| Tbio | Protein AF-10 |
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Comments
| Disease | Target Count |
|---|---|
| Leukemia, Myelocytic, Acute | 120 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 9.4e-11 |
| Pick disease | 1894 | 1.1e-05 |
| osteosarcoma | 7950 | 1.4e-04 |
| medulloblastoma, large-cell | 6241 | 3.3e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.2e-04 |
| Rheumatoid arthritis | 1191 | 7.6e-04 |
| glioblastoma | 5792 | 1.7e-03 |
| oligodendroglioma | 2850 | 4.6e-03 |
| astrocytic glioma | 2597 | 5.7e-03 |
| ependymoma | 4679 | 6.5e-03 |
| primitive neuroectodermal tumor | 3035 | 7.9e-03 |
| group 3 medulloblastoma | 4104 | 8.8e-03 |
| aldosterone-producing adenoma | 665 | 1.5e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.4e-02 |
| lung cancer | 4740 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast cancer | 3578 | 0.0 | 3.0 |
| Disease of cellular proliferation | 3 | 0.0 | 3.0 |
| ovarian cancer | 8520 | 0.0 | 4.1703756913735E-8 |
| Disease | Target Count |
|---|---|
| Renal Cell Carcinoma | 214 |
| acute T cell leukemia | 17 |
| Disease | log2 FC | p |
|---|---|---|
| ovarian cancer | -1.400 | 4.2e-08 |
| aldosterone-producing adenoma | -1.010 | 1.5e-02 |
| astrocytic glioma | -1.600 | 5.7e-03 |
| atypical teratoid / rhabdoid tumor | 2.000 | 4.2e-04 |
| ependymoma | -1.700 | 6.5e-03 |
| glioblastoma | 1.600 | 1.7e-03 |
| group 3 medulloblastoma | 1.500 | 8.8e-03 |
| lung cancer | 1.600 | 3.7e-02 |
| medulloblastoma, large-cell | 2.100 | 3.3e-04 |
| non primary Sjogren syndrome sicca | -1.100 | 2.4e-02 |
| oligodendroglioma | -1.500 | 4.6e-03 |
| osteosarcoma | 1.661 | 1.4e-04 |
| Pick disease | 1.800 | 1.1e-05 |
| primitive neuroectodermal tumor | 1.700 | 7.9e-03 |
| psoriasis | -1.200 | 9.4e-11 |
| Rheumatoid arthritis | 1.800 | 7.6e-04 |
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRK 1 - 70 CESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYIC 71 - 140 DEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNR 141 - 210 SYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLK 211 - 280 RLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQ 281 - 350 GSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGL 351 - 420 PSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENV 421 - 490 SHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSEL 491 - 560 LNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTL 561 - 630 SGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQ 631 - 700 PGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKER 701 - 770 LQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQS 771 - 840 TSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAIN 841 - 910 GIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNS 911 - 980 QQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNAS 981 - 1050 QKVARLSDKTGPVAQEKS 1051 - 1068 //
