showed suggestive association between rs1940475 and knee OA, but the finding did not replicate in other study cohorts, even though the trend for predisposing allele was similar in all five cohorts. MMP-8 is a good biological candidate for OA, but our study did not find common variants with significant association in the gene. |
| 26462905 | amniotic fluid concentrations in acute-chorioamnionitis distinctly decrease throughout preterm-gestation |
| 26418236 | Sputum, serum, and urine MMP-8 were not significantly changed in COPD exacerbation compared to recovery values. |
| 26339374 | miR-539 plays a key role in inhibiting osteosarcoma cell invasion and migration and can regulate MMP8 expression in osteosarcoma cells. |
| 26132583 | salivary levels of the analyzed biomarkers MMP-8, -9, MPO are associated with periodontal status. However, these biomarkers could not differentiate between patients with or without a MI. |
| 25841875 | Positive results of the aMMP-8 test significantly correlate with generalized ChP. The aMMP-8 test may be used by physicians to detect periodontitis in their patients. |
| 25712810 | increased levels in saliva and serum in women with polycystic ovary syndrome, and is potentiated in the presence of gingivitis |
| More... |
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFF 1 - 70 GLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELW 71 - 140 SVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYN 141 - 210 LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCD 211 - 280 PSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYW 281 - 350 ALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI 351 - 420 ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG 421 - 467 //
| PMID | Year | Title |
|---|---|---|
| 27442388 | 2015 | Matrix Matalloproteinase-8 Gene Polymorphism in Chronic Periapical Lesions. |
| 26872724 | 2016 | Reciprocal activation between MMP-8 and TGF-?1 stimulates EMT and malignant progression of hepatocellular carcinoma. |
| 26773532 | 2016 | Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators. |
| 26577236 | 2016 | Association study of MMP8 gene in osteoarthritis. |
| 26462905 | 2015 | The inflammatory milieu of amniotic fluid in acute-chorioamnionitis decreases with increasing gestational age. |
| 26418236 | 2016 | Matrix metalloproteinases -8 and -9 in the Airways, Blood and Urine During Exacerbations of COPD. |
| 26339374 | 2015 | MicroRNA-539 suppresses osteosarcoma cell invasion and migration in vitro and targeting Matrix metallopeptidase-8. |
| 26132583 | 2015 | Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease). |
| 25841875 | 2015 | Activated matrix metalloproteinase-8 in saliva as diagnostic test for periodontal disease? A case-control study. |
| 25712810 | 2015 | Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation. |
| More... |
