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Tdark Protein Mis18-alpha

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

 Comments

Property Summary

NCBI Gene PubMed Count 16
PubMed Score 100.96
PubTator Score 22.53

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count
Down syndrome 548
Muscle Weakness 92
Disease Target Count Z-score Confidence
Suppurative periapical periodontitis 2 3.538 1.8
Hypoglycemia 81 3.283 1.6

Expression

  Differential Expression (17)

Disease log2 FC p
malignant mesothelioma 1.500 2.6e-06
glioblastoma 1.500 2.0e-05
osteosarcoma -1.111 1.2e-02
sonic hedgehog group medulloblastoma 2.400 3.6e-06
medulloblastoma, large-cell 1.600 1.9e-04
primitive neuroectodermal tumor 1.200 1.1e-03
adrenocortical carcinoma 1.082 7.1e-03
non-small cell lung cancer 1.528 3.8e-22
intraductal papillary-mucinous neoplasm ... 1.700 6.9e-04
lung cancer 1.900 3.6e-04
pediatric high grade glioma 1.400 1.2e-03
atypical teratoid/rhabdoid tumor 1.300 2.0e-04
aldosterone-producing adenoma -1.094 9.6e-03
lung adenocarcinoma 1.100 2.3e-08
nasopharyngeal carcinoma 1.200 1.3e-03
psoriasis 1.100 8.3e-12
ovarian cancer 1.400 3.6e-03

Synonym

Accession Q9NYP9 B2R562 Q542Z0
Symbols B28
FASP1
C21orf45
C21orf46
MIS18alpha
hMis18alpha

Gene

MIS18A

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

 UniProt Keyword (11)

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 GO Function (1)

 GO Component (5)

 GO Process (6)

 Compartment GO Term (28)

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 MGI Phenotype (3)

 HCA RNA Cell Line (56)

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Pathway (5)

Protein-protein Interaction (47)

CENPX   OIP5   NPM1   HIST2H4A   RBBP4   ITGB3BP   RBBP7   CENPW   CENPP   MIS18BP1   CENPU   CENPQ   CENPL   CENPS   HJURP   KNL1   CENPI   CENPT   CENPN   CENPK   CENPO   CENPH   CENPM   RUVBL1   PCNT   UACA   ACTR1A   ACTR1B   BICD2   HOMER1   DCTN3   TXLNG   DCTN2   CEP135   OFD1   SENP5   CCDC96   ACTR10   PCM1   TXLNA   DCTN5   DCTN6   DCTN4   OSBPL6   SYBU   BFSP1   CCDC170  

Gene RIF (3)

PMID Text
26942680 Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition.
17199038 Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1]
15881666 it is suggested that pp5644 physically bind to FASP1

AA Sequence 

MAGVRSLRCSRGCAGGCECGDKGKCSDSSLLGKRLSEDSSRHQLLQKWASMWSSMSEDASVADMERAQLE      1 - 70
EEAAAAEERPLVFLCSGCRRPLGDSLSWVASQEDTNCILLRCVSCNVSVDKEQKLSKREKENGCVLETLC     71 - 140
CAGCSLNLGYVYRCTPKNLDYKRDLFCLSVEAIESYVLGSSEKQIVSEDKELFNLESRVEIEKSLTQMED    141 - 210
VLKALQMKLWEAESKLSFATCKS                                                   211 - 233
//

Text Mined References (21)

PMID Year Title
26942680 2016 Licensing of Centromeric Chromatin Assembly through the Mis18?-Mis18? Heterotetramer.
26921242 2016 Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.
25416956 2014 A proteome-scale map of the human interactome network.
25036634 2014 Polo-like kinase 1 licenses CENP-A deposition at centromeres.
24270810 2013 High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21516116 2011 Next-generation sequencing to generate interactome datasets.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17199038 2007 Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15881666 2005 P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12036298 2002 Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.
11001876 2000 Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.
10830953 2000 The DNA sequence of human chromosome 21.
10773462 2000 Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21.