| Tbio | Matrix metalloproteinase-24 |
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin (By similarity).
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). [provided by RefSeq, Feb 2016]
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). [provided by RefSeq, Feb 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neoplasm Metastasis | 168 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 5.4e-15 |
| ovarian cancer | 8520 | 6.2e-10 |
| malignant mesothelioma | 3232 | 4.1e-07 |
| Astrocytoma, Pilocytic | 3081 | 9.3e-07 |
| glioblastoma | 5792 | 1.9e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.7e-05 |
| medulloblastoma, large-cell | 6241 | 3.8e-05 |
| osteosarcoma | 7950 | 4.8e-05 |
| psoriasis | 6694 | 9.9e-05 |
| adult high grade glioma | 3801 | 1.6e-03 |
| group 4 medulloblastoma | 1855 | 1.7e-03 |
| non primary Sjogren syndrome sicca | 891 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Attention deficit hyperactivity disorder | 278 | 0.0 | 1.1 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Asymptomatic dengue | 5 | 3.776 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.300 | 1.6e-03 |
| Astrocytoma, Pilocytic | -1.500 | 9.3e-07 |
| atypical teratoid / rhabdoid tumor | -1.300 | 3.7e-05 |
| ependymoma | -1.700 | 5.4e-15 |
| glioblastoma | -1.200 | 1.9e-06 |
| group 4 medulloblastoma | 1.700 | 1.7e-03 |
| malignant mesothelioma | -1.600 | 4.1e-07 |
| medulloblastoma, large-cell | -1.500 | 3.8e-05 |
| non primary Sjogren syndrome sicca | 1.100 | 1.6e-02 |
| osteosarcoma | -1.020 | 4.8e-05 |
| ovarian cancer | -1.200 | 6.2e-10 |
| psoriasis | -1.500 | 9.9e-05 |
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVA 1 - 70 RADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 71 - 140 VPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHE 141 - 210 IKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVA 211 - 280 VHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSP 281 - 350 SERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQ 351 - 420 FWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYF 421 - 490 FKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPR 491 - 560 NILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTG 561 - 630 PQPVTYYKRPVQEWV 631 - 645 //
