MIF4GD
MIF4G domain-containing protein
Protein Summary
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation. This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
- ENST00000245551
- ENSP00000245551
- ENSG00000125457
- ENST00000325102
- ENSP00000321625
- ENST00000577542
- ENSP00000463334
- ENST00000579297
- ENSP00000462459
- ENST00000618645
- ENSP00000484245
- SLIP1
- MIFD
- AD023
- SLIP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.82 | ||
transcription factor perturbation | 0.74 | ||
transcription factor binding site profile | 0.71 | ||
tissue sample | 0.64 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.5 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.5 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0