Tbio MMD Monocyte to macrophage differentiation factor

Protein Summary

Description

Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion. This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15546
• B2R6X9
• D3DTY6
• Q8TAN7

Gene Name

• MMD

Ensembl ID

• ENST00000262065
• ENSP00000262065
• ENSG00000108960

Symbol

• PAQR11
• MMA
• MMD1
• PAQR11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
PubMedID	0.91
kinase perturbation	0.84
small molecule perturbation	0.76
cellular component	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / Monocyte To Macrophage Differentiation Factor

DTO Classes

Protein / Receptor / Monocyte To Macrophage Differentiation Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.86   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0