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Tchem
MLNR
Motilin receptor

Protein Summary
Description
Receptor for motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218721
  • ENSP00000218721
  • ENSG00000102539

Symbol
  • GPR38
  • MTLR
  • MTLR1
  • GPR38
  • MTLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.76
histone modification site profile
0.57
cell line
0.49
cell type or tissue
0.47
disease
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.33   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.33   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 180
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1