Tbio MIS18A Protein Mis18-alpha

Protein Summary

Description

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Uniprot Accession IDs

• Q9NYP9
• B2R562
• Q542Z0

Gene Name

• MIS18A

Ensembl ID

• ENST00000290130
• ENSP00000290130
• ENSG00000159055

Symbol

• C21orf45
• C21orf46
• FASP1
• B28
• FASP1
• C21orf45
• C21orf46
• MIS18alpha
• hMis18alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor perturbation	0.84
kinase perturbation	0.76
transcription factor binding site profile	0.66
tissue sample	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.84   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.84   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0