Tbio | Protein AF-10 |
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Comments
Disease | Target Count |
---|---|
Leukemia, Myelocytic, Acute | 120 |
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6694 | 9.4e-11 |
Pick disease | 1894 | 1.1e-05 |
osteosarcoma | 7950 | 1.4e-04 |
medulloblastoma, large-cell | 6241 | 3.3e-04 |
atypical teratoid / rhabdoid tumor | 5112 | 4.2e-04 |
Rheumatoid arthritis | 1191 | 7.6e-04 |
glioblastoma | 5792 | 1.7e-03 |
oligodendroglioma | 2850 | 4.6e-03 |
astrocytic glioma | 2597 | 5.7e-03 |
ependymoma | 4679 | 6.5e-03 |
primitive neuroectodermal tumor | 3035 | 7.9e-03 |
group 3 medulloblastoma | 4104 | 8.8e-03 |
aldosterone-producing adenoma | 665 | 1.5e-02 |
non primary Sjogren syndrome sicca | 891 | 2.4e-02 |
lung cancer | 4740 | 3.7e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Breast cancer | 3578 | 0.0 | 3.0 |
Disease of cellular proliferation | 3 | 0.0 | 3.0 |
ovarian cancer | 8520 | 0.0 | 4.1703756913735E-8 |
Disease | Target Count |
---|---|
Renal Cell Carcinoma | 214 |
acute T cell leukemia | 17 |
Disease | log2 FC | p |
---|---|---|
ovarian cancer | -1.400 | 4.2e-08 |
aldosterone-producing adenoma | -1.010 | 1.5e-02 |
astrocytic glioma | -1.600 | 5.7e-03 |
atypical teratoid / rhabdoid tumor | 2.000 | 4.2e-04 |
ependymoma | -1.700 | 6.5e-03 |
glioblastoma | 1.600 | 1.7e-03 |
group 3 medulloblastoma | 1.500 | 8.8e-03 |
lung cancer | 1.600 | 3.7e-02 |
medulloblastoma, large-cell | 2.100 | 3.3e-04 |
non primary Sjogren syndrome sicca | -1.100 | 2.4e-02 |
oligodendroglioma | -1.500 | 4.6e-03 |
osteosarcoma | 1.661 | 1.4e-04 |
Pick disease | 1.800 | 1.1e-05 |
primitive neuroectodermal tumor | 1.700 | 7.9e-03 |
psoriasis | -1.200 | 9.4e-11 |
Rheumatoid arthritis | 1.800 | 7.6e-04 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG |
MVSSDRPVSLEDEVSHSMKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACYGIVQVPTGPWFCRK 1 - 70 CESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYIC 71 - 140 DEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNR 141 - 210 SYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLK 211 - 280 RLEDTTARFTNANFQEVSAHTSSGKDVSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQ 281 - 350 GSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDVHKGESGSQEGGVNSFSTLIGL 351 - 420 PSTSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQENV 421 - 490 SHLSVSSASPTSSVASAAGSITSSSLQKSPTLLRNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSEL 491 - 560 LNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAVATTQANTL 561 - 630 SGSSLSQAPSHMYGNRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSLQIRYDQ 631 - 700 PGNSSLENLPPVAASIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKER 701 - 770 LQLLNAQLSVPFPTITANPSPSHQIHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQDLTSSGQS 771 - 840 TSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQPVTSTIPAVSAVGGIIGALPGNQLAIN 841 - 910 GIVGALNGVMQTPVTMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGLLSDQQRQILIHQQQFQQLLNS 911 - 980 QQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPGPTQIPINNLLAGTQAPPLHTATTNPFLTIHGDNAS 981 - 1050 QKVARLSDKTGPVAQEKS 1051 - 1068 //