Property Summary

NCBI Gene PubMed Count 21
PubMed Score 2336.66
PubTator Score 30.59

Knowledge Summary


No data available


  Differential Expression (7)

Disease log2 FC p
psoriasis 1.100 1.3e-03
osteosarcoma 2.337 6.2e-10
glioblastoma 1.200 9.7e-04
medulloblastoma, large-cell 1.300 2.4e-03
lung cancer 1.200 6.3e-03
group 3 medulloblastoma 1.400 8.7e-05
ovarian cancer 1.600 4.3e-05

Gene RIF (6)

25640402 Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
24857747 MYC is part of a network of bHLHLZ proteins centered on the MYC heterodimeric partner MAX and its counterpart, the MAX-like protein MLX.
18458340 These studies suggest a key role for MondoA:Mlx complexes in the adaptive transcriptional response to changes in extracellular glucose concentration and peripheral glucose uptake.
16782875 Endogenous MondoA and Mlx associate with mitochondria in primary skeletal muscle.
15664996 Mlx is an obligatory partner of ChREBP in regulating lipogenic enzyme genes in liver.
12446771 Data show that for both MondoA and Mlx, the C-terminal domain CRM-1 has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm.

AA Sequence

TLREIVIGVLHQLKNQLY                                                        281 - 298

Text Mined References (23)

PMID Year Title
25640402 2015 Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis.
25416956 2014 A proteome-scale map of the human interactome network.
24857747 2015 Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23756994 2013 Classification and evolutionary analysis of the basic helix-loop-helix gene family in the green anole lizard, Anolis carolinensis.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22458338 2012 Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.
21102463 2010 Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
18458340 2008 Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.
16782875 2006 MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15664996 2005 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12446771 2002 A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex.
11230181 2001 WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.
10918583 2000 Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?
10593926 1999 Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors.
8973301 1996 TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
7490091 1995 Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.