| Tchem | Interstitial collagenase |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Comments
Property Summary
| NCBI Gene PubMed Count | 782 |
| Grant Count | 502 |
| R01 Count | 322 |
| Funding | $45,846,504.16 |
| PubMed Score | 2529.49 |
| PubTator Score | 2137.39 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -1.600 | 0.000 |
| Barrett's esophagus | 3.200 | 0.020 |
| esophageal adenocarcinoma | 4.600 | 0.018 |
| cutaneous lupus erythematosus | 5.700 | 0.000 |
| cystic fibrosis | 8.976 | 0.000 |
| periodontitis | 1.100 | 0.000 |
| Atopic dermatitis | 1.800 | 0.006 |
| non-small cell lung cancer | 5.110 | 0.000 |
| lung cancer | 1.600 | 0.001 |
| pancreatic cancer | 2.700 | 0.001 |
| interstitial cystitis | 5.500 | 0.000 |
| lung adenocarcinoma | 3.700 | 0.000 |
| psoriasis | 3.800 | 0.000 |
| invasive ductal carcinoma | 3.400 | 0.039 |
| nasopharyngeal carcinoma | 2.900 | 0.004 |
| inflammatory breast cancer | 3.800 | 0.011 |
| breast carcinoma | 1.600 | 0.000 |
| ductal carcinoma in situ | 2.600 | 0.010 |
| ulcerative colitis | 6.900 | 0.000 |
| ovarian cancer | 1.600 | 0.023 |
CHEMBL289222
pIC50 6.00
CHEMBL312649
pKi 6.00
CHEMBL100273
pIC50 6.00
CHEMBL311618
pIC50 6.00
CHEMBL124265
pIC50 6.00
CHEMBL40746
pKi 6.00
CHEMBL1801412
pIC50 6.00
CHEMBL40151
pIC50 6.00
CHEMBL287871
pIC50 6.00
CHEMBL293382
pIC50 6.00
CHEMBL153469
pKi 6.00
CHEMBL75641
pIC50 6.00
CHEMBL295066
pIC50 6.00
CHEMBL125281
pIC50 6.00
CHEMBL343378
pKi 6.00
CHEMBL1766903
pIC50 6.00
CHEMBL1801422
pIC50 6.00
CHEMBL1957602
pIC50 6.00
CHEMBL450479
pIC50 6.01
CHEMBL74954
pIC50 6.01
| PMID | Text |
|---|---|
| 27060293 | Cross-talk between macrophages and smooth muscle cells impairs collagen synthesis and MMP1/9 activity, promoting angiogenesis. |
| 26973196 | determined normal concentration ranges for MMP-1, MMP-2, MMP-9, TIMP-1, and ratios of concentrations of MMPs and TIMP-1 (MMP-1/TIMP-1, MMP-2/TIMP-1, MMP-9/TIMP-1) in the amniotic fluid at the first period of labor in physiological pregnancy. |
| 26891870 | ZBP-89 regulates of MMP-1 expression in response to inflammatory cytokines. |
| 26782559 | MMP-1 expression is increased in intervertebral disc degeneration, with higher expression observed in more severe cases, whereas TIMP-1 expression was similarly expressed in both normal and degenerated discs. |
| 26751737 | These observations suggest a novel role of BMP-6 in the inhibition of breast cancer metastasis by regulating secretion of MMPs(MMP-1) in the tumor microenvironment. |
| 26600542 | the serum levels of MMP-2 and MMP-9 proteins were higher in patients with OA than in controls, while MMP-1 and MMP-9 protein expressions were higher in the synovial joint fluid of patients with osteoarthritis than in controls. |
| 26510114 | MMP-1 haplotypes association with susceptibility and severity of juvenile idiopathic arthritis |
| 26367274 | MTBRa activates TLR2/ERK signalings to induce TNF-alpha and elicit MMP-1 and MMP-9 in human PMCs, which are associated with effusion volume and pleural fibrosis and may contribute to pathogenesis of TBP. |
| 26363461 | The -1607 1G/2G polymorphism of MMP-1 promoter may be related to the susceptibility to ADDWOR with or without TMJ OA. |
| 26305549 | Data show that blocking the interleukin-8 (IL-8)/androgen receptor (AR)/matrix metalloproteinases (MMPs) signals partially reversed the infiltrating B cells capacity to increase the bladder cancer (BCa) cell invasion. |
| More... |
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEF 1 - 70 FGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQL 71 - 140 WSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREY 141 - 210 NLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDS 211 - 280 KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWA 281 - 350 VQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 351 - 420 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 421 - 469 //
| PMID | Year | Title |
|---|---|---|
| 27060293 | 2016 | Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis. |
| 26973196 | [Reference ranges of matrix metalloproteinase-1, -2, -9 and tissue inhibitor of matrix metalloproteinases-1 concentrations in amniotic fluid in physiological pregnancy]. | |
| 26891870 | 2016 | Zinc-binding protein-89 (ZBP-89) cooperates with NF-?B to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines. |
| 26782559 | 2015 | Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration. |
| 26751737 | 2016 | BMP-6 inhibits the metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression. |
| 26600542 | 2015 | High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. |
| 26510114 | 2015 | Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis. |
| 26367274 | 2015 | Mycobacterium tuberculosis Upregulates TNF-? Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells. |
| 26363461 | 2015 | Association between polymorphism of MMP-1 promoter and the susceptibility to anterior disc displacement and temporomandibular joint osteoarthritis. |
| 26305549 | 2015 | Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals. |
| More... |
