Property Summary

NCBI Gene PubMed Count 11
PubMed Score 10.42
PubTator Score 5.01

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 3.42672081668712E-17
osteosarcoma 7933 4.90090988140868E-6
glioblastoma 5572 4.23202454278024E-5
psoriasis 6685 4.47503870058884E-5
group 3 medulloblastoma 2254 4.68372392453456E-4
adrenocortical carcinoma 1427 7.37380860675367E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00295303555304171
Rheumatoid Arthritis 1171 0.00440324268899587
ovarian cancer 8492 0.00631740572166099
medulloblastoma, large-cell 6234 0.0103408680896546
intraductal papillary-mucinous adenoma (IPMA) 2956 0.010798832497124
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0121084301185358
Disease Target Count Z-score Confidence
Laryngeal squamous cell carcinoma 6 3.669 1.8

Expression

Synonym

Accession Q6P0N0 D3DSA7 Q86V14 Q96PY4 Q9NUR5 Q9Y4X9
Symbols KNL2
M18BP1
C14orf106
HSA242977

Gene

PDB

1WGX  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG
Zebrafish OMA EggNOG

 GO Function (1)

 IMPC Term (1)

Gene RIF (2)

PMID Text
22540025 CENP-C works as an important factor for centromeric M18BP1 recruitment
17199038 Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1]

AA Sequence

MIATPLKHSRIYLPPEASSQRRNLPMDAIFFDSIPSGTLTPVKDLVKYQNSSLKLNDHKKNQFLKMTTFN      1 - 70
NKNIFQSTMLTEATTSNSSLDISAIKPNKDGLKNKANYESPGKIFLRMKEKVLRDKQEQPSRNSSLLEPQ     71 - 140
KSGNNETFTPNRVEKKKLQHTYLCEEKENNKSFQSDDSSLRASVQGVPLESSNNDIFLPVKQKIQCQQEK    141 - 210
KAPLHNLTYELPTLNQEQENFLAVEARNKTLTRAQLAKQIFHSKESIVATTKSKKDTFVLESVDSADEQF    211 - 280
QNTNAETLSTNCIPIKNGSLLMVSDSERTTEGTSQQKVKEGNGKTVPGETGLPGSMKDTCKIVLATPRLH    281 - 350
ITIPRRSKRNISKLSPPRIFQTVTNGLKKNQVVQLQEWMIKSINNNTAICVEGKLIDVTNIYWHSNVIIE    351 - 420
RIEHNKLRTISGNVYILKGMIDQISMKEAGYPNYLIRKFMFGFPENWKEHIDNFLEQLRAGEKNREKTKQ    421 - 490
KQKTGRSVRDIRKSMKNDARENQTDTAQRATTTYDFDCDNLELKSNKHSESPGATELNMCHSNCQNKPTL    491 - 560
RFPDDQVNNTIQNGGGDDLSNQELIGKKEYKMSSKKLKIGERTNERIIKSQKQETTEELDVSIDILTSRE    561 - 630
QFFSDEERKYMAINQKKAYILVTPLKSRKVIEQRCMRYNLSAGTIKAVTDFVIPECQKKSPISKSMGTLE    631 - 700
NTFEGHKSKNKEDCDERDLLTVNRKIKISNLEKEQMLTSDFKKNTRLLPKLKKIENQVAMSFYKHQSSPD    701 - 770
LSSEESETEKEIKRKAEVKKTKAGNTKEAVVHLRKSTRNTSNIPVILEPETEESENEFYIKQKKARPSVK    771 - 840
ETLQKSGVRKEFPITEAVGSDKTNRHPLECLPGLIQDKEWNEKELQKLHCAFASLPKHKPGFWSEVAAAV    841 - 910
GSRSPEECQRKYMENPRGKGSQKHVTKKKPANSKGQNGKRGDADQKQTIKITAKVGTLKRKQQMREFLEQ    911 - 980
LPKDDHDDFFSTTPLQHQRILLPSFQDSEDDDDILPNMDKNPTTPSSVIFPLVKTPQCQHVSPGMLGSIN    981 - 1050
RNDCDKYVFRMQKYHKSNGGIVWGNIKKKLVETDFSTPTPRRKTPFNTDLGENSGIGKLFTNAVESLDEE   1051 - 1120
EKDYYFSNSDSA                                                             1121 - 1132
//

Text Mined References (19)

PMID Year Title
25755297 2015 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22540025 CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17339379 2007 Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.
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