Tchem | Interstitial collagenase |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Comments
Property Summary
Ligand Count | 1,452 |
NCBI Gene PubMed Count | 838 |
PubMed Score | 2656.79 |
PubTator Score | 2137.39 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 9.6e-21 |
breast carcinoma | 1638 | 1.1e-17 |
psoriasis | 6694 | 8.3e-13 |
cystic fibrosis | 1696 | 4.5e-10 |
malignant mesothelioma | 3232 | 5.1e-07 |
periodontitis | 293 | 1.4e-06 |
ulcerative colitis | 1819 | 1.6e-06 |
cutaneous lupus erythematosus | 1057 | 3.3e-06 |
lung adenocarcinoma | 2716 | 5.4e-05 |
Breast cancer | 3578 | 1.4e-04 |
interstitial cystitis | 2312 | 4.2e-04 |
lung cancer | 4740 | 5.5e-04 |
pancreatic cancer | 2398 | 7.7e-04 |
nasopharyngeal carcinoma | 1058 | 4.1e-03 |
Atopic dermatitis | 952 | 6.2e-03 |
ductal carcinoma in situ | 1745 | 9.9e-03 |
esophageal adenocarcinoma | 737 | 1.8e-02 |
Barrett's esophagus | 182 | 2.0e-02 |
ovarian cancer | 8520 | 2.3e-02 |
invasive ductal carcinoma | 2951 | 4.2e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Arthritis | 290 | 6.09 | 3.0 |
Cancer | 2499 | 5.382 | 2.7 |
Periodontal disease | 40 | 5.225 | 2.6 |
Lung disease | 142 | 4.002 | 2.0 |
Synovitis | 78 | 3.966 | 2.0 |
Coronary artery disease | 268 | 3.845 | 1.9 |
Heart disease | 306 | 3.828 | 1.9 |
Systemic scleroderma | 60 | 3.82 | 1.9 |
Degenerative disc disease | 35 | 3.81 | 1.9 |
Aortic aneurysm | 38 | 3.543 | 1.8 |
Localized scleroderma | 9 | 3.474 | 1.7 |
Glaucoma | 239 | 3.439 | 1.7 |
Hypertension | 396 | 3.287 | 1.6 |
Conjunctivochalasis | 6 | 3.282 | 1.6 |
Skin disease | 66 | 3.238 | 1.6 |
tuberculosis | 2010 | 3.17 | 1.6 |
Disease | Target Count |
---|---|
COPD | 118 |
Recessive dystrophic epidermolysis bullosa | 2 |
Disease | log2 FC | p |
---|---|---|
Atopic dermatitis | 1.800 | 6.2e-03 |
Barrett's esophagus | 3.200 | 2.0e-02 |
Breast cancer | 2.400 | 1.4e-04 |
breast carcinoma | 1.600 | 1.1e-17 |
cutaneous lupus erythematosus | 5.700 | 3.3e-06 |
cystic fibrosis | 8.976 | 4.5e-10 |
ductal carcinoma in situ | 2.600 | 9.9e-03 |
esophageal adenocarcinoma | 4.600 | 1.8e-02 |
interstitial cystitis | 5.500 | 4.2e-04 |
invasive ductal carcinoma | 2.351 | 4.2e-02 |
lung adenocarcinoma | 2.100 | 5.4e-05 |
lung cancer | 1.600 | 5.5e-04 |
malignant mesothelioma | -1.600 | 5.1e-07 |
nasopharyngeal carcinoma | 2.900 | 4.1e-03 |
non-small cell lung cancer | 5.110 | 9.6e-21 |
ovarian cancer | 1.600 | 2.3e-02 |
pancreatic cancer | 2.700 | 7.7e-04 |
periodontitis | 1.100 | 1.4e-06 |
psoriasis | 1.700 | 8.3e-13 |
ulcerative colitis | 6.900 | 1.6e-06 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
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MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEF 1 - 70 FGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQL 71 - 140 WSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREY 141 - 210 NLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDS 211 - 280 KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWA 281 - 350 VQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 351 - 420 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 421 - 469 //