| Tchem | Interstitial collagenase |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Comments
Property Summary
| Ligand Count | 1,448 |
| NCBI Gene PubMed Count | 838 |
| PubMed Score | 2656.79 |
| PubTator Score | 2137.39 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 9.6e-21 |
| breast carcinoma | 1638 | 1.1e-17 |
| psoriasis | 6694 | 8.3e-13 |
| cystic fibrosis | 1696 | 4.5e-10 |
| malignant mesothelioma | 3232 | 5.1e-07 |
| periodontitis | 293 | 1.4e-06 |
| ulcerative colitis | 1819 | 1.6e-06 |
| cutaneous lupus erythematosus | 1057 | 3.3e-06 |
| lung adenocarcinoma | 2716 | 5.4e-05 |
| Breast cancer | 3578 | 1.4e-04 |
| interstitial cystitis | 2312 | 4.2e-04 |
| lung cancer | 4740 | 5.5e-04 |
| pancreatic cancer | 2398 | 7.7e-04 |
| nasopharyngeal carcinoma | 1058 | 4.1e-03 |
| Atopic dermatitis | 952 | 6.2e-03 |
| ductal carcinoma in situ | 1745 | 9.9e-03 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| Barrett's esophagus | 182 | 2.0e-02 |
| ovarian cancer | 8520 | 2.3e-02 |
| invasive ductal carcinoma | 2951 | 4.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis | 290 | 6.09 | 3.0 |
| Cancer | 2499 | 5.382 | 2.7 |
| Periodontal disease | 40 | 5.225 | 2.6 |
| Lung disease | 142 | 4.002 | 2.0 |
| Synovitis | 78 | 3.966 | 2.0 |
| Coronary artery disease | 268 | 3.845 | 1.9 |
| Heart disease | 306 | 3.828 | 1.9 |
| Systemic scleroderma | 60 | 3.82 | 1.9 |
| Degenerative disc disease | 35 | 3.81 | 1.9 |
| Aortic aneurysm | 38 | 3.543 | 1.8 |
| Localized scleroderma | 9 | 3.474 | 1.7 |
| Glaucoma | 239 | 3.439 | 1.7 |
| Hypertension | 396 | 3.287 | 1.6 |
| Conjunctivochalasis | 6 | 3.282 | 1.6 |
| Skin disease | 66 | 3.238 | 1.6 |
| tuberculosis | 2010 | 3.17 | 1.6 |
| Disease | Target Count |
|---|---|
| COPD | 118 |
| Recessive dystrophic epidermolysis bullosa | 2 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | 1.800 | 6.2e-03 |
| Barrett's esophagus | 3.200 | 2.0e-02 |
| Breast cancer | 2.400 | 1.4e-04 |
| breast carcinoma | 1.600 | 1.1e-17 |
| cutaneous lupus erythematosus | 5.700 | 3.3e-06 |
| cystic fibrosis | 8.976 | 4.5e-10 |
| ductal carcinoma in situ | 2.600 | 9.9e-03 |
| esophageal adenocarcinoma | 4.600 | 1.8e-02 |
| interstitial cystitis | 5.500 | 4.2e-04 |
| invasive ductal carcinoma | 2.351 | 4.2e-02 |
| lung adenocarcinoma | 2.100 | 5.4e-05 |
| lung cancer | 1.600 | 5.5e-04 |
| malignant mesothelioma | -1.600 | 5.1e-07 |
| nasopharyngeal carcinoma | 2.900 | 4.1e-03 |
| non-small cell lung cancer | 5.110 | 9.6e-21 |
| ovarian cancer | 1.600 | 2.3e-02 |
| pancreatic cancer | 2.700 | 7.7e-04 |
| periodontitis | 1.100 | 1.4e-06 |
| psoriasis | 1.700 | 8.3e-13 |
| ulcerative colitis | 6.900 | 1.6e-06 |
CHEMBL289222
pIC50 6.00
CHEMBL312649
pKi 6.00
CHEMBL100273
pIC50 6.00
CHEMBL311618
pIC50 6.00
CHEMBL124265
pIC50 6.00
CHEMBL40746
pKi 6.00
CHEMBL1801412
pIC50 6.00
CHEMBL40151
pIC50 6.00
CHEMBL287871
pIC50 6.00
CHEMBL293382
pIC50 6.00
CHEMBL153469
pKi 6.00
CHEMBL75641
pIC50 6.00
CHEMBL295066
pIC50 6.00
CHEMBL125281
pIC50 6.00
CHEMBL343378
pKi 6.00
CHEMBL1766903
pIC50 6.00
CHEMBL1801422
pIC50 6.00
CHEMBL1957602
pIC50 6.00
CHEMBL450479
pIC50 6.01
CHEMBL74954
pIC50 6.01
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEF 1 - 70 FGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQL 71 - 140 WSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREY 141 - 210 NLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDS 211 - 280 KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWA 281 - 350 VQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 351 - 420 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 421 - 469 //
